Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"platinum resistance"”.
-
TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
Adaptive chemoresistance remains a critical barrier to effective ovarian cancer therapy, necessitating a deeper understanding of the cellular and metabolic changes that drive platinum resistance. Here, we dissect the interplay between platinum-induced genotoxic stress, type-I protein arginine …
-
Clinical resistance to platinum chemotherapy in ovarian cancer
Platinum drugs are the most active agents in ovarian cancer. Their cytotoxicty results from DNA crosslinking. High tumour response rates are seen, but 80 % of patients relapse. Major mechanisms of platinum resistance in patients remain to be established. We have studied DNA interstrand crosslinking …
-
Tumour evolution in ovarian cancer using high-throughput genomics technologies
… at diagnosis and the frequent emergence of platinum resistance. This thesis explores the use of high-throughput genomics technologies to understand if resistance could be explained by the model of tumour evolution. We performed SNP array analysis of a cell line model system of platinum …
-
Thermal transport in individual single-wall carbon nanotubes
… of two adjacent suspended membranes, each with a platinum resistance heater and thermometer, was used to directly measure the thermal conductance of three individual SWCNTs. These results show the effects of Umklapp phonon-phonon scattering remain weak and the thermal conductance remains roughly …
-
INVESTIGATING EPIGENETIC MECHANISMS OF CHEMORESISTANCE IN OVARIAN CANCER: THE ROLE OF H3K27ME3
… and associated with an increased tumour resistance to chemotherapy, compared to Long-Term Survivors (LTS) (> 10 years after diagnosis), with an improved sensitivity to the platinum-based treatment. By epi-proteomic profiling, we also confirmed a similar loss of this histone mark in an …
-
Application of thin film PRTD's for the monitoring of cutting tool temperature during turning
… to investigate the applicability of a thin film Platinum Resistance Temperature Detector (PRTD) sensor in the monitoring of cutting tool temperature for a turning tool. The thin film PRTD offers a small size, industrially durable method of monitoring cutting tool temperature with a quick response …
-
DEVELOPMENT OF A MICROSCALE ELECTROCHEMICAL PLATFORM FOR THE ANALYSIS OF THERMAL PROFILES OF IMMOBILIZED DNA SECONDARY STRUCTURES
… planar electrochemical platform with an embedded platinum thin film that can function as both a platinum resistance thermometer (PRT) and as a resistive microheater. The device assembly as well as automation of the temperature control and electrochemical methods have been instituted to increase …
-
Investigating the Existence of Coherent Phonon Scattering in Silicon Using Phononic Crystals
… a silicon nitride suspended island platform with platinum resistance temperature detectors and coated with aluminum nitride. A silicon slab was concurrently measured with each PnC, and relative thermal conductivity values were determined. The addition of the PnC decreased Si's thermal conductivity …
-
Quantitative impurities effects on temperatures of tin and aluminium fixed-point cells
… temperature fixed points. It also uses long-stemplatinum resistance thermometers to interpolate between the fixed points from 660 °Cdown to 84 K (if one includes the Argon triple point). Impurities are a major source of uncertainty in the fixed point temperature (of the order of 1 mK). And a …
-
Phonon scattering from monovalent substitutional impurities in sodium chloride
… in a liquid helium cryostat using germanium resistance thermometer~ which had Peen previously calibrated against a gas thermometer and a vapol;' pressure thermometer. The range 65°K to 300 0K was covered in a liquid nitrogen cryostat using platinum resistance thermometers prev.iously …
-
Tracking Treatment Response and Resistance to Parp Inhibition (Talazoparib) In Hereditary Pancreatic Cancer.
… PDAC patients respond to PARP inhibitors, and resistance has been observed.</p> <p>In order to explore resistance to PARP inhibitors in PDAC and I hypothesized that: 1. Genomic alterations are responsible for response and resistance to PARP inhibitor (Talazoparib) treatment in pancreatic …
-
Circumventing Cisplatin Resistance In Ovarian Cancers Through Reactivation of P53 By Non-Cross-Resistant Platinum Analogs
… <p><strong>CIRCUMVENTING CISPLATIN RESISTANCE IN OVARIAN CANCERS THROUGH REACTIVATION OF P53 BY NON-CROSS-RESISTANT PLATINUM ANALOGS</strong></p> <p><strong>Michelle Martinez-Rivera, B.S.</strong></p> <p><strong>Advisory Professor: Zahid H. Siddik, Ph.D.</strong></p> <p>Cisplatin …
-
Dynamic pressure sensors for hypersonic flow measurements
This Ph.D. dissertation will focus on the research and development of an acoustic pressure sensor tailored for hypersonic boundary layer flow measurements. Hypersonic boundary layer flows comprise shocks, laminar-to-turbulent transitions, and high-frequency turbulence with small (sub 1-mm) …