Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"plasma cell"”.
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Nanomanipulator perturbation of dust crystals in a GEC rf plasma cell.
… of observable matter is composed of complex plasma. Even with its prevalence, the interactions between the plasma's constituents are not fully understood. In many cases, clouds of dust grains from and can even display organized, crystal-like, structures. Understanding the interparticle forces …
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Monogenetic Immune Dysregulation Syndromes and their Effect on the Plasma Cell Compartment
… diseases, these interactions are altered. Plasma cells (PC) and their B cell progenitors, that play a key role in maintaining humoral and cellular memory, are impaired within these patients. We characterised different features of plasma cells in immune dysregulated individuals via flow …
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Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
… regarding their effects on anti-tumour B and plasma cell responses, which are now regarded as important components of the adaptive immune response to cancer. Additionally, the utility of ICB therapies is limited by the immune-related adverse events (IrAEs) they induce – toxic autoimmune …
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MULTIPLE MYELOMA PLASMA CELL PROFILING: INTEGRATED SINGLE-CELL RNA AND VDJ SEQUENCING APPROACHES UNCOVER NOVEL CLINICAL INSIGHTS
… caratterizzata dalla proliferazione di plasmacellule (PCs) nel midollo osseo (BM) che secernono anticorpi. È preceduto da stadi asintomatici definiti come Gammapatia Monoclonale di Significato Indeterminato (MGUS) o Mieloma Multiplo Smouldering (SMM). Il MM presenta architetture clonali …
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Combination of Dasatinib and Dexamethasone targets the myeloma plasma cell through its interaction with the bone marrow microenvironment
… eventually relapse with progressive disease. Cell adhesion mediated drug resistance and a permissive bone marrow microenvironment facilitates myeloma cell survival. Upto 90% of myeloma patients present with bone disease of varying degrees, which is a result of enhanced osteoclastic activity …
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Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… characteristic of SLE, including peripheral plasma cell accumulation, anti-dsDNA antibodies, and GN. Lyn is a Src-family tyrosine kinase that, in general, inhibits B cell and myeloid cell activity. Loss of Lyn results in cellular hyperactivity associated with autoantibody production. Bruton’s …
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The interactions of tolerogenic dendritic cells, induced regulatory T cells and antigen-specific IgG1-secreting plasma cells in asthma
… IL-10-differentiated dendritic cells (DC) (DC10) leads to progressive and long-lasting full-spectrum asthma tolerance. However, little has been done in investigating a role for antigen-specific B cells in DC10-induced tolerance. In this study, we characterized the surface markers …
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Pathogenic and Protective Potential of B Cell Dysregulation in Systemic Lupus Erythematosus
… of tolerance to nuclear antigens. Hyperactive B cells are present in SLE patients and murine models of lupus, many of which have defects in inhibitors of B cell receptor (BCR) signaling or plasma cell differentiation. Autoantibodies against a wide range of self antigens contribute to the …
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Mapping the spatial organisation of B cells and immune signalling in TNBC to characterise response to immunotherapy
In recent years, B cells and tertiary lymphoid structures (TLS) have emerged as key predictors of immunotherapy response across multiple cancers. B cells exist in various states of spatial organisation within the tumour microenvironment (TME), which likely support many of their functional roles. …
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INVESTIGATING IMMUNE SYSTEM REGULATION THROUGH CROSS-DISEASE GENETIC ANALYSIS AND B CELL FATE DECISIONS
… altering the same immune-mediated pathways in T cells. I found evidence that showed the causal role of 46 genes in predisposing to the three disease groups; eight of these genes are already targeted by treatments in autoimmunity and could be exploited for drug repurposing. Supporting preclinical …
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Investigating the role of the post-transcriptional regulator protein ZFP36L1 in B-cell functions
… its role in post-transcriptional regulation in B-cell development is extremely limited. The primary aim of this project was to investigate role of ZFP36L1 in regulating B-cell development, in particular late B-cell development (plasma-cell differentiation). BCL-1 cells (provide a model system to …
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Biogenesis of Membrane-Bound and Secreted Immunoglobulins
… (Igs). The subpopulation of lymphoid cells that synthesize these molecules are so defined as members of the B lineage; the end-stage cell type of this lineage is the plasma cell. The acceptance, over the past thirty years, of myeloma proteins as normal products of plasma cells in …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… determine the role of Fyn kinase and ADAM10 in B cell biology. A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple …
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Signals for B cell activation in antibody response
… are the sites where V-gene hypermutation and B cell selection are taking place. Testing specificity and affinity of GC B cell receptor by interaction with antigen on follicular dendritic cells (FDCs) may be an important selection process to select high affinity B cell clone. As antigen on FDC is …
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Understanding the function of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis
… lack of ICOS costimulation led to diminished B cell and plasma cell expansion, whereas the number of CD4+ T helper cells was increased. Collectively, these results indicate that lymphocyte costimulation through the ICOS/ICOSL pathway is a vital component of the adaptive immune response to AChR …
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Probing the sensitivity of autoantibody production to B cell depletion by Rituximab
… CD20 antigen, causes profound depletion of all B cells. When used in patients with autoimmune disease, IgG autoantibody titres often fall whilst serum IgG anti-tetanus toxoid antibody titres are unaffected. Antibodies of both these antibody specificities have features associated with production by …
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Characterization of downstream target genes regulated by ABF-1 in different states of B cell development
… nodes, and appendix, as well as transformed B cells lines infected with Epstein-Barr virus. This study investigates the role of ABF-1 in regulating downstream target genes in the human mature B cell line RAJI, as well as the plasma cell line, ARH-77. Quantitative real-time polymerase chain …
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The VH repertoire and clonal diversification of B cells in myositis and vasculitis
… to a variety of self antigens but the precise cellular and molecular mechanisms resulting in pathology are largely unresolved. In some instances T cell mediated reactions are thought to be the main contributors to disease mechanisms but it is becoming increasingly evident that B cells, and …
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Investigating the utility of blood borne oncological biomarkers in solid tumours: glioma and melanoma
… research work explored the potential utility of plasma cell-free DNA, circulating tumour DNA, cell-free messenger RNA, and bloodborne tumour related proteins as disease biomarkers in patients with glioma and metastatic melanoma. The in vivo research work employed an animal model to study micro …
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