Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"plaque formation"”.
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Modulation of Alzheimer’s Disease Pathology by Collagen-Induced Rheumatoid Arthritis in APP/PS1 Mice
… arthritis (CIA) on cognitive function, amyloid plaque formation, microglial activation, and cerebrovascular pathology in the cortex and hippocampus of the double transgenic APP/PS1 mouse model for AD. Wild-type or APP/PS1 mice that received type II collagen (CII) in complete Freund’s adjuvant …
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Smooth Muscle Cell Stress Response: Essential in Atherosclerotic Pathogenesis
… of smooth muscle cells (SMCs) in atherosclerotic plaque formation. SMCs undergo complex phenotypic modulation characterized by de-differentiation of SMCs and heterogeneously increased expression of markers for macrophages, fibroblasts, chondrocytes, and mesenchymal stem cells as plaques form. …
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Viscoelastic two-dimensional modeling of cell deformation due to shear stress on apical focal adhesion, with experimental design considerations
… gene transcription in the cell nucleus to conformational changes in membrane channel proteins that lead to increased or decreased ion permeability, external stresses imposed on the cell can significantly affect cellular actions through a process known as "mechanotransduction." While such …
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IL-25 and B cells in atherosclerosis
… of the body which is mainly characterized by the formation of lipid rich plaques within the arterial tissue. It is the most common cause of cardiovascular disease leading to clinical manifestations of coronary artery and cerebrovascular disease. Immune responses targeting modified low density …
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Role Of Substrate Stiffness In Driving Atherogenic Behavior In Macrophages.
… prominent immune cell type in atherosclerotic plaque due to its involvement in lipid clearance, apoptotic cell debris clearance and pro- or anti-inflammatory cytokine production. While the molecular mechanisms active in lesional macrophages have been extensively studied, the effect of age- and …
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Factors That Influence Mammalian Enteric Virus Infection
… multiple polioviruses are found within a single plaque even at low multiplicity of infection. I also showed that poliovirus stocks contain virion aggregates and that aggregates induce co-infection. Furthermore, I found that co-infection frequency was increased when polioviruses were heavily …
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Correlation Between Immediate Hypersensitivity and Gingivitis
Bacterial plaque has been implicated as the primary etiologie factor in inflammatory periodontal disease. The most direct evidence comes from such studies as those by Loe, Theilade, and Jensen, who examined the production of gingival inflammation in healthy adults who stopped toothbrushing and …
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MITOCHONDRIAL DNA COPY NUMBER AND AUTOPHAGY IN THE AGING BRAIN AND IN AN ALZHEIMER MOUSE MODEL
… but it is not known whether autophagosomal formation is overactive and/or degradation of autophagosomes is inhibited in AD. Although two-thirds of the 5 million Americans diagnosed with AD are women, without a clear mechanism. Since the role of gender and autophagy in AD is unclear, we …
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Factors That Influence Monocyte Differentiation and Hematopoietic Stem Cell Recruitment In Atherogenesis
… subsequent lipid uptake and accumulation causing plaque growth and atheroma formation. Hyperlipidemia and other risk factors for cardiovascular disease promote the conversion of LDL to ox-LDL, which causes insult to the vascular wall. One of the earliest events of atherogenesis is the adhesion of …
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Role of Sodium Arsenite in Atherogenesis
… showed an increasing trend in atherosclerotic plaque formation in as early as 5 weeks within the innominate arteries. Most remarkable was the evidence that environmentally relevant concentrations of As(III) resulted in significant increase in plaque formation. Initiation of atherosclerosis …
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Role of Sodium Arsenite in Atherogenesis
… showed an increasing trend in atherosclerotic plaque formation in as early as 5 weeks within the innominate arteries. Most remarkable was the evidence that environmentally relevant concentrations of As(III) resulted in significant increase in plaque formation. Initiation of atherosclerosis …
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Toxicological and Pharmacological Studies on Amide Derivatives of 5-Methoxymethyl-2'-Deoxycytidine
… cells and VERO cells was determined using the plaque reduction assay. The potency of MMdCyd and amide derivatives was higher in A549 cells as compared to VERO cells. Butanoyl-MMdCyd (But-MMdCyd) was the most potent compound in both cell lines. Concentrations of MMdCyd and But-MMdCyd required to …
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Serotonergic Signaling Pathways that Suppress Amyloid Beta in Mouse Models of AD
… as their brains become riddled with beta amyloid plaques. Alzheimer's is especially terrifying because there currently are no effective treatments for slowing or stopping the disease. However, recent research has shown that plaque formation is correlated to concentrations of amyloid beta. This …
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Controls on arsenic mobility in contaminated wetland and riverbed streams
… sediments. We investigated the extent of Fe plaque formation on Typha latifolia roots (cattail), and the mechanism of As sequestration in plaques and (near-root) rhizosphere sediment. The plaque was approximately 30 gm thick, with a strong correlation between As and Fe, as determined by XRF …
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Comparative histology and histochemistry of the vascular system in the White Plymouth Rock hen and the pit fowl hen
… differences in predisposition to atherosclerotic plaques and, (4) relate the incidence of plaques to anatomical and histochemical differences. The iliac tunica media of the pit fowl was found significantly thicker than that of the White Rock. The tunica adventitia of all iliac arteries having no …
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Mechanisms of Brain Region-Specific Amyloid-beta Deposition
… deposition of extracellular amyloid plaques principally comprised of the amyloid-β: Aβ) peptide. Using mouse models of cerebral Aβ deposition, we examined molecular, cellular and systems-level mechanisms that regulate brain region-specific Aβ accumulation and …
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Identification of Connexins in Facilitating Neuron-Satellite Glial Cell Signaling in Trigeminal Ganglia
… temporomandibular joint (TMJ). Importantly, the formation of gap junction plaques by Cx26 was observed between neurons and satellite glial cells. In other studies, a model of acute-sensitization was used to simulate the significant comorbitities between rhinosinusitus and migraine. In this model, …
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The Effects of Lowering Cholesterol on Vasodilation
… been found prior to any signs of atherosclerotic plaque formation in patients with a variety of risk factors for atherosclerosis. Elevated serum cholesterol has repeatedly been associated with endothelial dysfunction as demonstrated by impaired vasoreactivity to vasodilating stimuli.</p> <p>The …
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Mixed Dementia Induced by Right Common Carotid Artery Occlusion in an Alzheimer Mouse Model
… CCH would aggravate the behavioral changes and plaque formation in an AD transgenic (Tg) mouse model. Female Tg2576 (Tg+) mice (an AD model) and their littermates (Tg-) were subjected to permanent right common carotid artery occlusion (rCCAO). The Morris water maze and object recognition tests …
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RNA-binding proteins mediate anti-inflammatory regulation of vascular disease
… EIF2α phosphorylation, requisite for SG formation, was also induced by clotrimazole and oxLDL in these cells. Interestingly, VSMCs pre-treated with anti-inflammatory cytokine IL-19 followed by clotrimazole significantly reduced the formation of SGs and eIF2a phosphorylation, suggesting a …
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