Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"plasma membrane expression"”.
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Cellular mechanisms that modulate kainate receptor trafficking and assembly
… non-cytoplasmic determinants that modulate KAR expression at the plasma membrane have been recently characterized. The intracellular trafficking determinants are presumed to bind to chaperone proteins, but these proteins have not been identified for any KAR subunit. Here we identified two …
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Profiling the Serotonin2 Receptor System Functional Capacity: Towards Identification of a Cocaine Use Disorder Biosignature
… a decrease in potency as a result of reduced plasma membrane expression from altered localization through the secretory and recycling pathway. We also demonstrate in vivo, that overexpressing the human Ser23 5-HT2CR in the medial prefrontal cortex, a key region implicated in relapse-like …
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Somatostatin Receptor 2 Regulation By C-Terminal Motifs and Pdz Domain Proteins
… the pathway through which sst2 recycles to the plasma membrane. We also determined that the expression of SHANK3, a PDZ domain containing protein, could alter the plasma membrane expression of sst2 indicating an important role in sst2 regulation. Overall, our results indicate that sst2 …
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The expression of potential molecular candidates for chloride ion channels in primary human granulocytes and granulocytic cell lines
… and western blot analysis to characterise the expression of hANO1, hBest1 and hCLCA1 as potential chloride ion channels in granulocytes and granulocytic cell lines. Systematic review was performed to identify whether chloride ion channels are up-regulated in COPD and asthma. RESULTS: RT-PCR …
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Molecular Interactions and Physiological Function of the Voltage-Dependent Calcium Channel Gamma6 Subunit
… Furthermore, I describe the use of cell surface membrane protein biotinylation, purification, and quantitative western blot to demonstrate that the functional effect gamma6 confers upon Cav3.1 current is not due to a change in the plasma membrane expression of Cav3.1. In Chapter III, I describe …
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Molecular basis of TAPBPR-mediated peptide editing on MHC class I molecules
… surface of cells. By examining the artefactual expression of TAPBPR at the cell surface upon over-expression, I developed two novel cellular assays which allowed me to explore the function of TAPBPR as a peptide exchange catalyst on plasma membrane-expressed MHC class I molecules. I showed that, …