Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"pneumococcus"”.
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Studies on the Teichoic Acids of the Pneumococcus
<p>The investigations described in this dissertation are presented in two parts. Part I deals with the mode of segregation of the pneumococcal wall teichoic acid during cell growth and division. Teichoic acid was labeled with <sup> 3</sup>H-choline (a teichoic acid-specific constituent of …
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Properties of the Merozygotes Associated with a Sulfonamide-Resistant Mutation in Pneumococcus
… applied to a sulfanilamideresistant mutant of pneumococcus which regularly segregates to strains sensitive to sulfanilamide and resistant to p-nitrobenzoic acid, another analogue of paraminobenzoic acid. From a combination of information gathered by previous workers and new data, it is …
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Pathogen evolution within and between hosts with applications to the pneumococcus and SARS-CoV-2
The tracking of a pathogen's evolution over different timescales is essential: for the design of vaccines, to control antibiotic resistance, for the surveillance of disease, to identify transmission chains and to understand the mechanisms behind the pathogen’s evolution. Although the first …
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The Pneumococcus Urinary Antigen Test Kit: Use in the laboratory for the presumptive diagnosis of pneumococcal bacteraemia
Introduction: Culture remains the ‘gold standard' for diagnosis of Streptococcus pneumoniae bacteraemia. Time to definitive identification using culture is 24–48 hours, and prior antibiotic therapy, the ability of S. pneumoniae to self-autolyse and its fastidious nature can yield no growth on …
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Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study
Streptococcus pneumoniae (the pneumococcus) is the most common cause of childhood pneumonia. Nasopharyngeal (NP) colonization by the pneumococcus is a necessary first step in the pathogenesis of pneumonia and yet the dynamic nature of pneumococcal colonization remains incompletely understood. In …
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Studies on pneumococci isolated from children in the Sheffield area.
The isolation of the pneumococcus (Streptococcus pneumoniae) was improved, and gave large mucoid colonies, when incubated in an anaerobic environment containing extra CO2. Both reduction of oxygen tension, with a reduction in the formation of peroxides, and a variable requirement for CO2 were …
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The Role of Streptococcus Pneumoniae Carriage on Wasting Among Vaccinated Gambian Infants: A Longitudinal Analysis of a Birth Cohort
… agents such as Streptococcus Pneumoniae (pneumococcus) may have negative impacts on child growth and nutritional status. The aim this study is to investigate the determinants of wasting and to assess the effect of pneumococcus carriage on wasting in children under the age of 2 years. The …
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Investigating galactose metabolism in Streptococcus pneumoniae
… for between 1 and 2 million deaths annually, the pneumococcus makes a major contribution to global morbidity and mortality. In order to cause disease, the pneumococcus must first colonise the human nasopharynx. This colonisation is typically asymptomatic and provides the ideal niche from which the …
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Genomic diversity in naturally transformable Streptococcus pneumoniae
Infections due to Streptococcus pneumoniae (the pneumococcus) remain a substantial source of morbidity and mortality in both developing and developed countries despite a century of research and the development of effective therapeutic interventions (such as antibiotic therapy and vaccination). The …
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Geographic Migration and Evolution of Streptococcus pneumoniae
Streptococcus pneumoniae (the pneumococcus) is a human-obligate, opportunistic bacteria. It resides asymptomatically in the nasopharynx of both children and adults. It occasionally goes on to cause local disease such as otitis media, or severe invasive disease as with pneumonia and meningitis. It …
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Investigation of the role of a large serine rich repeat protein in Streptococcus pneumoniae
… resistance and vaccine escape is increasing. The pneumococcus causes a wide range of diseases, and this can be attributed to both the succeptibility of the human host and the genetic background of the infecting strain. The study of the contribution of variations in the genome of S.pneumoniae is …
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Interactions between influenza A virus and Streptococcus pneumoniae in nasal colonization and middle ear infection
Streptococcus pneumoniae (pneumococcus) is a tremendously variable pathogen. Reflecting this, it is both a nearly ubiquitous nasopharyngeal colonizer and also a leading cause of otitis media, one of the most common diseases of childhood. Despite this, the factors underlying its transition from …
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The contribution of competence system to the virulence of Streptococcus pneumoniae
Competence induction in Streptococcus pneumoniae (pneumococcus) is initiated by the binding of the 17-amino acid competence stimulating peptide (CSP) to its membrane-associated histidine sensor kinase ComD. ComD autophosphorylates and subsequently phosphorylates and activates its cognate response …
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Activation State of Human T and NK Cells Increases Sensitivity to Death by Streptococcus pneumoniae
… significantly increase sensitivity to death by pneumococcus depending on lymphocyte subset.
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Amino acid utilization by Aerobacter aerogenes and Escherichia coli
… but he was interested in pathogenic organisms (Pneumococcus, Streptococuss hemolyticus and diphtheria Bacillus) more than in the two species we are studying and, furthermore, we do not approve completely of the methods of inoculation and of growth measurement he used. (See under these headings …
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A pan-genome wide association study to identify genes associated with invasive Streptococcus pneumoniae
Streptococcus pneumoniae (pneumococcus) is one of the leading causes of mortality in Africa. It asymptomatically colonizes the human nasopharynx. The invasive pneumococcal disease occurs when isolates spread to normally sterile sites such as lungs, blood, and the central nervous system. …
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Immunomodulatory effect of pneumolysin upon CD4 T cells
… pathogen, Streptococcus pneumoniae (the pneumococcus), has been shown to modulate different parts of the innate immune response of its host, however its ability to modulate the adaptive immune response remains largely uninvestigated. Furthermore, the importance of the adaptive arm of the …
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Effect of anti-microbial immunizations in the progression of amyloid and neuroinflammatory pathologies in a mouse model of Alzheimer's disease
… with controls and mice immunized against pneumococcus. These findings support clinical evidence suggesting that anti-microbial vaccinations protect the brain from neurodegenerative insults. Importantly, this thesis demonstrates the neuroprotective effects of vaccinations against …
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Modelling longitudinal data on respiratory infections to inform health policy
… quantify the interaction between influenza and pneumococcus. Counterfactual analysis can also be employed to quantify the burden of novel respiratory pathogens. The last application of this approach is to estimate the excess mortality during the the COVID-19 pandemic in England.
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Nasopharyngeal colonization dynamics with Streptococcus pneumoniae and associated antimicrobial resistance in a South African birth cohort
… colonization by Streptococcus pneumoniae (the pneumococcus) precedes the development of respiratory tract infection. Colonization by antimicrobial-resistant pneumococci, especially in infants, is a major public health concern as pneumococcus is a frequent cause of bacterial acute respiratory …
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