Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"polarity proteins"”.
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Quantitative super-resolution imaging of cell polarity proteins using DNA-PAINT
… the localisation and spatial organisation of proteins is crucial for understanding their function. The development of super-resolution imaging has improved our ability to garner this information, but counting individual molecules in densely-packed assemblies is still challenging. DNA-based …
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Hexagonal packing of Drosophila wing epithelial cells by the Planar Cell Polarity pathway
… depends on the activity of the Planar Cell Polarity proteins. The Planar Cell Polarity group of proteins coordinates complex and polarized cell behavior in many contexts. No common cell biological mechanism has yet been identified to explain their functions in different tissues. A genetic …
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Mechanisms of Gradient Tracking During Yeast Mating
… partners. Exposure to pheromone causes polarity regulators to cluster into a tight "patch" at the cortex, directing growth toward that site. Timelapse microscopy of fluorescently-labeled polarity proteins revealed that the patch wandered around the cortex during gradient tracking. …
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Cell Polarity Establishment in the Budding Yeast Saccharomyces Cerevisiae
<p>Establishing an axis of cell polarity is central to cell motility, tissue morphogenesis, and cell proliferation. A highly conserved group of polarity regulators is responsible for organizing a wide variety of polarized morphologies. One of the most widely expressed polarity regulators is the …
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The Effects of Acetylenic Tricyclic Bis-(Cyano Enone) on Cell Migration
… disrupted by TBE-31, and the localization of the polarity proteins Rac1, IQGAP and Tiam1 were altered from the leading edge of migrating cells. Lastly, TBE-31 was shown to inhibit Rat2 and NIH3T3 fibroblast as well as H1299 non-small cell lung cancer tumour cell migration. Taken together, my work …
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Establishing and Maintaining Cortical Asymmetry in <i>Drosophila</i> Neural Stem Cells
… fluorescent reporters for apical and basal polarity proteins and imaged their localisation live. We reveal that localisation appears to happen in two stages. Firstly, Miranda is localised uniformly to the plasma membrane, from where it is cleared by aPKC at the onset of prophase in an actin …
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Dynamics of Cell Packing and Polar Order in Developing Epithelia
… a signaling system is the network of interacting proteins that control planar polarization of cells. These proteins distribute asymmetrically within cells and their distribution in each cell determines of the polarity of the neighboring cells. These proteins control the pattern of hairs in the …
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big bang, a novel regulator of tissue growth in Drosophila melanogaster
… link tissue growth/Hippo signaling with cell polarity and the actin cytoskeletal organization. The aim of this thesis was the study of the interplay between cell polarity, cytoskeletal organization and tissue growth. To gain further insight into how apical polarity proteins regulate tissue …
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Polarity establishment and signalling mechanisms controlling patterning in Hibiscus Trionum petals
… of the petal, but the establishment of tissue polarity is also not well understood. Through my PhD work I have started to address both aspects by characterising polarity establishment during petal development and by investigating one possible signalling mechanism controlling cell …
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Regulation of Cell Adhesion By The Ferm Proteins, Ptpn14 and Merlin
… tissue organization and homeostasis. A family of proteins that regulate cell-cell adhesions is the FERM (<strong>4</strong>.1 protein, <strong>E</strong>zrin, <strong>R</strong>adixin, <strong>M</strong>oesin) domain-containing proteins.One FERM domain protein, the non-receptor tyrosine …
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Experimentally informed bottom-up model of yeast polarity suggests how single cells respond to chemical gradients
… of each cell—defined by a patch of cortical polarity proteins—undergoes a series of erratic and random movements along the cell cortex till it ‘finds’ the mating partner’s patch. We sought to understand how polarity patches in misaligned cells find each other. To this end, we first …
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Merlin Mediated Regulation of Hair Follicle Morphogenesis
… junctions (AJ). The AJ is composed of the core proteins E-cadherin, β-catenin and α-catenin. α-catenin acts to tether the AJ complex to the actin cytoskeleton. In addition to the core AJ proteins, proper formation and maturation of the AJ is dependent upon a multi-protein complex called the …