Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"pleural mesothelioma"”.
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Stromal interactions in pleural mesothelioma
Pleural mesothelioma (PM) is a devastating malignancy primarily related to past asbestos exposure. There are no curative options, and 1-year survival stands currently at just 40%. The genomic landscape in mesothelioma is dominated by loss of function of tumour suppressor genes rather than …
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Zirconium-based Metal-Organic Frameworks for Pleural Mesothelioma Therapy
… studies to improve the treatment of malignant pleural mesothelioma, an incurable cancer with a survival time of only one year after diagnosis. Mesothelioma is mainly caused by exposure to mining asbestos, a natural fibre widely used in building constructions. This untreatable cancer is …
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The significance of the EGFR pathway in malignant pleural mesothelioma
… MTOR and COX2 are up regulated in malignant pleural mesothelioma (MPM). In this study we aimed to determine the expression of Lipoxygenase enzymes (LOX), absence of PTEN protein expression and the cytotoxic effect of EGFR, MTOR and COX2 inhibitors in MPM.Materials and …
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Cullin 4B Ubiquitin Ligase Is Important for Cell Survival and Regulates TGF-β1 Expression in Pleural Mesothelioma
… was associated with worse outcomes of pleural mesothelioma (PM) patients, while the overexpression of its paralog CUL4A was not associated with clinical outcomes. Here, the work aimed to identify the distinct roles of CUL4B and CUL4A in PM using an siRNA approach in PM cell lines (ACC …
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The added value of BAP1 immunohistochemistry and fluorescence in situ hybridisation for CDKN2A/p16 and NF2 in the diagnosis and prognostication of pleural mesothelioma
Background: Mesothelioma is a rare but aggressive malignancy with therapeutic options that are generally palliative. The malignancy can be challenging to diagnose, commonly due to scant samples, often requiring patients to undergo multiple procedures before a definitive diagnosis can be reached. In …
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To evaluate the role of miRNAs as potential diagnostic and prognostic biomarkers for Asbestos-related interstitial lung diseases (ILD), Non-Small Cell Lung Cancer (NSCLC) and Malignant Pleural Mesothelioma (MPM)
… Asbestos-related lung cancer (LC) and malignant pleural mesothelioma (MPM) prognosis is still poor especially at advanced stage, which highlights the need for early diagnosis and effective biomarkers capable of detecting these diseases at early, potentially reversible stages. MicroRNAs have been …
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CHARACTERIZATION OF IMMUNE RESPONSE IN EXPERIMENTAL MOUSE MODELS
… interaction in a murine model of orthotopic pleural mesothelioma.
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Prognostic models for mesothelioma : variable selection and machine learning
Malignant pleural mesothelioma is a rare and lethal form of cancer affecting the external lining of the lungs. Extrapleural pneumonectomy (EPP), which involves the removal of the affected lung, is one of the few treatments that has been shown to have some effectiveness in treatment of the disease …
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The experience of mesothelioma in Northern England
Mesothelioma is a potentially preventable fatal disease causing almost 2000 deaths/year in the UK, increasing in incidence, and lacking effective treatments. ‘The Experience of Mesothelioma in Northern England’ is a community-based, mixed methods, case study in four parts, conducted in …
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Rational drug combinations to selectively target 9p21-deleted bladder cancer
… combinations in pancreatic adenocarcinoma and pleural mesothelioma cells with 9p21 loss, suggesting that other tumor types may benefit from these treatments. We recognize that while this study is limited by the lack of validation in more complex cancer models the implications of drugs with …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
<p>The highly aggressive cancer, malignant mesothelioma, responds poorly to available treatment options. As most individuals diagnosed with these tumors succumb to the disease within about 2 years of diagnosis, it is imperative to develop a more thorough understanding of molecular mechanisms of the …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
<p>The highly aggressive cancer, malignant mesothelioma, responds poorly to available treatment options. As most individuals diagnosed with these tumors succumb to the disease within about 2 years of diagnosis, it is imperative to develop a more thorough understanding of molecular mechanisms of the …
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Determination of p53 role in cancer biology and therapy through interactome development and analysis
… 61 deregulated genes considered as important to mesothelioma (Meso-PMH61 model), and superimposed microarray data generated in our laboratory of mesothelioma cells treated with etoposide and 1 % O2 oxygen.We analysed all models, in silico, using CellNetAnalyzer. In silico knockout analysis of …