Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"planar cell polarity"”.
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Hexagonal packing of Drosophila wing epithelial cells by the Planar Cell Polarity pathway
The mechanisms that order cellular packing geometry are critical for the functioning of many tissues, but are poorly understood. Here we investigate this problem in the developing wing of Drosophila. The surface of the wing is decorated by hexagonally packed hairs that are uniformly oriented …
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Uncovering Signalling Pathways Mediating Gastrointestinal Morphogenesis and Tumorigenesis
… development requires precisely coordinated intercellular communication via signalling pathways, mechanisms underlying intestinal morphogenesis remain unclear. The Hedgehog signalling pathway is critical for many aspects of gut development, however, its downstream transcriptional targets allowing …
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Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation
… changes to adopt complex shapes. Coordinated cell behaviors, including oriented cell divisions are crucial to the proper development of epithelia. How forces are transmitted across the developing embryo and how these forces along with genetic programs that are active at this time contribute to …
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Dact Family Molecules In Wnt Signaling In Mouse Development
… be integral in the embryonic patterning of multicellular animals, and are misregulated in multiple types of cancer. Wnt signaling includes multiple biochemical signaling pathways downstream of the Wnt family of secreted proteins and their receptors. Many, and possibly all, of these pathways …
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The Role of Daam1 In Kidney Development
… mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric tubules lined with hair-like sensory projections called cilia. Many diseases of the kidney are characterized by abnormal nephron morphology with current treatment aimed at symptom control. To …
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The Role of Daam1 In Kidney Development
… mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric tubules lined with hair-like sensory projections called cilia. Many diseases of the kidney are characterized by abnormal nephron morphology with current treatment aimed at symptom control. To …
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The Role of Pkd1 in Mouse Inner Ear Hair Cells
… transduction (MET) channel in inner ear hair cells based on PC-1 role of fluid flow sensing and calcium uptake into renal epithelial cells. However, two independent mouse lines with PC-1 mutations exhibit normal MET channel function despite hearing loss and ultra-structural abnormalities of …
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Daple Orients and Patterns Sensory Hair Bundles in the Inner Ear
<p>The planar orientation of mammalian cells necessitates the integration of diverse pathways. In the inner ear, at least two systems regulate the planar polarity of the hair bundle. The core planar cell polarity (PCP) proteins coordinate the orientations of hair cells across the epithelial plane. …
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Characterizing the Role of Spegless, a Novel Inner Nuclear Membrane Protein required for spermatogenesis and oogenesis in Drosophila melanogaster
… that plays a role in both tissue growth and planar cell polarity (PCP). How Fat regulates these cellular processes is not fully understood. A yeast two-hybrid screen previously identified proteins that can bind the cytoplasmic domain of Fat. Using genome-wide RNAi libraries of transgenic …
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Characterizing the Nuclear Function of the Cell Adhesion Molecule Fat and Chromatin Regulation by the Inner Nuclear Membrane Protein Speg
Tissue growth, pattern formation and cell metabolism are fundamental to animal development. Coordination of these aspects requires elegant signal transduction systems. In Drosophila, fat (ft) encodes an enormous atypical cadherin that is important for such coordination. Ft functions at the cell …
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Regulation of Zebrafish Gastrulation Movements by slb/wnt11
During zebrafish gastrulation, highly coordinated cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Recent studies have identified silberblick (slb/wnt11) as a key molecule that regulates gastrulation movement through a conserved pathway, which …
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Fgf4 and Wnt5a/Pcp Signaling Promote Limb Outgrowth by Polarizing Limb Mesenchyme
… of this study was to elucidate the molecular and cellular mechanisms whereby fibroblast growth factors (FGFs) mediate outgrowth of the limb. Specifically, we examined the epistatic relationship between FGF and Wnt/Planar cell polarity (PCP) signaling in establishing cell polarity as a mechanism …
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The genetic interactions of PKHD1 and ATMIN in autosomal recessive polycystic kidney disease (ARPKD)
… which encodes a ciliary protein associated with planar cell polarity. In mice, mutations in the transcription factor Atmin can present with an ARPKD-like phenotype with kidney disease similar to an early manifestation of ARPKD. Like the mouse gene Pkhd1, mutations in Atmin are associated with …
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Local Wnt11 Signalling and its role in coordinating cell behaviour in zebrafish embryos
Wnt11 is a key signalling molecule that regulates cell polarity/migration during vertebrate development and also promotes the invasive behaviour of adult cancer cells. It is therefore essential to understand the mechanisms by which Wnt11 signalling regulates cell behaviour. The process of …
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Investigating WNT signalling in the lung
… As a branch of non-canonical WNT signalling, the planar cell polarity (PCP) pathway has emerged as a key ciliary signalling mechanism. Recent studies have highlighted the involvement of core PCP proteins in both ARPKD pathology and lung development and homeostasis. The aim of the study was to …
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Regulation of Wnt signalling pathways by the Dishevelled DEP domain
… noncanonical signalling responses that control cell fates during animal development and tissue homeostasis. All Wnt signals are relayed by the hub protein Dishevelled (DVL). During canonical (β-catenin dependent) signalling, Dishevelled assembles signalosomes via dynamic head-to-tail …
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Wnt9b Signals Through Two Distinct Pathways to Regulate Progenitor Maintenance, Differentiation and Morphogenesis During Kidney Development
… the expansion of the existing tubule progenitor cells. The molecular mechanisms by which this balance is achieved are poorly understood. Previous studies suggested that Wnt/_-catenin signaling was necessary and sufficient to induce tubule formation. Further, it was hypothesized that the pathway …
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The Role of PRICKLE1 in the Regulation of Uterine Structure and Physiology
… implantation and pregnancy. The smooth muscle cells of the myometrial layer are organized into several sub-layers with longitudinal and circular orientations and help to facilitate uterine contractions and sperm transport. The specific cellular arrangement and orienertaion is crucial for the …
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A Phenotypic And Genetic Characterization Of The Cell Adhesion Molecules Echinoid And Friend-Of-Echinoid In The Directed Cell Movements Of Ommatidial Rotation During Drosophila Eye Development.
Correct development of multicellular organisms relies on the precise patterning of cells, which must respond to and interpret specific cues that instruct the cells to differentiate and often undergo directed cell movements and rearrangements to give rise to functional tissues and organs. …