Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"plant secondary metabolism"”.
-
Elucidation of gene clusters underlying withanolide biosynthesis in ashwagandha
… (ashwagandha) amongst other Solanaceae family plants, known for their anti-inflammatory, anti-cancer, and adaptogenic properties. However, the biosynthetic pathway to withanolides is largely unknown, preventing scale-up and hindering pharmaceutical applications. In this thesis, we report a …
-
Combinatorial biochemistry of triterpene saponins in plants
Plants are capable of synthesizing an overwhelming variety of secondary metabolites, many of which possess biological activities relevant for the pharmaceutical and chemical industries. Furthermore, there is an ever increasing demand for novel compounds, due to, among others, the growing drug …
-
Reprogramming alkaloid biosynthesis in Catharanthus roseus : synthetic biology in plants
The medicinal plant Madagascar periwinkle (Catharanthus roseus) produces over 130 monoterpene indole alkaloid (MIA) natural products. Many of these compounds have pharmaceutical value, such as the anticancer agents vinblastine and vincristine. Unnatural modifications can impart novel bioactivity to …
-
Functional analysis of selected DOF transcription factors in the model plant Arabidopsis thaliana
… (DOF) TFs from the genetic model plant Arabidopsis thaliana, namely OBP1, OBP2 and AtDOF4;2. These genes were selected due to severe growth phenotypes conferred upon their constitutive over-expression. To identify biological processes regulated by OBP1, OBP2 and AtDOF4;2 in detail …
-
Effects of several abiotic and biotic factors and plant hormones on growth, morophology, and camptothecin accumulation in Camptotheca acuminata seedlings
… biotic factor [acetylsalicylic acid (ASA)], and plant hormones [benzyl adenine (BA) and naphthalene acetic acid (NAA)] on growth, morphology, and secondary metabolite, camptothecin (CPT, an anti-cancer compound) accumulation in Camptotheca acuminata. Five experiments were conducted with C. …
-
Preliminary characterization of VmTPT2, a putative monoterpene indole alkaloid (MIA) transporter from Vinca minor L. (Apocynaceae)
… surface of medicinally important Apocynaceae plants, which led to the recent discovery and characterization of an ABC transporter (CrTPT2) that was shown to mobilize catharanthine from its site of biosynthesis in epidermal cells to the leaf surface of Catharanthus roseus. Bioinformatic …
-
Functional Characterization of Monoterpenoid Indole Alkaloid (MIA) Biosynthetic Genes in Catharanthus roseus
… for the low levels of dimeric MIAs found in the plants, the secretion of catharanthine to the leaf surface is shown to be part of plant defense mechanisms against fungal infection and insect herbivores. The transcriptomic databases of Catharanthus roseus and various MIA producing plants are …