Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"plaque vulnerability"”.
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Classification of atherosclerotic plaque vulnerability by mechano-radiomics
… resonance (MR) images can help evaluate carotid plaque vulnerability better than conventional MR methods. Hemodynamic forces have long been associated with the destabilization of developed plaques near regions of complex blood flow e.g., the carotid bifurcation, which results in high wall shear …
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Multimodal Imaging of Inflammation at the Neurovascular Interface in Cerebrovascular Disease
A carotid atherosclerotic plaque represents a nidus of inflammation mere centimetres below the blood-brain barrier. This inflammation, along with associated regions of microcalcification, are histopathological features of atheroma at risk of rupture (so-called “vulnerable plaques”) that trigger …
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hs-CRP level represents the disease burden and the age but not vulnerability of coronary atherosclerosis
… presented hs-CRP level was associated with plaque vulnerability but most studies were performed by assessing focal target plaque but not whole plaques from a coronary tree. METHODS: To evaluate of the relationship of plasma hs-CRP level and volumetric plaque composition of the coronary …
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Impact of Percutaneous Transluminal Intervention on Vascular Hypoxia and the Role of Micro-calcifications on Atherosclerotic Plaque Rupture
… which evolves into a fibroatheroma, a lipid-rich plaque covered by a fibrous cap. Many of these plaques are considered as vulnerable, as they grow to occlude the luminal section of the artery (chronically stenotic) or become mechanically unstable with a higher chance of rupturing (rupture-prone). …
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Identification of potential clinical indicators of carotid plaque disruption using patient specific finite element modelling
… wall may provide an indicator of atherosclerotic plaque disruption. Many studies have used patient specific finite element models to estimate the stress environment in atherosclerotic plaques, attempting to correlate the magnitude of stress to plaque vulnerability. This thesis investigates the …
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Elastography using optical coherence tomography : development and validation of a novel technique
… have characterized rupture-prone atherosclerotic plaques by the presence of a large lipid-rich core covered by a thin fibrous cap. Studies employing finite element analysis (FEA) based on ex vivo plaque geometry have found that most plaques rupture at sites of high circumferential stress, thus …
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Model parameter estimation of atherosclerotic plaque mechanical properties : calculus-based and heuristic algorithms
… pathways. This thesis focuses on studying plaque biomechanics because (i) there is a dearth of data on the mechanical behavior of soft arterial tissue yet (ii) it is the biomechanics that is able to provide invaluable insight into patient-specific disease evolution and plaque vulnerability. …
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The Relationship Between Volumetric Plaque Components and Classical Cardiovascular Risk Factors and the Metabolic Syndrome
… The aim of this study was to analyze volumetric plaque composition of the coronary arterial tree according to the classical cardiovascular risk factors and metabolic syndrome (MS) by using virtual histology-intravascular ultrasound (VH-IVUS). Background: It remains unclear how the cardiovascular …
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Development of a Vascularized Carotid Artery Plaque Phantom for the Investigation of Novel Ultrasound-Based Technologies
… detection and diagnosis of atherosclerotic plaques, and for quantitative measures of disease progression. Vulnerable plaque lesions are thought to be responsible for the majority of cardiovascular events, characterized by a large lipid core, a thin fibrous cap, and neovascularization – …
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Development of novel antibody-based diagnostics for the early and rapid detection of cardiac markers
… of MPO have been reported in atherosclerotic plaques and accumulating evidence indicates that MPO may have a causative role in plaque vulnerability. It has been suggested that these markers may even be complementary in the assessment of patient cardiac risk. As a marker of disease activity and …
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Identifying Vulnerable Plaques with Acoustic Radiation Force Impulse Imaging
<p>The rupture of arterial plaques is the most common cause of ischemic complications including stroke, the fourth leading cause of death and number one cause of long term disability in the United States. Unfortunately, because conventional diagnostic tools fail to identify plaques that confer the …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… and subsequent macrophage infiltration into plaques. DKO mice received either the MR antagonist eplerenone (200mg/kg/day) or vehicle in normal chow diet from 2 months of age for 12 weeks. Eplerenone significantly decreased atherosclerotic burden in brachiocephalic arteries of DKO mice, an …
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The assessment of biomechanical modelling and PET/MR imaging in coronary atherosclerosis
… by the rupture of the coronary atherosclerotic plaques. Angiography-defined luminal stenosis is the only validated criterion for clinical decision making. However, post-mortem studies showed that only 14% of myocardial infarctions (MIs) were caused by plaques with >70% stenosis. Plaque …
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Imaging microcalcium in thoracic aortic disease
… of atheromatous disease that is associated with plaque vulnerability and the culprit lesions underlying atherothrombotic events. In a post-hoc observational cohort study, thoracic aortic 18F-sodium fluoride activity was quantified in 461 patients with stable cardiovascular disease undergoing …