Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 28 for “"platinum(II) complexes"”.
-
NEW NCN-PLATINUM(II) COMPLEXES WITH LUMINESCENT PROPERTIES
… and characterization of novel NCN-based platinum(II) complexes, obtaining more than twenty completely new compounds. These complexes have a terdentate chelating ligand with the general scaffold of a 1,3-di(2-pyridyl)benzene and were designed following different strategies: i) Complexes …
-
A spectroscopic study of square planar platinum (II) complexes
… in the structural analysis of square planar Pt(II) complexes.
-
Pyrolysis and Hydrolytic Cleavage of Vinyl- and Allylsilane Platinum (II) Complexes
No abstract prepared.
-
Pyrolysis and Hydrolytic Cleavage of Vinyl- and Allylsilane Platinum (II) Complexes
No abstract prepared.
-
Exploring the binding of amine and sulfonamide ligands in Rhenium(I) Tricarbonyl and Platinum(II) complexes
Platinum is the metal present in various classes of inorganic medicinal agents directed at important diseases such as cancer or viral infections. Several new Pt(II) complexes of polyamine ligands bearing a dansyl moiety linked by a sulfonamide group were prepared; in some cases the sulfonamide …
-
Pyrazole and pyrazolyl palladium(II) and platinum(II) complexes: synthesis and in vitro evaluation as anticancer agents
The use of metallo-pharmaceuticals, such as the platinum drugs, for cancer treatment illustrates the utility of metal complexes as therapeutic agents. Platinum group metal complexes therefore offer potential as anti-tumour agents to fight cancer. This study was aimed at synthesizing and evaluating …
-
Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity
Malaria remains one of the largest parasitic disease burdens worldwide, with the vast majority of that burden occurring on the African continent. The ongoing high number of malaria cases and deaths is in part attributable to the emergence and spread of resistance to most clinical chemotherapeutics. …
-
Synthesis and Characterization of Carbon Monoxide Producers Bipyridine Flavonolate Palladium(II) and Platinum(II) Complexes: Potential Anti-Cancer Agents
<p>Novel designed metal ligand complexes as prodrugs are useful in the effort to find more effective and selective anti-cancer<strong> </strong>treatments. Carbon monoxide, CO, is known to induce mitochondrial collapse in cancer cells. Herein is described the synthesis of seven novel bipyridine …
-
Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment
… novel anti-malarial drugs, a series of planinum (II) complexes were synthesised, their association with haematin determined in 40 aqueous DMSO, pH 7.4 at 25°C and their ability to inhibit the formation of β-haematin (synthetic malaria pigment) was investigated. The compounds synthesised and …
-
Synthetic strategies for the design of platinum anticancer drug candidates
Chapter 1. The Synthetic Chemistry of Platinum Anticancer Agents Since the inception of cisplatin as a clinically approved anticancer agent, a large number of platinum compounds have been synthesized with the aim of finding new, improved drugs. As a result of these efforts, only two additional …
-
The synthesis, characterization and reactivity of metallacycloalkanes and their precursors
A series of bis(alkenyl)platinum(II) complexes of the type [PtL2{(CH2)nCH=CH2h](L2 = 1 ,3-bis( diphenylphosphino )propane and n = 3-6) have been successfully synthesized and characterized by IH, I3C and 31p NMR spectroscopy, elemental analysis and mass spectrometry. I3C NMR data for these complexes …
-
Developments in the chemistry and nanodelivery of platinum anticancer agents
… receiving cancer chemotherapy are treated with a platinum-containing drug. Despite this intense clinical use, only three platinum complexes, cisplatin, carboplatin, and oxaliplatin, are approved by the United States Food and Drug Administration for the treatment of cancer. A number of side effects …
-
The preparation of the coordination compounds of platinum (II) and arginine, histidine, lysine, and serine
… the preparation of the coordination compounds of platinum (II) and four alpha-amino acids, namely arginine, histidine, lysine, and serine. A first analysis of the problem would seem to indicate that the preparations should be straightforward and not difficult. Bailar (3) stresses the great …
-
Inhibition of Cysteine Protease by Platinum (II) Diamine Complexes
… of how the size and shape and leaving ligands of platinum complexes affect cysteine protease, papain enzyme are studied. This could give new ways to optimize anticancer activity. The activity of papain enzyme was measured on UV-Visible spectroscopy. The inhibition profile of papain with different …
-
NEW ORGANOMETALLIC COMPLEXES WITH PHOTOLUMINESCENT AND NON LINEAR OPTICAL PROPERTIES
… luminescent properties, organometallic complexes of transition-metals have recently received considerable attention as phosphorescent emitters for Organic Light Emitting Diodes (OLEDs). In particular, various platinum(II) complexes with a cyclometallated 1,3-di(2-pyridyl)benzene ligand …
-
Palladium and platinum complexes of trans-coordinating bidentate phosphine ligands
… (PP), have been used in the preparation of complexes described in this work. Construction of molecular models proved useful in predicting the likely geometries of the complexes. For example, the ligand PP is capable of chelating trans- but not cis- in a mononuclear fourcoordinate …
-
High Pressure Liquid Chromatography Studies of the Reaction of Platinum Complexes with Peptides
Platinum complexes (cisplatin, carboplatin and oxaliplatin) are effective anticancer agents. However the major drawbacks of platinum chemotherapy are toxic side effects and resistance. The affinity of platinum complexes to sulfur donor ligands of side chains of methionine and cysteine amino acids …
-
Biomolecular interactions and cellular effects of steroidal and metallosupramolecular metallodrugs
… synthesis of new steroidal DNA covalent-binding platinum(II) complexes together with techniques to purify previously synthesised steroidal complexes are presented. Their cytotoxicity, cellular uptake and biomolecular interaction are investigated, showing that the coupling of the steroid confers …
Page 1 of 2