Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"plasma metabolites"”.
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Third Trimester Plasma Metabolites Associated with Gestational Diabetes: An Ancillary Analysis of the Healthy Beginnings Trial
… was conducted on third trimester (28 -35 weeks) plasma samples to observe differences associated with GDM.</p> <p><strong>Methods: </strong>Fifty samples taken from the Healthy Beginnings trial and their corresponding data were included in the study. Plasma samples were analyzed using UPLC-MS …
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Understanding the gender-based mechanism of mso in als mice: a metabolic characterization of the sod1-g93a mouse model
… of several urea cycle intermediates in the plasma compared to their wild-type counterparts. These plasma metabolites also show gender-specific differences in wild-type and SOD1 mice, supporting the idea that male and female mice have differences in metabolism. Plasma metabolites change with …
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Bayesian Balance Regression And Mediation Analysis For Microbiome Compositional Data
… gut microbiome in linking vegan diet to several plasma metabolites. Our analysis shows that vegan diet has strong direct effects and the compositional balance identified has a weak to moderate effect on these plasma metabolites, however, the mediation effects of gut microbiome on these …
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Development Of Isotags For Nmr Based Metabolite Profiling And Applications
… methods for detecting hundreds of quantifiable metabolites in biofluids using NMR spectroscopy or mass spectrometry. In this thesis we show improved sensitivity and resolution of NMR experiments imparted by 15N and 13C isotope tagging which enables the accurate analysis of plasma metabolites. To …
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Gluconeogenesis as a system : development of in vivo flux analysis of hepatic glucose production in Type 2 Diabetes
… 2H]-glycerol and mass spectrometry analysis of plasma metabolites. Using this methodology we observe physiologic changes in liver cell lines and primary hepatocyte cultures in the presence of hormones insulin/glucagon and in response to gluconeogenic precursor availability. We put forth the …
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The effects of oestradiol administration on energy metabolism during prolonged exercise in amenorrheic athletes
… a vein in the antecubital space and analysed for metabolites and hormones. Pre and post exercise muscle biopsies were taken in two subjects and were analysed for glycogen and lactate. Results from this study suggest that moderate elevation of semm oestradiol concentrations in amenorrheic athletes …
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The effect of exercise on the utilization of dietary energy by the laboratory rat
… liver glycogen levels, and concentrations of plasma metabolites (glucose, free fatty acids and triglycerides) during exercise. It is concluded that interactions between diet, exercise and metabolic adaptation to physical training can markedly affect the overall energy balance.
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"Interrogating the genomic and metabolomic landscape of pseudohypoxic phaeochromocytoma and paraganglioma syndromes"
… disease throughout the life course with imaging/plasma metanephrines and histopathological scoring systems has limitations[4, 5]. The discovery of metabolic rewiring of SDHx deficiency at the tumour level holds promise as a non-invasive disease biomarker. Endothelial PAS domain protein 1 (EPAS1 …
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Further elucidating the effects of ruminal and hindgut acidosis on the ruminant animal
… time, or their interaction on mesenteric plasma sucralose concentration. In cecal tissue, TEER tended (P = 0.09) to be lesser, indicating increase permeability in HGA ewes than CON ewes. In contrast, TEER was not different (P ≥ 0.83) in ileal or colonic tissues between treatments. A cecal …
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Common 'Inborn Errors' of Metabolism in the General Population
… or deficiency of circulating molecules (‘metabolites’) caused by rare genetic mutations. Previous studies have identified select examples where common variants at genes known to cause rare Mendelian diseases, including IEMs (e.g. LPL, DBH, PPM1K), are linked to phenotypic consequences in …
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The effects of novel and synthetic estrogens on liver health and microbiome crosstalk
… its effects on liver transcriptome and plasma metabolites have yet to be determined. We use several genomics and postgenomics technologies to characterize the effects of various estrogens on the health of the liver. Additionally we tested the effects of PaPE-1 on two different mouse …
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Energy and protein nutrition of ewes in late pregnancy
Feeding of the pregnant ewe affects its weight and condition and subsequently the ability to supply the lambs with adequate nutrition. Supplementing is commonly used to secure adequate birth weight and growth rate but for efficient use the condition of the ewes as well as total composition of the …
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The application of metabolomics in human health and disease
… that many of the amino acids were lowered in plasma post-exercise but the clearest impact of endurance exercise observed was on fatty acid metabolism with respect to formation of medium chain unsaturated and partially oxidised fatty acids and conjugates of fatty acids with carnitines, which …
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Stopover behavior and refueling physiology in relation to migration distance in Wilson's Warblers (Wilsonia Pusilla)
… and relative refueling rate was measured using plasma metabolite analysis. Compared to short-distance migrant individuals, longer-distance migrants passed through later during spring migration, had shorter minimum lengths of stay, larger fuel stores and a higher rate of refueling. During autumn, …
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Inflamatory status and leukocyte function during the peripartum period and subsequent effects on reproduction and lactational performance in dairy cattle
… of disease outcomes and monitoring blood metabolites can be useful in the identification of at-risk animals prior to the exhibition of clinical symptoms, possibly leading to a favorable outcome and reduction of animals involuntarily exiting the herd. In the first study, the association of …