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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"plasma protein"”.
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Plasma protein binding of vitamin B₁₂
[Typescript]; 239 leaves
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The functions of pregnancy-associated plasma protein A in rheumatoid arthritis.
Pregnancy associated plasma protein A (PAPP-A) is produced in increasing amounts with advancing pregnancy, a major source being the placenta. It was originally described as a homotetramer with ~ 200,000 M[r] subunits. An alternative structure has since been proposed of a disulphide bridged complex …
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The molecular characterisation of pregnancy-associated plasma protein-A (PAPP-A).
PAPP-A is a large glycoprotein with alpha2-electrophoretic mobility that is produced by the placenta during pregnancy. In this thesis a biochemical and molecular characterisation of PAPP-A was performed. The polyclonal antiserum (DAKO) directed against PAPP-A has been shown to also interact with …
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Amino acid supplementation of calf milk replacers containing bovine plasma protein
… formulations for preweaned calves use milk protein sources (now principally whey proteins) because of their high digestibility, desirable amino acid profile, and lack of anti-nutritional factors. Over the course of the past five years the price of milk-based proteins has continued to …
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The plasma protein fetuin: common structural features of the mammalian fetuin family
… and tissue-specific expression of the bovine plasma glycoprotein fetuin and its homologues in other species has been examined. From the known partial amino acid sequence of bovine fetuin, degenerate oligonucleotide probes were designed. These probes were end-labelled using 14 polynucleotide …
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Defining the range for plasma protein incorporation in milk replacer for dairy calves
… replacer containing from 0% to 100% of the total protein from porcine plasma protein, with or without isoleucine balanced, on calf growth and health. Four groups of 31 male Holstein calves were blocked by initial BW and plasma protein concentration and assigned to one of seven treatments. …
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Molecular interactions in pharmaceutical preformulation and supramolecular complexes. Structural properties governing drug-plasma protein binding and investigation of amino acids co-crystals
… in the formulation. The study of drug-Plasma Protein Binding (PPB), and the lipophilicity, solubility, and ionic behaviours of the desired drug molecules addresses the gap and enhances our undertraining related to the behaviour of the drug molecules in the body. The High-Performance …
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Phosphorus bioavailability and digestibility in soybean meal, spray dried plasma protein and meat and bone meal determined by different methods in poultry
… for soybean meal (SBM), spray dried plasma protein (SDPP), and meat and bone meal (MBM) using different types of assays in poultry. Experiment 1 evaluated the precision-fed rooster assay and determined the effects of increasing P intakes on excreta P retention values using corn and …
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Evaluation of the Pharmacokinetic-Pharmacodynamic relationship, Metabolism and Plasma Protein Binding of the novel antitumor agent, 2-Methoxyestradiol (2ME2), following oral administration in patients with solid tumors.
… 2) 2ME2 will exhibit linear pharmacokinetics; 3) Plasma protein binding will be extensive and linear; 4) Sulfation will be the major metabolic pathway for 2ME2.This was a phase I dose escalation study. Twenty patients with refractory solid tumors were enrolled. 2ME2 was administered orally …
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Behavioral biomarkers for calf health
… passive transfer of immunity (hematocrit; total plasma protein; Immunoglobulins, IgG1 and IgM). Variables collected included: each calf’s first-meal suckling behaviors; automated activity behaviors, and measures of passive transfer of maternal antibodies (IgG1, Igm, hematocrit, and total plasma …
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The influence of diet on growth rate, thyroid hormone output, and thermoregulation in laboratory white rats
… effects of the consumption of diets varying in protein and calorie content was assessed using young male Sprague-Dawley rats. Food intake (FI), water intake (WI), body weight (BW), rectal temperature (Tre), oxygen consumption (VO{dollar}\sb2{dollar}), hematocrit (Hct), Hemoglobin (Hb), plasma …
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Influence of plasma proteins on setting characteristics of mineral trioxide aggregate like cement
… and γ-globulin, the three most abundant blood plasma proteins, both individually and in combination on the setting time, compressive strength and relative porosity of an MTA-like dental cement. The cement powder formulation was mixed with the liquid phase containing normal plasma protein …
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Plasma proteins and cardiac oedema
… of cardiac oedema is a depletion of the plasma proteins which results in a fall in the colloid osmotic pressure of the blood. This depletion is due principally to malnutrition, and it is suggested that cases of cardiac oedema should be given diets containing the maximum amount of protein …
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Impact of Ozonation on System Performance and Growth Characteristics of Hybrid Striped Bass (Morone chrysops (f) x Morone saxatilis (m)) Reared in Recirculating Aquaculture Systems
… (p 0.05). All parameters monitored except plasma protein and hematocrit values varied significantly (p>0.05) over time. Hemoglobin, plasma protein, and hematocrit values in fish under all rearing conditions were 10.2 ± 0.4 g/dL, 7.1± 0.6 g/dL, and 52.9 ± 1.9%, respectively. Final mean serum …
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A Nomogram for Valproic Acid and the Effect of Missed Doses
… Due to non-linear binding of VPA to plasma proteins, current dose titration schemes for VPA are empirical. The objectives of this research were to 1- study the effect of missed/delayed doses on steady state concentrations of VPA and 2-design a nomogram that can be used for dose …
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Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… as well as in vitro metabolism and plasma protein binding of MS-275, a novel histone deacetylase inhibitor, in patients with solid tumors and lymphomas. A validated LC/MS assay was developed to quantitate MS-275 in plasma, human liver microsomes and urine. The pharmacokinetic (PK) …
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Elucidating the Impact of Endogenous Proteins on Lipid Nanoparticle Organ-Targeting Outcomes
… delivery of LNPs results from interactions with plasma proteins involved in endogenous cholesterol transport. Building on this foundation, I characterized the targeting mechanism of selective organ targeting (SORT) nanoparticles, an LNP platform for tissue-specific RNA delivery to …
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Effects of hexachloronaphthalene on vitamin A metabolism in the rat
… effect of ingested hexachloronaphthalene on calf plasma protein was studied. The following conclusions were derived from the results of the experiments. 1. The metabolism of dietary hexachloronaphthalene resulted in an increased requirement for vitamin A in peripheral tissue. This effect was …
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Structure-activity relationships of PAI-1 inhibitors
… to PAI-1 with a low affinity, inhibit the serpin plasma protein antithrombin III, and/or fail to inhibit PAI-1 when vitronectin, a cofactor of PAI-1 is present. The synthesis of small-molecule inhibitors of PAI-1 that improve upon these properties has been the main goal of this research. Research …
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Ameliorating the toxic side-effects of cisplatin by systematically modulating its metabolism in human plasma with chemoprotective agents
… (SEC) coupled on-line to an inductively coupled plasma atomic emission spectrometer (ICP-AES), the effect of three chemoprotective agents − sodium thiosulfate (STS), N-acetyl-L-cysteine (NAC) and D-methionine − were investigated on the metabolism of the Pt-based anti-cancer drug cis-platin (CP) …
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