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Showing 1 to 20 of 47 for “"platinum complexes"”.
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Palladium and platinum complexes of vitamin Bâ
Palladium and platinum complexes of pyridoxamine, pyridoxine and pyridoxal have been prepared. The structures of the complexes PtCI2PM.H20, trans-PdC12 (PN)2 and [PLH+ ]2[PtC16] 2- ,H20 have been determined by use of single crystal x-ray studies. The compounds PdC12PH, trans-PdC12 (PN) 2 , …
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Palladium and platinum complexes of substituted 4-vinylcyclohexene
<p>In recent years numerous complexes have been reported in which olefins were chelated to transition metals.Ever since the generally regarded first olefin complex, Zeise's salt (32) KPt(C<sub>2</sub>H<sub>4</sub)Cl<sub>3</sub>, the interest in this field of organometallic chemistry has expanded to …
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Palladium and platinum complexes of trans-coordinating bidentate phosphine ligands
… (PP), have been used in the preparation of complexes described in this work. Construction of molecular models proved useful in predicting the likely geometries of the complexes. For example, the ligand PP is capable of chelating trans- but not cis- in a mononuclear fourcoordinate …
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An investigation into the alkene hydroformylation reaction using platinum complexes
… both the bulk and specialty chemical industry. Platinum catalysts have shown significant chemo- and regioselectivities in alkene hydroformylation. This thesis investigates the activity as well as selectivity of platinum complexes containing bidentate ligands in the hydroformylation reaction.
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New methodologies for studying the biological activity of platinum complexes
A review of existing approaches to platinum drug discovery highlighted the need for new methods to perform mechanism-based, high-throughput screening of platinum complexes. A new solution phase screening method was based on the importance of high mobility group (HMG) domain proteins in the …
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Platinum Complexes and Zinc Finger Proteins: From Target Recognition to Fixation
… two other chemotherapeutic drugs containing platinum, carboplatin and oxaliplatin, have been used in the clinic. These three compounds are all bifunctional with the ligands surrounding platinum In the cis conformation and rearrangement of the ligands to the trans orientation results in a loss …
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Highly Luminescent Platinum Complexes for Light Emitting Devices and Bio-Imaging
Intensely luminescent cyclometallated platinum(II) complexes have been prepared containing N^C^N-coordinating ligands, based on 1,3-dipyridylbenzene. Exceptionally high quantum yields ( 0.85, degassed DCM, 298 K) are rationalised in terms of the particularly short Pt-C bond, which raises the energy …
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Platinum Complexes With Tridentate Ligands as Models for Active Monofunctional Anticancer Drugs
<p>Pt(II) complexes bind preferentially at N7 of G residues of DNA, causing DNA structural distortions associated with anticancer activity. Some distortions induced by difunctional cisplatin are also found for monofunctional Pt(II) complexes with carrier ligands having bulk projecting toward the …
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Hydroformylation of olefins by water soluble and asymmetric cobalt and platinum complexes
… phosphine modified water soluble cobalt and platinum complexes as homogeneous and immobilized hydroformylation catalysts. The ligands include (1) Monodentate phosphines: P[ (CH₂ ) <sub>n</sub>-C₆H₄-S0₃Na] ₃ (n = 0-3) and P[C₆H₄-NMe₃⁺BF₄⁻]₃; (2) Bidentate asymmetric phosphines: …
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High Pressure Liquid Chromatography Studies of the Reaction of Platinum Complexes with Peptides
Platinum complexes (cisplatin, carboplatin and oxaliplatin) are effective anticancer agents. However the major drawbacks of platinum chemotherapy are toxic side effects and resistance. The affinity of platinum complexes to sulfur donor ligands of side chains of methionine and cysteine amino acids …
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Synthesis, characterization and potential chromatographic separation of palladium and platinum complexes of N,N-Dialkyl-N'-Benzoylthioureas
… as well as their corresponding neutral bis complexes of type cis [ML₂] where M = Pd(II) and Pt(II) have been prepared and characterized. The structures of these compounds has been studied using high resolution nuclear magnetic resonance technique. Studies were also carried out to investigate …
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Peptide Targeting of Platinum Anti-Cancer Drug and Synthesis of Water Soluble Monofunctional Pt(II) Complexes Useful for Biological Labeling
Platinum has been used as an inorganic medicinal agent with various applications such as anti cancer agents. Several new targeted Pt(II) conjugates were synthesized having the NGR and LHRH targeting motif. The platinum conjugates bearing the NGR motif revealed selective delivery and destruction of …
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Synthesis and mechanistic studies of novel antitumor transition metal complexes
… Pt(II) drugs, our lab has developed novel platinum complexes. One of the new platinum complexes developed in our lab is the monofunctional platinum anti-cancer compound phenanthriplatin. We have found that by binding to sulfur complexes, phenanthriplatin undergoes changes in its kinetic and …
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Steric aspects of the interaction of metal species with nucleic acid constituents
… a focus has been placed on the interaction of platinum complexes with nucleoconstituents. Steric effects thus characterised have been related to the biological properties of such complexes. Steric aspects of metal complex speciation have been investigated both from experimental and theoretical …
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Synthesis, Characterization And Application Of Pt Complexes With Pincer Ccc-Bis(Nhc) Ligands
… pincer ligand supported transition metal complexes was extended to Pt. Several platinum complexes were synthesized. The identity of these complexes was confirmed through multiple technologies, including nuclear magnetic resonance spectroscopy, mass spectroscopy, elemental analysis, thermal …
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Developments in the chemistry and nanodelivery of platinum anticancer agents
… receiving cancer chemotherapy are treated with a platinum-containing drug. Despite this intense clinical use, only three platinum complexes, cisplatin, carboplatin, and oxaliplatin, are approved by the United States Food and Drug Administration for the treatment of cancer. A number of side effects …
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Design, Syntheses and Functional Studies of DNA Binding Metal Complexes
… anticancer activity. The interactions of these platinum complexes with the DNA-heptamer d(CCTGTCC):d(GGACAGG) were examined and a NMR based high resolution structure was determined. Surprisingly both platinum-DNA complexes do not form a very stable complex with its complementary strand. Over …
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The Reaction of a Water Soluble Platinum Compound with Methionine and Derivatives
Water soluble platinum complexes are a recent area of emphasis of cisplatin chemistry. The water soluble complexes could have a reduced toxicity compared with cisplatin. Oxaliplatin, which has an oxalate leaving group, has previously been shown to have less nephro-toxicity and higher water …
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Inhibition of Cysteine Protease by Platinum (II) Diamine Complexes
… of how the size and shape and leaving ligands of platinum complexes affect cysteine protease, papain enzyme are studied. This could give new ways to optimize anticancer activity. The activity of papain enzyme was measured on UV-Visible spectroscopy. The inhibition profile of papain with different …
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