Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"placental function"”.
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Improving Segmentation and Registration of the Placenta in BOLD MRI
… Dependent (BOLD) MRI images are used to study placental oxygen transport. To analyze the time series dataset of BOLD MRI images of the whole uterus for placental function, we need to segment the placenta in the images and register the images to a common template. In the following thesis, we …
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The Placenta Methylome: Novel Insights into DNA Modifications in the Human Placenta
… and is marked by global hypomethylation. The placental methylome has been shown to modulate developmental processes, intrauterine exposures, and placental function. However, the precise mechanisms underlying DNA methylation in regulating placental function and fetal development remains poorly …
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Effects of mid-gestational L-citrulline supplementation to twin-bearing ewes on umbilical blood flow, placental development, and lamb production traits
… supplementation on umbilical blood flow, placental function, neonatal lamb size, and lamb performance. We hypothesize that i.v. administration of L-citrulline will increase uterine and placental blood flow in gestating ewes and this will improve fetal growth, development, and overall …
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The role of uterine natural killer cell-inhibition in pregnancy
… uterine vascular adaptation to pregnancy, placental function and transcriptome, as well as fetal growth. Immune checkpoint blockade of NKG2A during pregnancy in wild-type mice did not affect fetal growth, suggesting acute ablation of this pathway does not interfere with pregnancy outcome. …
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The effects of leptin on placental development and function, and offspring behavior in mice
… hormone also plays a role in implantation and placental development and function, as well as programming behavior via alteration of brain function. The current research provides insight into how leptin is involved in placental and fetal development. The goal of the first study was to determine …
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Volumetric mesh parameterization to a canonical template
… effective visualization of local anatomy and function. Monitoring placental function in vivo promises to support pregnancy assessment and to improve care outcomes. We aim to alleviate visualization and interpretation challenges presented by the shape of the placenta when it is attached to the …
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Volumetric Mapping for Medical Imaging and Geometry Processing
… resonance imaging (MRI) of the placenta to study placental health and function. This application presents a challenging problem setting relevant for mapping tasks in computer graphics and geometry processing as a whole. We propose an automatic segmentation method to extract placental shapes from …
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The Development of Certain Enzymes and Iso-Enzymes During Normal Pregnancy
… in maternal serum enzymes is the placenta. Placental specific isoenzymes of leucine aminopeptidase, alanine aminopeptidase, cystine aminopeptidase were characterized by electrophoresis and by the use of activators and inhibitors. The isoenzymes of liver also found present in pregnancy serum …
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Chronic Gestational Inflammation: Comparisons of Obesity-Mediated and Preeclampsia-Mediated Placental Inflammation using Transcriptomic and Histological Methods
… these divergent chronic inflammatory insults on placental development and function remain elusive. Preliminary work by our group suggests placental NAD+ depletion and subsequent mitochondrial dysfunction may be common pathophysiology features. Using rodent MO- and PE-mediated gestational …
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Fetal Cardiac Function and Venous Circulation - Experiences with Velocity Vector Imaging
Placental dysfunction resulting in intrauterine growth restriction (IUGR) is a common complication of pregnany and severe IUGR, with ensuing fetal hypoxia is an important cause of perinatal mortality and morbidity. Doppler studies of fetal and maternal vessels are routinely used for fetal …
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The placenta in adverse maternal environments; exploring how hypoxia and food restriction limit fetal growth
… the placenta in adverse conditions, the distinct functional zones of the mouse placenta, the endocrine junctional zone (JZ) and the labyrinth zone (LZ), which is responsible for transport, have been examined separately. Where possible, analyses have been performed on placentas from both male and …
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Post-Transfer Outcomes in Cultured Bovine Embryos Supplemented with Epidermal Growth Factor, Fibroblast Growth Factor 2, and Insulin-Like Growth Factor 1
… transferable embryo quality and post-transfer placental and fetal development. For each replicate (3 total), slaughterhouse-derived bovine oocytes were matured and fertilized in vitro. At day 4 post-fertilization, ≥8 cell embryos were harvested, pooled, and exposed to either the EFI treatment …
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Phenotypic and Functional Characterisation of Hofbauer Cells Across Gestation
… interface between the mother and baby. A normal functioning placenta is crucial for a successful pregnancy. As the placenta develops, highly branched villous tree-like structures form which contain fibroblasts, immature capillaries and macrophages, termed Hofbauer cells (HBC). HBC are the only …
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The effect of maternal obesity/GDM and metformin intervention on maternal, placental and fetal health
… such as Gestational Diabetes Mellitus (GDM). Placental function is often affected in obese and GDM pregnancies, which affects fetal growth and development. Recent years have implicated placental extracellular vesicles (EV) in fetal-maternal communication, with their microRNA (miRNA) content …
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Understanding the effects of maternal undernutrition in early gestation on placental development in late gestation
… (MUN) during earlygestation permanently alters placental development, the mechanism by whichthis occurs, and whether leptin acts as a mediator.The relationship between the maternal environment and long-term healthof offspring is referred to as the developmental origins of health and disease …
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The placenta and cardiovascular disease: A meta-analysis
… search indicated that the association between placental weight and CVD risk had been investigated in a total of 109,721 participants across eight countries. The meta-analytical process initially indicated that higher blood pressure was related to a lighter placenta. On further inspection of the …
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Examination of Placenta and Child Saliva Samples Associated with Childhood Allergy Development
… susceptibility via environmental influences on placental function and fetal programming. We hypothesised that childhood susceptibility to allergy is increased through significant alterations in placental gene expression involved in regulating immune system development. Furthermore, we …
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CHARACTERIZATION OF PLACENTAL AUTOPHAGY AND BIOENERGETICS, AND MATERNAL MICRORNAS PROFILING IN OBESE PREGNANCIES AND GESTATIONAL DIABETES MELLITUS
… Diabetes Mellitus (GDM) prevalence. The altered placental function and intrauterine environment of MO and GDM are associated with adverse maternal and fetal outcomes, with short- and long-term complications. Growing evidence suggests that both MO and GDM are characterized by placental autophagy …
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The effect of introducing Basic Antenatal Care Plus and Umbiflow on antenatal care and perinatal mortality
… are thought to be due to unrecognised placental insufficiency. No effective strategies to detect placental insufficiency are available in low- and middle-income countries. The objective of this thesis is to test strategies which if implemented would reduce these two major categories of …
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Sex differences in human perinatal development and autism
… (Generation-R) that studied the levels of placental function markers in maternal serum (n=3469), their sex differences in the general population, their association with both autistic traits in childhood (assessed using the Social Responsiveness Scale - SRS), and with likelihood for autism …
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