Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 313 for “"platelets"”.
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Platelets : their exploitation and elimination
Platelets are cytoplasmic fragments present in large numbers within the bloodstream that contain a multitude of proteins. For a long time, platelet function was believed to be limited to the essential functions of haemostasis and thrombosis. However, it has become clear in the last decade that …
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Platelets : their exploitation and elimination
Platelets are cytoplasmic fragments present in large numbers within the bloodstream that contain a multitude of proteins. For a long time, platelet function was believed to be limited to the essential functions of haemostasis and thrombosis. However, it has become clear in the last decade that …
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The Regulation of Phosphorylation Events in Platelets
Platelets play a vital role in processes of hemostasis and thrombosis under physiological and pathological conditions. Following vascular damage, platelets will accumulate and stably adhere to exposed subendothelial matrixes. The binding of platelet surface receptor Glycoprotein VI (GPVI) to …
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The Role of Platelets In Ovarian Carcinoma
Platelets represent one of the largest storage pools of angiogenic and oncogenic growth factors in the human body. The observation that thrombocytosis (platelet count >450,000/uL) occurs in patients with solid malignancies was made over 100 years ago. However, the clinical and biological …
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Targeting phosphatidylserine exposure in pro-coagulant platelets.
Pro-coagulant platelets are a subpopulation of activated platelets that are central to blood clot formation in both thrombosis and haemostasis. They expose the anionic phospholipid, phosphatidylserine (PS), in their outer leaflet enabling coagulation complex assembly on the negatively charged …
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Mechanisms of microparticle release from human platelets
Platelets release a variety of extracellular vesicles, including platelet-derived microparticles that expose phosphatidylserine on their surface. This thesis aims to resolve the mechanisms by which pro-thrombotic microparticles are released from platelets, which have not been well-characterised. …
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Sequestration of rabbit platelets labelled with Cr⁵¹
Thesis: B.S., Massachusetts Institute of Technology, Department of Chemistry, 1960
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… released upon platelet activation. ADP activates platelets through two purinergic receptors namely P2Y1 and P2Y12 these receptors couple to Gq and Gi class of G-proteins, respectively. P2Y1 causes calcium mobilization through activation of PLC-β. P2Y12 inhibits adenylyl cyclase, causes activation …
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Platelets and Anti-Angiogenic Resistance In Ovarian Carcinoma
… clinical impact of anti-angiogenic. Platelets represent a component of the tumor microenvironment that are implicated in metastasis and represent a significant reservoir of angiogenic regulators. Thrombocytosis has been shown to be caused by malignancy and associated with adverse …
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The Use of Synthetic Platelets to Augment Hemostasis
Uncontrolled hemorrhage comprises 60-70% of trauma-associated mortality in the absence of other lethal conditions (e.g. damage to central nervous or cardiac system). Immediate intervention is critical to improving chances of survival. While there are several products to control bleeding for …
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Studies of calcium signalling mechanisms in human platelets
… to enable a variety of platelet responses. In platelets and other non-excitable cells, the major route of Ca2+ entry occurs as a result of Ca2+ depletion from intracellular stores, and is known as store operated Ca2+ entry (SOCE). STIM1 is the Ca2+ sensing protein of the endoplasmic reticulum …
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Label-Free Functional Imaging Of Platelets At Nanoscale
… dysfunction. The mechanical properties of platelets inform the formation of haemostatic plugs that have wide application in bleeding disorders and cardiovascular diseases. During clotting, individual platelets sense physical and biochemical agonists on their surface receptors that trigger …
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Label-Free Functional Imaging Of Platelets At Nanoscale
… dysfunction. The mechanical properties of platelets inform the formation of haemostatic plugs that have wide application in bleeding disorders and cardiovascular diseases. During clotting, individual platelets sense physical and biochemical agonists on their surface receptors that trigger …
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The role of platelets and leukocytes in endogenous fibrinolysis.
… of intravascular aggregation of circulating platelets and white blood cells on the plasma activity of t-PA and PAI-1 was measured. In vivo platelet and white blood cell aggregation was induced by platelet and white blood cell agonists, the effect being monitored by the Technicon autocounter. …
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Platelets and their immunomodulatory roles during Streptococcus pyogenes infection
… rapidly responding cells in our bloodstream are platelets and they are a main focus for the studies presented in this thesis and have been investigated. The overall aim of this thesis was to delineate and understand the role of platelets, neutrophils and endothelial cells in response to bacterial …
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Regulation of Protein Kinases (Syk and PKC zeta) in platelets
Platelets are crucial components of the hemostatic machinery of the body. When the endothelial continuity is disrupted due to injury or atherosclerotic plaque rupture, one of the earliest responses to arrest the bleeding is the adhesion of circulating platelets to the exposed subendothelial …
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BIOCHEMICAL AND MORPHOLOGIC EFFECTS OF CAVITATION ON NORMAL HUMAN PLATELETS
… the physical and biochemical response of platelets subjected to well-defined vaporous cavitation near a decelerating prosthetic surface. Also examined was the hypothesis that two types of shear stress transients, lytic and sublytic, are responsible for platelet lysis, aggregation and …
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The role of megakaryocytes and platelets in infection and immunothrombosis
… a primary role in hemostasis as precursors to platelets, which are importantly, one of the most abundant cell types in the peripheral circulation. While platelets are studied for their various roles in inflammation, the role of MKs within the innate immune system has not been explored. In a …
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The Requirement for Viable Platelets in the Coagulation of Heparinized Blood
… blood or plasma samples containing normal platelets were compared with ACT’s of heparinized samples containing non-viable or abnormally functional platelets. The non-viable platelets were prepared by freeze/thawing, and the abnormally functional platelets resulted from the addition of …
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