Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"placental insufficiency"”.
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Recapitulation of Human Placental Insufficiency in a Novel Mouse Model :New Paradigm in Translational Research
Objective: To develop a mouse model of placental insufficiency (PI) that recapitulates important characteristics of the human PI. We tested the effects of selective reduction of placental blood flow by mesenteric uterine artery branch ligation (MUAL) reliably resulting in fetal growth restriction …
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The use of a neural network to recognize placental insufficiency from blood flow velocity waveforms in the umbilical cord
… flow waveform shape patterns associated with placental insufficiency. Eleven backpropagation neural networks have been developed and trained based on the waveforms that are generated from the foetal mathematical model (developed in previous research) at both ends of the cord. Only two networks …
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The effect of introducing Basic Antenatal Care Plus and Umbiflow on antenatal care and perinatal mortality
… are thought to be due to unrecognised placental insufficiency. No effective strategies to detect placental insufficiency are available in low- and middle-income countries. The objective of this thesis is to test strategies which if implemented would reduce these two major categories of …
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Theoretical and technical aspects of using the Doppler umbilical flow waveform to assess compromised foetal circulation
… for normal foetuses. b) the effect of placental pathology and maternal hyperoxygenation in compromised foetuses. 2. Model the foetal circulation to investigate the effect, on the umbilical flow waveform, of physiological changes resulting from placental insufficiency. 3. Perform a …
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Placental angiogenesis and immune-privilege in normal and pathological pregnancies
… that diminished levels were associated with placental insufficiency. Moreover, experiments using hypoxia provided evidence for significantly enhanced expression and secretion of angiogenin with a concomitant loss of VCAM-1, thus indicating a role for these pivotal peptides in IUGR. Additional …
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Axis of placental ageing in adverse pregnancy outcomes
… a result of various genetic, environmental, or placental factors. Premature ageing of the placenta in pregnancy outcomes such as PE and IUGR is associated with the persistent presence of oxidative stress and placental insufficiency reducing its functional capacity. Placental proteomics has been …
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Circulating microparticles: a risk factor for recurrent abortion in women at the University Teaching Hospital
… of conception before 28 weeks’ gestation. Placental insufficiency as a result of thrombi lodging in the uteroplacental bed is considered to be a cause of pregnancy loss. Circulating microparticles are minute sized particles associated with prothrombotic nature and have been found to be …
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Circulating microparticles: a risk factor for recurrent abortion in women at the University Teaching Hospital
… of conception before 28 weeks’ gestation. Placental insufficiency as a result of thrombi lodging in the uteroplacental bed is considered to be a cause of pregnancy loss. Circulating microparticles are minute sized particles associated with prothrombotic nature and have been found to be …
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Fetal Cardiac Function and Venous Circulation - Experiences with Velocity Vector Imaging
Placental dysfunction resulting in intrauterine growth restriction (IUGR) is a common complication of pregnany and severe IUGR, with ensuing fetal hypoxia is an important cause of perinatal mortality and morbidity. Doppler studies of fetal and maternal vessels are routinely used for fetal …
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Maternal Cardiac Autonomic Function and Fetal Behaviour in Hypertensive and Obese Pregnancies
… hypertension in pregnancy is associated with placental insufficiency and fetal growth restriction, whereas obesity in pregnancy is associated with placental inflammation and macrosomia. Fetal growth restriction is associated with an increased risk for language deficits at 2-5 years of age. …
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Effects of intrauterine dynamics on steroidogenesis and conceptus development in the porcine
Intrauterine crowding and placental insufficiency are main reasons for prenatal losses in swine. Two studies were conducted to examine: 1) conceptus development and in vitro steroidogenic capability of three regions of the placenta (middle, inner, polar) at d 30, 50, 70, and 90 of gestation; and 2) …
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A semiquantitative and qualitative histopathologic assessment of the effect of type II intrauterine growth retardation on the structure of the carotid bodies in fetuses and neonates
… has been ascribed, amongst other causes, to placental insufficiency that results in chronic hypoxia in the fetus. Intrauterine growth retardation can be divided into two types: - Type I (symmetrical) and type II (asymmetrical). In Type II intrauterine growth retardation, growth retardation …
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Administration of arginine does not alter material circulating concentration of C-type natriuretic peptide in pregnant sheep: A thesis submitted in partial fulfilment of the requirements for the Degree of Bachelor of Science with Honours
… CNP concentration is not a result of fetal/placental signalling of nutritional constraint.
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Role of PABP4 in intrauterine growth restriction
… including reduced fetal growth: (I) altered placental morphology/function, (II) maternal and fetal nutrient status, and (III) maternal haematology. Previous work had not considered effects of fetal sex, despite adverse pregnancy conditions (e.g. uterine stresses, nutrient deficiencies) often …