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Showing 1 to 5 of 5 for “"pol protein"”.
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Untersuchungen zum Gag- und Pol-Protein des Prototypischen Foamyvirus (PFV)
… sich die Foamyviren (FV) bezüglich ihrer Proteinexpression, der Partikelmorphogenese und ihres Reproduktionszyklus deutlich von den Orthoretroviren. Im Rahmen dieser Arbeit wurden zwei exklusive Merkmale der Foamyviren, die ungewöhnliche Struktur des Gag-Proteins und die Gag unabhängige …
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Characterization of Human T-Cell Leukemia Virus 1 Reverse Transcriptase
… from human cell lines. Because large amounts of protein could not be produced by this isolation method, the reverse transcriptase cannot be fully characterized. In this research, a recombinant protein expressed in <em>E. coli</em> was purified, which has an apparent molecular weight consistent …
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Mechanismus der Polymerase-Inkorporation in foamyvirale Partikel
… mit Ausnahme der Foamyviren (FV), wird das Pol-Protein als Gag-Pol-Fusionsprotein exprimiert. Dieser Mechanismus sichert die Inkorporation von Pol in das virale Partikel. FV unterscheiden sich in vielen Merkmalen von den Orthoretroviren, unter anderem wird das Pol-Protein von einer eigenen …
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Foamy Virus Enzymes - Activity, Regulation and Resistance
… Viral particles contain DNA not RNA. The Pol protein, the precursor of the viral enzymes, is translated from a separate mRNA independently of the capsid and matrix proteins. The protease remains covalently bound to the reverse transcriptase, while in orthoretroviruses the protease is …
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Drug Resistance Mutations in Naive HIV-1 South African Patients, and Construction of Molecular Clones to Phenotype Putative Resistance Mutations
… p24 production was obtained from all four gap-pol plasmids. MJ4/NL4-3 worked better in delivering luciferase to the target cells while NL4-3/ML4 appeared totally devoid of any infectivity. The vectors pCMVGagPol(MJ4)-RREr and pCMVGagPol(NL4.3)-RREr were created and both expressed the viral …