Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"plasma clearance"”.
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Engineering antibodies for improved targeting of solid tumors
… including antibody size, binding affinity, plasma clearance rate, and cellular catabolism. Here we probe each of these parameters and its effect on tumor penetration using a combination of computational modeling and protein engineering. In the first part of this thesis, we characterize the …
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An Investigation into the Use of Dried Blood Spot Analysis in Pharmacokinetic Studies
… to estimate primary pharmacokinetic parameters, clearance (mean, 0.18 l/h/kg) and volume of distribution (mean, 1.33 l/kg). The whole blood derived mean estimates were similar to previous plasma clearance and volume estimates of 0.14 l/h/kg and 1.91 l/kg, respectively reported in neonates (n=7). …
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Antibody engineering for tumor immunotherapy
… of diffusion, binding, degradation, and plasma clearance in tumor microspheroids.
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LOCO-REGIONALLY TARGETING INTERLEUKIN-13 RECEPTOR ALPHA-2 AND MAXIMIZING THERAPEUTIC ACCESS TO GLIOBLASTOMAS USING BIOMARKER DIRECTED ALPHA PARTICLES
… small size which results in relatively brisk plasma clearance. My dissertation includes and summarizes reports where we evaluated the feasibility of delivering a loco-regional cy to IL13RA2 expressing GBMs using Pep-1L and where we addressed potential challenges due to ineffective therapeutic …
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P-glycoprotein and membrane permeability as determinants of xenobiotic bioavailability and bioaccumulation
… preexposure (0.1mg/day/kg body weight) increased plasma clearance (17%) and reduced tissue concentrations of 3H-tetracycline equivalents (parent and metabolites) for a single intra-aortic administration of 3H-tetracycline (8.31µg/kg body weight) in catfish. A 23% increase in the immunoreactive …
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Role of Lipoprotein Lipase in Lipid Metabolism: The Effects of Exercise and Diet
Fatty acids derived from plasma triglycerides (TG) represent an important source of energy for skeletal and cardiac muscles and for storage in adipose tissue. In order to use plasma TG, fatty acids (FA) must be released from the glycerol backbone before uptake by tissues. Lipoprotein lipase (LPL) …
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Evaluation of iohexol clearance to estimate glomerular filtration rate in normal horses
… such as endogenous or exogenous renal creatinine clearance. These techniques can be time consuming, dangerous to perform on fractious patients, require trained personnel and are subject to errors most often associated with improper or incomplete urine collection. Recently, tests using iohexol, a …
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Engineering developable miniprotein ligand scaffolds
… such as their modularity, tissue penetration, plasma clearance, and cost-effective manufacturing. Yet, engineering miniproteins as scaffolds is complex due to their small size, which poses a challenge in integrating novel functionality while also maintaining biophysical integrity. The challenge …
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Evaluation of ceftiofur sodium as a chemotherapeutic agent in grass carp (Ctenopharyngodon idella)
… weight. Serial blood samples were obtained and plasma samples were analyzed by high performance liquid chromatography for ceftiofur (as measured its metabolite, desfuroylceftiofur (DFC) and DFC-related metabolite concentrations). Disposition pharmacokinetic data were best described by a two …
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A Pharmacokinetics and Pharmacodynamics (PK/PD) Guided Approach to Lead Optimization of Nitrofuranylamide Anti-Tuberculosis Agents
… compound, Lee 562, exhibited a high systemic clearance, short terminal half-life, and low oral bioavailability of 15.9%. These observations were further supported by the poor metabolic stability of Lee 562. Thus, two second generation follow-up compounds, Lee 878 and Lee 952 were tested that …