Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"plasminogen activation"”.
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Role of Thrombin-Activatable Fibrinolysis Inhibitor in Breast Cancer Metastasis and Angiogenesis
… cleaving carboxyl terminal lysine residues from plasminogen binding sites on cell surface receptors, which are important in accelerating plasminogen activation to plasmin. We have demonstrated that TAFIa is able to inhibit metastatic behaviours, including breast cancer cell invasion, migration …
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Design and synthesis of small-molecule inhibitors as anti-malarial and anti-serpin agents
… most virulent malarial parasite in humans, and plasminogen activator inhibitor-1 (PAI-1), an endogenous serine proteases inhibitor implicated in a wide range of biological processes. Malaria is one of the top global health threats, and there is a great need for developing effective new …
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Multiscale Mathematical Modelling of Cancer Invasion
… matrix metalloproteases (MMP) and the urokinase plasminogen activator (uPA).<br/><br/>This thesis has investigated the complex process of cancer growth and spread that occur across several different spatial scales, in order to gain a better understanding of the key processes involved during …
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The Role of The Plasminogen-Fibrin Interaction in The Regulation of Fibrinolysis
… The major components of the fibrinolytic system, plasminogen and plasminogen activator, are known to co-exist in the blood but the biochemical details of how the proteolytic system is regulated to restrict plasmin formation to the sites of fibrin clots are not well understood. A possible mechanism …
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Cerebral Amyloid Angiopathy-Causing Beta-Amyloid Variants Have Altered Effects on the Clotting System
… enhancements to proteolytic/fibrinolytic system activation, I examined the effects of HCAA Aβ on the fibrinolytic system. I found that the majority of HCAA Aβ variants led to increased tPA-mediated plasminogen activation. The HCAA Arctic variant (E22G) did not, which may partially explain the …
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Proteolytic mechanisms involved in the metastasis of human melanoma cells
… which could contribute to the process, plasminogen activation by tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) is one such mechanism. Extensive reports in the literature (reviewed in the introduction) indicate that most tumour cells synthesize uPA and that …
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Dissection of receptor functions through the generation of a tcu-PA cleavage resistant u-PAR: a u-PA independent active u-PAR
… wound healing, and tumor invasion. Urokinase plasminogen activator receptor (u-PAR) has been widely studied in both systemic and cellular processes. Systemic roles for u-PAR include angiogenesis, inflammation and cancer while cellular roles include cell proliferation, survival, adhesion, …