Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"placode"”.
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The Role of Pax6 in Lens Placode Formation
THE ROLE OF PAX6 IN LENS PLACODE FORMATION by Jie Huang Washington University in St. Louis, 2010 Professor David Beeebe, Chairperson Although placodes are ubiquitous precursors of tissue invagination, the mechanism of placode formation and its importance for invagination are unclear. We tested the …
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The Role of FGFR4 in Trigeminal Placode Cell Development
… embryos, the ophthalmic trigeminal (opV) placode contributes sensory neurons to the trigeminal ganglion during development of the peripheral nervous system. FGFR4 is expressed transiently in the trigeminal placode as cells undergo an epithelial-mesenchymal transition and begin to migrate …
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The Role of Wnt Signaling in Development of the Ophthalmic Trigeminal Placode.
<p>Cranial placodes are ectodermal regions that contribute extensively to the vertebrate peripheral nervous system. The development of the ophthalmic trigeminal (opV) placode, which gives rise only to sensory neurons of the ophthalmic lobe of the trigeminal ganglion, is a well-studied model of …
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IDENTIFICATION OF KEY MOLECULES IN PLACODE-DERIVED NEURONS THAT COORDINATE CHICK TRIGEMINAL GANGLIOGENESIS
… from the coalescence of neural crest cells and placode cells. These progenitor cells give rise to trigeminal sensory neurons, with placode cell differentiation occurring first. While the dual cellular origin of the trigeminal ganglion has been known for decades, the molecular mechanisms …
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The Role of Pax3 in Neuronal Differentiation of the Ophthalmic (OpV) Trigeminal Placode and Neural Tube during Chicken Embryonic Development
… involved in trigeminal ophthalmic (opV) placode development. While Pax3 expression coincides with opV neuron specification, the function of Pax3 in these cells has not previously been investigated. Splotch mutant mice (which lack Pax3) have a reduced trigeminal ganglion; however it is not …
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FROM A PLACODE PROGENITOR PLATFORM TO A TRIGEMINAL GANGLION ORGANOID: MODELLING SENSORY DEVELOPMENT AND FUNCTION IN VITRO
… vitro, we successfully generated a multipotent placode progenitor organoid (PPO) composed almost exclusively of cells expressing the placodal marker SIX1. To guide PPOs towards an intermediate fate expressing PAX3, we performed a high-content chemical compound screen and identified novel …
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Investigating histone H3 Lys4 and Lys9 methylation in conditionally immortalized olfactory placode by matrix-assisted laser desorption
Published studies have shown that distinctive site-specific histone H3 methylation patterns at lysine 9 and lysine 4 determine the formation of heterochromatin oreuchromatin, respectively. The biological significance of lysine 4 and lysine 9 methylation of histone N-terrriinal tails was …
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An analysis of the role of microtubules during tubulogenesis in Drosophila
… and invagination of a polarised epithelial placode, as a model to understand these changes. The role of microtubules (MTs) during morphogenetic processes such as this are not well understood. In order to ascertain their role in successful tubulogenesis I looked at both stable and newly …
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Role of Xenopus Pitx3 during early development.
… induction in the presumptive lens ectoderm, lens placode, and later in differentiating lens. During tailbud stages, xPitx3 is also expressed symmetrically in the pituitary, lateral plate mesoderm, branchial arches, somites, and asymmetrically in looping gut. Ectopic expression assays suggest that …
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The transcription factors Pax-6 and X-dll3 influence visual and olfactory system development in Xenopus laevis
… eye formation, and a reduction of the olfactory placode. Both Xenopus A and Xenopus B can elicit the reduction of both lens and olfactory placodes, and the expansion of retinal tissue, while only Xenopus A can elicit ectopic eye formation and ectopic lens crystallin expression. These studies …
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
… from an ectodermal thickening, the otic placode, which invaginates and forms the otic vesicle. The otic placode gives rise to the hearing (cochlea) and balance (vestibular) organs, comprising the sensory hair cells and sensory neurons of the cochlear (spiral) and vestibular ganglia. In …
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The development and evolution of vertebrate oxygen-sensing cells
… nodose neurons are considered to be nodose placode-derived. Using electroporation and grafting in the chick, I confirmed that the nodose placode does not contribute to the carotid body, identified a small population of autonomic neural crest-derived neurons in the nodose ganglion, and …
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GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT
… was initially elevated in invaginating lens placode, but by lens vesicle stage, Ras signaling antagonist Sprouty2 was up regulated, followed by rapid decrease in ERK phosphorylation. Only after intraperitoneal treatment of U0126, an inhibitor of ERK phosphorylation, was lens development …
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Immortalisation, characterisation and differentiation of temperature sensitive cell lines from the Olfactory Neuroepithelium
… environment. Basal cells in the olfactory placode are the source of this replacement. Each olfactory neuron expresses only one or a few of the many olfactory receptors that are encoded by the large array of olfactory genes. Despite this limited cellular display of receptors, vertebrates are …
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NOVEL INSIGHTS INTO GENETIC AND ENVIRONMENTAL DETERMINANTS SHAPING GNRH NEURON BIOLOGY AND RELATED REPRODUCTIVE DISORDERS
… neurons originate from the olfactory placode during embryogenesis and migrate into the forebrain to reach the hypothalamus, where they integrate into the reproductive axis. This migratory journey depends on tightly regulated molecular mechanisms involving transcription factors, …
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New insights into cornea-lens regeneration in Xenopus laevis: the role of Wnt/beta-catenin signaling and the regenerative capacity of the limbal region
… during the initial formation of the lens placode from the surface ectoderm during early embryogenesis of the vertebrate eye. This similarity between larval lens regeneration and embryonic lens development may not be surprising when one looks at the histological structure of the larval …