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Showing 1 to 13 of 13 for “"platinum drugs"”.
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Mechanisms of Accumulation and Biological Consequences of Polynuclear Platinum Compounds
… and cellular uptake than clinical anticancer platinum drugs such as cisplatin, oxaliplatin and carboplatin. The clinical efficacy of cisplatin, oxaliplatin and carboplatin is limited due to acquired resistance and dose limiting side effects. The three major pharmacological factors contributing …
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Pyrazole and pyrazolyl palladium(II) and platinum(II) complexes: synthesis and in vitro evaluation as anticancer agents
The use of metallo-pharmaceuticals, such as the platinum drugs, for cancer treatment illustrates the utility of metal complexes as therapeutic agents. Platinum group metal complexes therefore offer potential as anti-tumour agents to fight cancer. This study was aimed at synthesizing and evaluating …
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The Expression of Copper Transporters in Rat Dorsal Root Ganglion Neurons and its role in Oxaliplatin Neurotoxicity
Oxaliplatin is a platinum-based anticancer agent used for the treatment of colorectal cancer. Oxaliplatin chemotherapy is associated with peripheral neuropathy and dorsal root ganglia neurons are the putative target, however the mechanism of toxicity is currently unknown. Recent evidence suggests …
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Drug Design, Biological Activity, and Metabolic Consequences of Cytotoxic Platinum Compounds: Utilizing Fluorescent Tagging to Understand Drug Action and Metabolism
Platinum drugs are among the most commonly used chemotherapeutics for the treatment of testicular, head and neck, ovarian, small cell lung, and colorectal carcinomas. Although the current set of platinum chemotherapeutics has proven somewhat successful, the overall success of platinum based drugs …
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HPLC analysis to assess efficacy of cisplatin, nedaplatin, and oxaliplatin
Platinum drugs are one of the most widely used agents against cancerous cells. Cisplatin’s chemotherapeutic efficacy is limited by the increase of tumor resistivity and unwanted side effects. Cisplatin’s cytotoxicity is linked to its ability of forming 1,2-intrastrand adducts with adjacent guanine …
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CHARACTERIZATION OF THE RNA BINDING MODE OF A PLATINUM-ACRIDINE AGENT
… of solid tumor cell lines. Unlike the classical platinum-based cross-linking drugs, this agent produces its cytotoxic effect by two synergistic DNA binding mechanisms: monofunctional platination and intercalation of the acridine chromophore. The RNA binding of platinum drugs has been studied to a …
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Developments in the chemistry and nanodelivery of platinum anticancer agents
… receiving cancer chemotherapy are treated with a platinum-containing drug. Despite this intense clinical use, only three platinum complexes, cisplatin, carboplatin, and oxaliplatin, are approved by the United States Food and Drug Administration for the treatment of cancer. A number of side effects …
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Clinical resistance to platinum chemotherapy in ovarian cancer
Platinum drugs are the most active agents in ovarian cancer. Their cytotoxicty results from DNA crosslinking. High tumour response rates are seen, but 80 % of patients relapse. Major mechanisms of platinum resistance in patients remain to be established. We have studied DNA interstrand crosslinking …
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Platinum-NGR A Peptide Targeting Conjugate Of Cisplatin: Design, Synthesis, And Efficacy In Breast Cancer Cells
… leading causes of mortality in women worldwide. Platinum based chemotherapeutic drugs, such as cisplatin and carboplatin, are one of the primary therapies employed in the treatment of breast cancer. Adverse side effects caused by untargeted drug delivery of these platinum drugs are often a cause …
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Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
… commonly used chemotherapeutic agents, including platinum drugs, taxanes, epothilones and vinca alkaloids, but also newer agents such as bortezomib. Bortezomib (VELCADE) is a boronic acid dipeptide, which causes a selective blockade of proteasome activity. Bortezomib-induced peripheral neuropathy …
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Inorganic nanoparticles for applications in biomedical sciences
… advantages like delivery of poorly soluble drugs, better bioavailability, targeted delivery and extended release of drugs. In this work, we demonstrated the formulation and methods of use for three different nanocarriers. 1) 166Ho iron garnet nanoparticle-containing bandages for treatment of …
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Design, synthesis and biological evaluation of bioorganometallic metallarectangles
… treatment has largely depended on platinum-based drugs (e.g. cisplatin and its derivatives). Unfortunately, the use of these metallodrugs are accompanied by severe adverse side-effects. Additionally, the evolution of resistant cancer cell sub-types has rendered many of these highly …