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Showing 1 to 5 of 5 for “"platelet biology"”.
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Roles of coagulation factor XIII in the functions of blood platelets
… of blood. It involves concerted actions of blood platelets and soluble coagulation factors in forming blood clots at sites of vascular injury. Platelets are recruited from flowing blood and become activated to fulfil their haemostatic roles (Marcus, 1969, Ruggeri and Mendolicchio, 2007). …
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Platelets : their exploitation and elimination
Platelets are cytoplasmic fragments present in large numbers within the bloodstream that contain a multitude of proteins. For a long time, platelet function was believed to be limited to the essential functions of haemostasis and thrombosis. However, it has become clear in the last decade that …
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Platelets : their exploitation and elimination
Platelets are cytoplasmic fragments present in large numbers within the bloodstream that contain a multitude of proteins. For a long time, platelet function was believed to be limited to the essential functions of haemostasis and thrombosis. However, it has become clear in the last decade that …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
Platelets orchestrate haemostasis through receptor-mediated adhesion, aggregation, and secretion. Platelet dysfunction can lead to bleeding and/or clotting disorders but is challenging to diagnose clinically. This thesis focuses on immune thrombocytopenia (ITP), a disorder marked by immune-mediated …
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Cytokine receptor-like factor 3 (CRLF3): A novel regulator of platelet biogenesis and potential drug target for thrombocythaemia
Thrombocythaemia is defined as a circulating platelet count above 450x10$^9$/L in humans. The major cause of thrombocythaemia is reactive $(secondary)$ thrombocythaemia which occurs secondary to many conditions such as infection, cancer and inflammation. However, acquired clonal mutations in mainly …