Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"plectin"”.
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Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3
… FET proteins were found to bind the cytolinker plectin and FUS was shown to form complexes with plectin in the cell cytoplasm. Plectin expression was required for normal FUS function as plectin knockout cells revealed a shift in FUS nucleo-cytoplasmic distribution and a deregulation of FUS …
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Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.
… of the LINC complex (Sun-1, nesprin-2/3) and Plectin. Plectin links components of the nuclear envelope (nesprin-3) with cytoskeleton and ChIP-qPCR assay with adult epidermal keratinocytes showed p63 binding to the consensus binding sequences on Plectin 1c, Sun-1 and Nesprin-3 promoters. As a …
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Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma
… The resulting nanopolyplex is modified with a plectin-1-targeting peptide to enhance the accumulation of the nanopolyplex in pancreatic tumors. The nanopolyplex aims to normalize the stroma by blocking the interaction between tumor cells and pancreatic stellate cells to inhibit the activation …
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Targeting extracellular matrix using siRNA for the treatment of liver fibrosis and pancreatic cancer
… nanocomplexes was further condensed with plectin-1-G-pE6-M-PD-L1 (PGEMP) polypeptide. We assessed the characteristics of the resulting nanocomplexes, including particle size, cell viability, silencing activity, and serum stability. This strategy provides a promising platform for improving …