Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"platelet-derived growth factor"”.
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Characterization of an Alternatively Spliced Platelet-Derived Growth Factor Variant During Myelin Synthesis
An alternatively spliced platelet-derived growth factor (PDGF) A-chain isoform was detected in rat dorsal root ganglion (DRG) neuron/Schwann cell cocultures and shown to regulate myelin synthesis. mRNA transcripts of the long-form PDGF-A chain variant (LF-PDGF-A) were detected by RT-PCR in …
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Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
… pathways and mechanisms regulating epicardial derived cell (EPDC) development remain largely unknown. Using mice with epicardial specific deletions of the PDGF receptors, I discovered that these receptors control EPDC fate and epicardial EMT. I demonstrated that each receptor was required for …
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Investigation of the role of Platelet-Derived Growth Factor (PDGF) in the development of breast carcinomas
Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, September 2002.
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Untersuchung über die scherstressabhängige Induktion des platelet-derived growth factor mit Hilfe eines Reportergen-Assays an transfizierten Endothelzellen
Untersuchung über PDGF und seine Reaktionskinetik an transfizierten Endothelzellen bei Scherstress
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Transforming Growth Factor Beta1 und Platelet Derived Growth Factor im Serum und in bronchoalveolärer Lavage bei idioapthischen Lungenfibrosen
… Spiegel der profibrotische Zytokine Transformig Growth Factor ß1 (TGF ß1) und Platelet Derived Growth Factor AB (PDGF-AB) im Serum und in der Bronchoalveolären Lavagenflüssigkeit (BALF) von 87 Patienten mit ILD mittels ELISAs. Dann suchten wir nach Korrelationen zu klinischen Parametern. Bei der …
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Involvement of Platelet-Derived Growth Factor, PDGF Receptor Signaling, Focal Adhesion Kinase and SRC in Pressure-Induced Vascular Smooth Muscle Hypertrophy
… we targeted cell surface integrin and growth factor receptors thought to be mechanically sensitive. The signaling molecules FAK, Src and ERK-MAPK are known to be triggered by integrin engagement and growth factor receptor tyrosine kinase (RTK) activation. Pairs of rat mesenteric …
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Stromal Derived Growth Factor Alpha (Sdf-1Α) Induces The Differentiation of Bone Marrow Progenitor Cells (Bmcs) Into Pericytes By Regulating Platelet Derived Growth Factor B (Pdgf-B) Transcription
… vasculogenesis, is essential for Ewing’s sarcoma growth with the soluble vascular endothelial growth factor, VEGF<sub>165</sub>, being the chemotactic factor for BMC migration to the tumor site. Inhibiting VEGF<sub>165</sub> in TC71 tumors (TC/siVEGF<sub>7-1</sub>) inhibited BMC infiltration to …
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Interactome Analysis Identifies Novel Targets of Phosphoinositide 3-kinase (PI3K) that Mediate Astrocyte Neuroprotection
… included expected PI3K interactors, such as the platelet-derived growth factor receptor A (PDGFRA), and novel interactors, such as the zinc finger CCCH-type containing 14 (ZC3H14). ZC3H14 has recently emerged as an important RNA binding protein that modifies poly-adenosine tail lengths on nascent …
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Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
In addition to steroid hormones, signaling by platelet-derived growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities …
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Chemotaxis of Central Nervous System-derived Tumor Cells within Controlled Microenvironments
… in vitro migratory and cellular responses of MB-derived cells to external signaling of Epidermal Growth Factor (EGF), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF-BB), and the stromal cell-derived factors 1-alpha (SDF-1). Experiments utilized transwell assays and …
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The Regulation and Mechanism of Myelin Synthesis Involving Endogenous Steroid Hormones
In conjunction to the previous study, the platelet-derived growth factor (PDGF) A-chain was detected as two distinct splice variants in Schwann cell/neuronal co-cultures. Both PDGF A-chain isoforms were characterized and examined throughout the myelination process. The mRNA for the long form PDGF …
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Discovery of Pyrimidine-based Heterocycles as Single Agents With Combination Chemotherapy Potential And As Inhibitors Of Purine Nucleotide Biosynthesis For The Treatment of Cancer
… tyrosine kinases (RTKs)- vascular endothelial growth factor receptor-2 (VEGFR2), platelet derived growth factor receptor-β (PDGFRβ) and epidermal growth factor receptor (EGFR) in single entities. Single agents with both antiangiogenic activities as well as cytotoxicity would afford agents that …
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Sensory Primary Cilium is a Distinct Signaling Compartment
… pathways such as Hedgehog (Hh), Wnt, and platelet-derived growth factor (PDGF) pathways during development and tissue homeostasis. The primary cilium has been established as a mechano, chemo- and osmosensing unit that transmits extracellular cues to the cell, which supports the importance …
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PDGFRalpha Signaling Requirements in the Development of Tissues Derived From Sclerotome and Dermatome
The Platelet-Derived Growth Factor Receptors (PDGFR) play roles in the development of multiple mesenchymal cell types. Upon ligand binding, the receptors signal through a number of intracellular signaling molecules and elicit many cellular responses including migration, proliferation, and …
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An integrated process for the recovery of clinically significant trace proteins from human plasma
Methods for the preparation of concentrates of factor VIII, factor IX, high purity factor IX, Cl esterase inhibitor, specific immunoglobulin and platelet factor XIII are described. These procedures were developed or modified with the aim of integration into an automated process that would allow …
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… and differentiation of cells that express platelet-derived growth factor receptor alpha (PDGFRA), CD34 and Sca1 (PDGFRA+ cells). PDGFRA+ cells have a unique morphology in which extended processes contact multiple cells in the tissue microenvironment. Surprisingly, these cells also give rise …
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Die Plasmamembran-Kalzium-ATPase im Myokard
… mit fetalem Kälberserum, Noradrenalin und dem Platelet Derived Growth Factor BB, jeweils im Vergleich zwischen transgenen und Wildtyp-Kardiomyozyten. Dabei zeigte sich ein beschleunigtes Wachstum der PMCA-überexprimierenden Zellen. In einem zweiten Ansatz wurden Untersuchungen angestellt, um …
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Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression
<p>Platelet Derived Growth Factor (PDGF) is a family of mesenchymal growth factors that regulate cell proliferation, migration, and differentiation. Unlike the classic PDGF ligands A and B, which are secreted as active dimers, PDGF D must undergo extracellular proteolytic processing to remove its …
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Characterisation of cytokine secretion in malignant gliomas
… groups. These were follistatin, fibroblast growth factor (FGF), granulocyte – colony stimulating factor (G-CSF), soluble human epidermal growth factor receptor 2 neural (sHER2neu), soluble interleukin-6 receptor alpha (sIL-6R alpha), platelet-derived growth factor - AABB (PDGF-AABB), …
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A Microfludic Assay Device for Study of Cell Migration on ECM-mimicking Suspended Nanofibers in Presence of Biochemical Cues
… mouse embryonic fibroblast NIH/3T3 response to platelet derived growth factor (PDGF) on flat polystyrene and suspended, polystyrene nanofibers with small (15 μm), and large (25 μm) spacing. Cell aspect ratio is lowest for flat polystyrene (spread morphology) and highest for large-spaced fibers …
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