Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"pneumococcal conjugate vaccine"”.
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Aetiology and presentation of childhood pleural infections in the post-pneumococcal conjugate vaccine era in South Africa
Complications of respiratory infections include pleural effusion (PE), associated with a high morbidity. Differentiating between PE caused by bacterial infections and Mycobacterium tuberculosis (TB) in endemic areas is difficult in children, impacting treatment. We investigated the aetiology of PE …
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Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study
… of pneumonia and yet the dynamic nature of pneumococcal colonization remains incompletely understood. In children, asymptomatic colonization of the nasopharynx by the pneumococcus is common and also serves as a reservoir for person-to-person transmission. We aimed to investigate in detail, …
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Evaluation of a Multiplex Real-Time PCR Assay to Simultaneously Detect Streptococcus pneumoniae and Staphylococcus aureus in Nasal Samples
… with nasal carriage of these bacteria. Use of a pneumococcal conjugate vaccine (PCV) in children altered nasal carriage rates and reduced infections due to <em>S. pneumonia. </em>Similar studies demonstrate that there is an inverse correlation between <em>S. pneumoniae</em> and <em>S. aureus</em> …
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MULTIPLEX REAL TIME PCR and MELT CURVE ASSAY DEVELOPMENT FOR THE SIMULTANEOUS DETECTION AND IDENTIFICATION OF STREPTOCOCCUS PNEUMONIAE and STAPHYLOCOCCUS AUREUS
… may be altered in individuals immunized with the pneumococcal conjugate vaccine, raising concerns that vaccinated individuals may be more likely to carry MRSA. Assessing the carriage rate of these bacteria in both vaccinated and non-vaccinated individuals may provide important information to …
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Reducing the Burden of Bacterial Meningitis in the African Meningitis Belt After MenAfriVac
… MenAfriVac, a serogroup A meningococcal conjugate vaccine, was introduced in mass campaigns in 2010 and has significantly reduced carriage and incidence of group A disease across the meningitis belt. However, other meningococcal serogroups and Streptococcus pneumoniae continue to cause …
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Acute Mastoiditis in Children – A National Study in Sweden
… guidelines, in the year 2009, immunisation with pneumococcal conjugate vaccine (PCV) against the most invasive serotypes of Streptococcus pneumoniae, the most common bacteria causing AOM as well as AM, was introduced into the standard immunisation schedule in Sweden. The national study …
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DRY POWDER INHALATION OF PNEUMOCOCCAL VACCINE USING POLYMERIC NANOPARTICLES AS CARRIERS
… pneumoniae is the leading bacterial cause of pneumococcal diseases, of which pneumonia is the main cause of death amongst the immunocompromised, elderly over the age of 50 and children under the age of 5. Although vaccines such as pneumococcal polysaccharide vaccine 23, pneumococcal conjugate …
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Novel strategies to prevent and treat experimental pneumococcal disease
… unevenly distributed around the world, current vaccine formulations vary significantly in their ability to protect against invasive pneumococcal disease (IPD). The adult pneumococcal vaccine is composed of capsular polysaccharide from 23 of the most prevalent disease causing serotypes. Purely …
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An investigation towards a conjugate vaccine against Streptococcus pneumoniae serotype 19A
… is a human pathogen that causes invasive pneumococcal diseases (IPD) such as pneumonia, otitis media and sepsis particularly in children, the elderly, and patients with HIV, and other immunosuppressive conditions. Conjugate vaccines comprised of the bacterial surface polysaccharide …
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Geographic Migration and Evolution of Streptococcus pneumoniae
… in any given location. Highly immunogenic conjugate vaccines have been implemented in >76% of national immunization schedules; we also have many antimicrobials to which the pneumococcus is susceptible. Following the introduction of the pneumococcal conjugate vaccine in the 2000’s there have …
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Nasopharyngeal colonization dynamics with Streptococcus pneumoniae and associated antimicrobial resistance in a South African birth cohort
… African infants immunized with the 13- valent pneumococcal conjugate vaccine (PCV13). Furthermore, the study explored strainlevel pneumococcal colonization patterns and associated antimicrobial resistance determinants as well as the composition of the NP antibiotic resistome using shotgun …
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Descriptive analysis of routine childhood immunisation timelines in the Western Cape, South Africa
… immunisation schedules is critical in ensuring vaccine effectiveness against vaccine preventable diseases (VPDs). Delays in the uptake of routine childhood immunisations lead to an increase in children susceptible to VPDs. Catch-up vaccination campaigns are strategies aimed at minimising the …