Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"platelet adhesion"”.
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Platelet adhesion in atherogenesis
Platelets are known to play a key role in acute coronary events, such as myocardial infarction, associated with advanced atherosclerosis, but a number of papers have recently been published suggesting that platelet adhesion may initiate atherosclerotic lesion formation. The proposed research aimed …
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A Physio-chemical Predictive Model of Dynamic Thrombus Formation and Growth in Stenosed Vessels
… mediation. Shear stress plays a major role in platelet-substrate interactions and thrombus formation and growth in blood flow, where under both pathological and physiological conditions platelet adhesion and accumulation occur. In this study, a three-dimensional dynamic model of platelet-rich …
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Die Rolle der Thrombozyten- und Leukozyten-Endothelzell-Interaktion in der Atherogenese
… - an in vivo-study in the ApoE-knock-out-mouse - Platelets play a crucial role in thromboembolic complications of advanced atherosclerotic lesions but their involvement in the initiation of the atherosclerotic process in unclear. Platelet adhesion regulates secretion of intracellulary stored …
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Roles of coagulation factor XIII in the functions of blood platelets
… that stabilises fibrin clots and associates with platelets. In the present study, the role of factor XIII (FXIII) in modulating physiological platelet functional responses including adhesion, signal transduction and spreading were examined. Under static conditions, platelets adhered to …
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Comparative effect of haemodynamic variables and rheological properties of the blood on the margination and adhesion of leukocytes and platelets
… blood, had on the behaviour of leukocytes and platelets. By varying shear rate and stress, blood haematocrit, and aggregation and deformability of red cells, we obtained evidence that leukocyte adhesion was dictated by the number of free-flowing cells 'marginated' near the vessel wall and the …
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The determination of hemocompatibility of a geometrically-altered poly(dimethylsiloxane) surface
… manufactured via a polymer casting process, a platelet adhesion assay was developed to assess the relative hemocompatibility of the surface via number of platelets counted on the surface of the altered vs. unaltered PDMS. Apparent contact angles of blood and Platelet-Rich Plasma (PRP) on the …
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Hemocompatible polymer thin films fabricated by Electrostatic Self-Assembly (ESA)
… evaluate the hemocompatibility of the coatings. Platelet adhesion study showed the thin films inhibited platelet adhesion. All thin films were able to inhibit coagulation and were less cytotoxic. The studies suggested the ESA films were potentially hemocompatible.
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Vasomotor and anti-oxidant effects of anti-ischaemic therapies.
… vascular homeostasis including vasomotor tone, platelet adhesion and aggregation. The current studies examine various aspects of NO responses, including: the methodology for assessment of vascular NO responses, and identification of factors reponsible for poor responsiveness and pharmacological …
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Hemocompatibility of polymeric materials for blood-contacting applications
… assay. The results were visualized using SEM. Platelet adhesion and activation was investigated using live cell staining and SEM. Whole blood clotting kinetics were evaluated using a hemolysis assay and the results visualized using SEM. The results indicate that none of these materials are …
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Improving hydrophilicity of silicone elastomer by IPN formation with hyaluronan
… fields, the material was also tested for platelet adhesion/activation and whole blood clotting. However, studies showed unfavorable results as the treated samples still caused platelet activation and blood clotting. Additionally, overall optical transmittance of the treated materials was …
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The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.
… factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active …
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Adsorption of Blood Proteins onto Polysaccharide Surfaces
… to investigate the adsorption behavior of two platelet adhesion-related blood proteins, human serum albumin (HSA) and human serum fibrinogen (HSF), on two polysaccharide materials used for hemodialysis membrane applications: regenerated cellulose and cellulose acetate. The study aims to provide …
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The platelet laminin receptor : discovery of a 67kDA receptor for laminin on the membranes of human platelets : characterisation and isolation
Previous work on the binding of resting platelets to the basement membrane glycoprotein, laminin, has identified the Ic/IIa integrin c01aplex (CD49f/CD29), also known as VLA-6, as the receptor. There exists however, another protein with a molecular weight of 67kDa, that mediates this function on …
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The role of platelets and their associated recruitment mechanisms, in intestinal ischaemia reperfusion injury
Recent studies have demonstrated a key role for platelets and microthrombi in the pathophysiology of intestinal ischaemia-reperfusion (IR) injury. The research described in this thesis investigates the role of the major platelet glycoprotein receptors in recruiting and activating platelets …
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The development and application of an in vitro model of coronary lesion thrombosis
… and spatial flow perturbations on local site platelet adhesion. Not only do such variations create quantitative differences in local reactions, but qualitative differences as well as various receptors must interact to create stable adhesions in a given hemodynamic environments. These findings …
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The wettability of biomaterials determines the protein adsorption and the cellular responses
… of the adsorbed protein layer determines whether platelets will adhere and become activated or not on the artificial surface and thus to complete the thrombus formation. The adsorption of fibrinogen (FNG), which is present in plasma, has been shown to be closely related to surface induced …
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Improving blood compatibility of surfaces using tanfloc and carboxymethyl-kappa-carrageenan polyelectrolyte multilayers
… of CMKC compared to heparin (HEP) in reducing platelet adhesion, activation, and whole-blood clotting. Structural similarity of CMKC to HEP, coupled with its sustainable and animal-free origin, highlights its potential as a safer anticoagulant alternative. The third aim examines …
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Mechanistic Investigation of A Hemostatic Keratin Biomaterial
… two probable mechanisms; integrin mediated platelet adhesion and increased fibrin polymerization.
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Surface Modification of Commonly used Polymer Plastics for Increased Hemocompatibility in Medical Equipment
… s−1. Most MEG-OH covered plastics had >90% less platelet adhesion than bare plastics, the result was repeated on all exposure times and shear rates. Surface protein composition was analyzed by SDS–PAGE. First trails using MEG-OH on PVC as an implant material for cranial windows on rats decreased …
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Analysis of signal transduction pathways and the cytoskeleton in VASP-deficient cell lines and mouse models
… of Listeria and the establishment of cell-cell adhesion. Moreover, Ena/VASP proteins have been implicated as inhibitory factors in repulsive axon guidance and inhibition of plasma membrane activity and random motility in fibroblast. In order to study the physiological function of VASP, …
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