Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"platelet disorders"”.
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Genetic and functional studies in inherited platelet disorders
Platelets are anucleate blood cells containing secretory granules, which play a critical role in haemostasis, atherogenesis, thrombosis, and wound healing. Platelet number, volume, and function are genetically regulated, and genome wide association studies have identified more than 1000 loci …
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Impact of cocoa (Theobroma cacao L.) fermentation on composition and concentration of polyphenols: Development of fermentation model system and utilization of yeast starter cultures
… disease, inflammation, diabetes, obesity, and platelet disorders. Cocoa polyphenols, putatively responsible for these beneficial activities, are highly impacted by cocoa variety, agronomic effects and processing history. However, the difference in polyphenol concentration and composition …
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Study of patients with suspected platelet-based bleeding disorders: a search for patients with a defect in the P2Y12 ADP receptor
Mild platelet-based bleeding disorders are among the most complex bleeding disorders to understand, due to the absence of a ‘gold standard’ test for diagnosis and the significant overlap with the bleeding phenotype observed in healthy individuals. The work in this thesis is focussed on patients …
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Investigating the role of rare genetic variants in the aetiology of haemostasis disorders
… the genetic bases for thousands of Mendelian disorders have been identified. However, providing a molecular diagnosis for these conditions remains challenging, and a considerable portion of patients with inherited conditions still lack a genetic diagnosis. In clinical genomics, identifying the …