Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"plasma membrane calcium ATPase"”.
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Structural studies on the plant plasma membrane calcium-ATPase
The plasma membrane Ca$\sp{2+}$-ATPase is a ubiquitous membrane protein that mediates the active transport of calcium out of the cytoplasm into the cell exterior. In plant cells it is believed to play a major regulatory role in signal transduction by helping to maintain a large gradient of calcium …
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Plasma membrane calcium ATPase 4 (PMCA4) and inflammation of the aortic endothelium
… vascular diseases, including atherosclerosis. Plasma Membrane Calcium ATPase 4 (PMCA4) belongs to a family of transmembrane ion transporters that extrude calcium from the cytosol to the extracellular environment (Strehler, 2015). They are the only high-affinity Ca2+ extrusion system in …
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Role of the Plasma Membrane Calcium ATPase as a Negative Regulator of Angiogenesis
… would be beneficial. One possibility is the plasma membrane calcium ATPases (PMCAs). These high affinity calcium extrusion pumps have been shown to interact with calcineurin in mammalian cells and cardiomyocytes and down-regulate the calcineurin/NFAT pathway. This is hypothesised to be due to …
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A NOVEL SELECTIVE INHIBITOR FOR PLASMA MEMBRANE CALCIUM ATPase 4 IMPROVES VEGF-MEDIATED ANGIOGENESIS
… has recently shown a novel role for the plasma membrane calcium ATPase 4 (PMCA4) protein as a negative regulator of VEGF-induced angiogenesis via interaction with calcineurin. The recent identification of aurintricarboxylic acid (ATA) as a selective inhibitor of PMCA4 prompted us to …
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Investigating the expression of plasma membrane calcium ATPase (PMCA) in patient-derived glioblastoma cultures
… challenges, this thesis explores the role of Plasma Membrane Calcium ATPases (PMCAs) in the pathology of glioblastoma, with a specific focus on isoforms PMCA1, PMCA2, and PMCA4. Patient-derived glioblastoma cultures and biopsy samples were employed to investigate PMCA expression patterns at …
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Regulation of VEGF-activated signalling by the plasma membrane calcium ATPase 4 in endothelial cells
… has previously reported a negative role for the Plasma Membrane Calcium ATPase 4 (PMCA4) protein in endothelial cells, acting via inhibition of the pro-angiogenic calcineurin/NFAT signalling pathway. However, we hypothesise that other intracellular pathways might be regulated by PMCA4 in …
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Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
… PAH and are known to induce endothelial injury. Calcium dysregulation contributes to apoptotic signalling, suggesting that calcium transporters like Plasma Membrane Calcium ATPase 4 (PMCA4) may play an important regulatory role. PMCA4, encoded by ATP2B4, maintains calcium homeostasis and …
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Molecular and cellular mechanisms implicated in the regulation of cellular PMCA expression during pulmonary arterial hypertension
… pathway driven by TNF-α has been shown to be calcium dependent, and several studies have confirmed the increased concentration of cytosolic calcium as a key molecular influence in cell mediated vasoconstriction and proliferation. This necessitates the need for determination of the activity of …
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Targeting the calcium ATPase to the endoplasmic reticulum
The sarco/endoplasmic reticulum calcium ATPase (SERCA) pumps calcium from the<br/>cytoplasm into the lumen of the endoplasmic or sarcoplasmic reticulum (ER/SR), removing<br/>excess Ca2+ from the cytoplasm and replenishing ER/SR Ca2+ stores. SERCA is located in<br/>both the ER and the ER-Golgi …
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PMCA as a regulator of calcium/calmodulin-dependent signal transduction pathways
Plasma membrane calcium/calmodulin-dependent calcium ATPases (PMCAs) are high affinity calcium pumps regulating many calcium-dependent processes and advances in its characterisation have discovered that it may play a novel role in signal transduction pathways. It was the aim of this work to further …
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Die Plasmamembran-Kalzium-ATPase im Myokard
Die Plasmamembran Kalzium-ATPase (PMCA) ist ein in den meisten eukaryontischen Zellen exprimiertes Enzym. Sie katalysiert den Transport von Kalziumionen aus der Zelle und besitzt gegenüber Kalzium eine hohe Affinität jedoch geringe Transportkapazität. Trotz der guten biochemischen Charakterisierung …