Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"plasma membrane protein"”.
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Single Molecule-Based Computer Vision Analysis of Cortical Actin-Plasma Membrane Protein Interplay
The file named "NGO-PRIMARY-2025.pdf" is the primary dissertation file. The file named "1745621082149-Supplementary Video.zip" is a zipped file folder that contains 10 movie files (MP4 format), and a description of each video is included in Appendix B of the primary file (pages 148-149).
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TMEM27: A Cleaved and Shed Plasma Membrane Protein That Stimulates Pancreatic Beta Cell Proliferation
… the identification of a gene encoding transmembrane protein 27 (TMEM27) in pancreatic β cells. Expression of Tmem27 is reduced in Tcf1-/- mice, which exhibit defects in proliferation, and is increased in islets of ob/ob, db/db and aP2- Srebp-1c transgenic mice with marked hypertrophy of the …
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Influence of the cell wall on the organisation and dynamics of intracellular components in Arabidopsis Thaliana
… cell imaging of fluorescently labelled marker proteins to quantify the organisation and dynamics of the actin cytoskeleton and to determine if and how it was affected when the connection between the cell wall and plasma membrane was disturbed. Two image analysis techniques were developed to …
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Regulation of in vivo excitatory/inhibitory balance by the cystine/glutamate exchanger system xc-
… level – or with alterations in redox balance or plasma membrane protein expression levels, was also investigated. Overall, our data demonstrate that neuronal excitability in SLC7A11sut/sut mice provoked by chemoconvulsant challenge deviates from that of SLC7A11+/+ littermates in a complex manner …
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Elucidation of a Macrophage Cell Surface Receptor With Specificity for Exogenous Aromatic Hapten-Protein Antigens and Effects on Antigen Uptake and Processing
… the existence of an aromatic hapten-binding plasma membrane protein on macrophage cells with specificity for fluorescein. Moreover, the models proposed in this thesis have helped the further elucidation of the finer principles that dictate exogenous antigen processing and presentation in …
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THE ROLE OF HEPATOCYTE ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) AND APOLIPOPROTEIN M (APOM) IN HIGH DENSITY LIPOPROTEIN (HDL) METABOLISM
… cassette transporter A1 (ABCA1) and apolipoprotein M (apoM) both have been shown to influence high density lipoprotein (HDL) metabolism. Hepatic ABCA1, a plasma membrane protein, functions to transport free cholesterol (FC) and phospholipids across the plasma membrane to apolipoproteins, …
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TUMOR-PROMOTING FUNCTION AND MOLECULAR REGULATION OF TSPAN8 IN LIVER CANCER
TSPAN8 is an integral plasma membrane protein that belongs to the tetraspanin superfamily. In this study, we found that TSPAN8 is highly expressed in cholangiocytes but absent in hepatocytes in the healthy liver. Remarkably, its expression is robustly switched on in transformed hepatocytes in two …
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An investigation of the role of the Drosophila gene jim lovell in endopolyploid growth
… functions. I have shown that Lov is a nucleolar protein and that decreasing Lov levels can partially suppress the effects of dMyc on endopolyploid growth. I have also established that Lov interacts with another BTB/POZ domain protein called Ribbon (Rib) in controlling endopolyploid growth. Lov …
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[GAR⁺] : a novel type of prion involved in glucose signaling and environmental sensing in S. cerevisiae
Several well-characterized fungal proteins act as prions, proteins capable of multiple conformations, each with different activities, at least one of which is selfpropagating. We report a protein-based heritable element that confers resistance to glucosamine, [GAR⁺]. Genetically it resembles other …
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Regulation Of Apoptotic Alkalinization Through Phosphorylation Of Sodium Hydrogen Exchanger Via P38 Mitogen Activated Protein Kinase
… a rise in intracellular pH activated apoptotic proteins leading to cytochrome C release. This "apoptotic alkalinization" occurred upon activation of the plasma membrane protein, sodium hydrogen exchanger-1 (NHE1), whose activity is regulated by the stress kinase p38 MAPK. In previous studies, …
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Hormone-induced expression of the epithelial sodium channel in human airway cells
… the role of serum / glucocorticoid-inducible protein kinase 1 (SGK1) and protein kinase A (PKA) in the responses of hormone-stimulated H441 human airway cells. Dexamethasone, a synthetic glucocorticoid hormone, is thought to evoke expression of the gene encoding SGK1 and, to become …
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Hormonal regulation of long chain fatty uptake by adipocytes and studies of FATP gene family
… Type II diabetes. Transport of LCFA across the plasma membrane is facilitated by FATP, a plasma membrane protein that increases LCFA uptake when expressed in cultured mammalian cells (Schaffer and Lodish, 1994). We report the identification of family of evolutionarily conserved FATPs. In …
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Development and application of a high throughput cell based assay to identify apoptosis inducing proteins, and functional characterization of the candidate Vacuole Membrane Protein 1 (Vmp1)
… and functionally characterize novel human proteins that dominantly induce apoptosis upon overexpression. To achieve this, a cell-based high throughput assay was developed. The assay is based on the detection of activated caspase-3 in cells overexpressing proteins tagged C- and N-terminally …
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Structure and Function of Proteins Involved in Regulated Secretion: Synaptotagmins and Complexin
… tightly regulated process. There are a number of proteins required for membrane fusion to occur, and then there are regulatory proteins that allow membrane fusion to proceed at incredible speed with the precise timing necessary for complex functions such as sight, motor control, and conscious …
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Molecular characterisation of the <i>Rhynchosporium commune</i> interaction with barley
… Rc07_03591 and Rc07_02334 and a LysM containing protein (RcLysM3) were identified using a proteomic analysis of infected plant apoplast.<br/><br/>Further apoplastic analysis revealed some of the most abundant proteins that are present in R. commune’s infection toolkit. Cell wall degrading enzymes …
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Multifunctional bioreducible nanoparticles for gene therapy
… effect on AON transfection. We discovered that plasma membrane protein thiols played a key role in the observed enhancement of DNA transfection. </p> <p>We then explored the possibility of introducing targeting moiety (hyaluronic acid, HA) into the design and formulation of the bioreducible …
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Glucose metabolism in the outer segments of photoreceptor cells : its involvement in the phototransduction process
… approximately 2 % of the total rod outer segment protein and over 11 % of the plasma membrane protein. It has been purified by affinity chromatography on a NAD +-agarose column and shown to associate reversibly and electrostatically with a specific protein in the rod outer segment plasma membrane. …
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Discovery and functional analyses of new components of the apical complex and the pellicle of Toxoplasma gondii
The pellicle of the apicomplexan parasite Toxoplasma gondii is a shared structure among the supergroup Alveolata, which consists of a patchwork of flattened vesicles underneath the plasma membrane. The apical complex, from which the phylum obtains its name, is the defining feature of apicomplexans. …
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Investigating the mechanisms of BK Polyomavirus egress and virus-host interactions.
… small viral genome and paucity of viral proteins produced by BKPyV suggests a significant reliance on the host for viral life cycle progression. However, the lack of effective antiviral treatments indicates an incomplete understanding of such virus-host interactions. Therefore, this …
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Investigating TLR-4 signalling in response to protein ligands
… receptor (TIR) domains. The adaptor protein Myeloid differentiation primary response gene 88 (MyD88)-adaptor-like (Mal)/TIR domain-containing adaptor protein (TIRAP) then binds to the TIR domains of TLR-4 and acts as a bridge for MyD88 which goes on to form the myddosome, a large …
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