Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"plasmacytoid dendritic cells"”.
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Plasmacytoid dendritic cells & immunotherapy of cancer
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Plasmacytoid Dendritic Cells Sense Skin Injury and Promote Wound Healing Through Type I Interferons
Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells, which selectively express intracellular Toll-like receptors (TLR)-7 and TLR-9 and have the capacity to produce large amounts of type I IFNs (IFN-a/b) in response to viruses or host derived nucleic acid containing …
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Studies on the Interaction between Porcine Plasmacytoid Dendritic Cells and Porcine Reproductive and Respiratory Syndrome Virus
… production in response to a viral infection, the plasmacytoid dendritic cell (PDC), had been largely ignored. Conceivably, this dismissal was based on the fact that a subset of AM is the principal target cell of PRRSV and that these cells readily support its replication in vitro. Because of the …
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Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
… altered gene expression patterns of the immune cells. By studying these patterns through gene expression profiling it is possible to describe not only the current states the cells are in, but also to extrapolate the proximal signals that resulted in the observed patterns. In the studies …
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The Biology of Dendritic Cells in the Context of Autoimmunity
… and flares is poorly understood. Because plasmacytoid dendritic cells (pDCs) are the primary type I IFN producers, their role in SLE has long been suspected, with murine pDC depletion models successfully delaying the progression of murine lupus-like disease. However, the mechanism behind …
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Insights into the Iimmune Mechanisms Leading to Lupus-like Autoimmunity in New Zealand Black Mice
… Polyclonal B cell activation, expansion of plasmacytoid dendritic cells (pDC), and elevated gene expression of baff were maintained in CD40L-deficient NZB mice, despite the lack of IgG immune complexes. Chapter 3 utilizes bicongenic mice carrying both NZB chromosomes 1 and 13 to investigate …
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Targeting of specific developmental pathways to understand dendritic cell heterogeneity and function
Dendritic cells (DC) are cells of the immune system that are specialized in sensing and responding to pathogens. They coordinate innate and adaptive immune responses to different types of pathogens through the release of inflammatory cytokines, secretion of interferon, and presentation of antigen …
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The Role of LIFR Signaling in Innate Immunity
… signals that bone marrow (BM) hematopoietic stem cells (HSCs) and immune cells receive are critical in regulating their responses in the steady state and inflammation. Monocytes are an abundant and key population in the innate immune response that originates in the BM, and they circulate to …
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… production of pathogenic autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus (SLE), a prototypic systemic humoral autoimmune disease. However, the cellular events that …
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The Expression of the Zinc Finger Transcription Factor zDC Defines the Classical Dendritic Cell Lineage
<p>Classical dendritic cells (cDCs) are a critical component of the immune system due to their roles in the maintenance of immune tolerance and the induction of adaptive immune responses. However, distinguishing cDCs from other myeloid populations is complicated by the lack of highly specific cDC …
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Viral and Cell Type Specific Host Factors that Contribute to Paramyxovirus Antiviral Responses
… persistent infections of cultured epithelial cells with minimal induction of host cell responses. In contrast, two SV5 mutants induce production of proinflammatory cytokines, type I interferon, and cytopathic effects. The SV5 mutant, Le-(U5C,A14G), contains naturally occurring nucleotide …
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Immune Recognition of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity
… of the Toll-like receptors (TLRs) in the dendritic cells (DCs). However, in psoriasis plasmacytoid dendritic cells have been found to be able to sense self-DNA molecules in complex with the endogenous cationic antimicrobial peptide LL37, which are internalized into the endosomal …
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Down-Regulation of Natural Killer Cell Activation in Response to Influenza Virus in Older Adults
… infection and vaccination. Natural killer (NK) cells secrete significant amount of IFN-7 , a hallmark Thl cytokine, in response to influenza infection. How aging influences human NK cell IFN-7 production in response to influenza virus has not been well documented. In this study we employed human …
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The CD4⁺ T Cell Response to Human Cytomegalovirus
… the responses of peripheral blood mononuclear cells (PBMCs), CD4+ cells, CD8+ T cells, and natural killer (NK) cells to HCMV infection of autologous fibroblasts in healthy HCMV-seropositive and HCMV-seronegative adults, and showed that there were inherent differences in the ability to control …
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The Role of Histone Deacetylase 6 Inhibition on Systemic Lupus Erythematosus
… important molecular pathways in diverse immune cells. Both innate and adaptive immune cells contribute to pathogenesis of lupus. Among those cells, B cells play a central role in pathogenesis of lupus nephritis in an anti-body dependent manner through differentiation into plasma cells (PCs). As …
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Mechanistic Insights on The Immunomodulatory Functions of Diverse Environmental Factors on Systemic Autoimmunity
… VAD enhanced early activation of plasma cells and augmented their autoantibodies production. In addition, VAD led to an enhanced expansion of pathogenic T lymphocytes. In parallel, VAD increased renal infiltration of conventional and plasmacytoid dendritic cells. Our findings establish …
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Interaktion des Frühsommer-Meningoenzephalitis- Virus mit antigenpräsentierenden Zellen
Zusammenfassung Das Frühsommer-Meningoenzephalitis-Virus (FSME-Virus) gehört zu der Familie der Flaviviren und ist innerhalb Europas das am weitesten verbreitete von Arthropoden übertragene Virus. Eine Infektion des Menschen mit dem FSME-Virus erfolgt zumeist über den Stich einer infizierten Zecke …