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Showing 1 to 3 of 3 for “"platelet granules"”.
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Engineering rFVIIa-loaded platelets; a novel approach to treating acute bleeding
… products such as fresh frozen plasma, as well as platelet transfusion and recombinant clotting factors such as rFVIIa. However, the use of recombinant clotting factors is limited due to cost and adverse side effects resulting from increased thrombosis, such as increased rate of myocardial …
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Disabled-2 regulates platelet heterotypic and homotypic aggregation through sulfatide binding
At the site of vascular injury platelet aggregation serves to stem blood flow, initiate the inflammatory response, and stimulate wound healing. Platelets become stimulated, release their granule contents, and become adherent to one another. Platelet granules contain important clotting factors and …
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The role of Nbeal2 in the homeostasis and retention of granules in haematopoietic cells
Gray platelet syndrome (GPS) is a rare disorder primarily characterised by the absence of α-granules in platelets. Typical clinical features of GPS include macrothrombocytopenia, abnormal or excessive bleeding, splenomegaly, and bone marrow fibrosis. GPS is caused by biallelic mutations in the …