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Showing 1 to 4 of 4 for “"platinum anticancer drugs"”.
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Cellular responses against DNA damaged by platinum anticancer drugs
The anticancer activity of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is mediated by their ability to attack DNA such that generated adducts trigger numerous cellular responses. A better understanding of these processes is critical for developing more effective therapeutic …
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Non-traditional platinum compounds for improved cellular accumulation and tumor targeting
Chapter 1. Introduction to Non-Traditional Platinum Compounds for Improved Uptake, Oral Bioavailability, and Tumor Targeting The path to more potent platinum anticancer drugs with fewer side effects lies in the exploration of non-traditional platinum compounds, which do not necessarily contain the …
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Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention
… potential use of proteasome inhibitors as novel anticancer drugs. The widespread clinical success of platinum-containing drugs served as a catalyst for investigating other metal complexes for the treatment of human cancer. In an effort to improve upon the limitations of platinum anticancer drugs, …
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A Study on the Protein Interaction with Different Platinum Compounds
… metastatic or advanced cancer with cisplatin and platinum compounds. Platinum compounds covalently bind to DNA and disrupt DNA function. They are also known to bind with amino acids like methionine, histidine and cysteine to form cisplatin-protein adducts which are responsible for most of its …