Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"piwi-interacting RNAs"”.
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Roles of piwi-interacting RNAs and small interfering RNAs in regulating gene expression in Caenorhabditis elegans
There are three distinct classes of small RNAs found in animals: microRNAs (miRNAs), piwi interacting RNAs (piRNAs), and small interfering RNAs (siRNAs). miRNAs are required throughout development, whereas piRNAs and siRNAs are best known for their roles in germline development and genome defense …
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Analysis of variation in PIWI-interacting RNA (piRNA) expression in testes of different mouse strains
Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs present in the germline of most animals which are responsible for silencing transposable elements (TEs) through base-pair complementarity. We performed an extensive study of the expression of piRNAs in the male germline of five …
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Small regulatory RNAs in mammals : genomics, function and evolution
… thesis explores two aspects of small regulatory RNAs in mammals: (1) the genomic origin of mammalian piwi-interacting RNAs (piRNAs), (2) the evolutionary and functional implication of the seed-based target recognition mechanism of microRNAs (miRNAs). First, we participated in the discovery of …
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Characterization of Small Non-Coding RNAs in the Seminal Plasma of Beef Bulls with Predicted High and Low Fertility
<p>MicroRNAs (miRNAs) are a family of small non-coding RNAs (sRNA) that play a key role in regulating gene expression by binding to their complementary mRNA and altering translation. It has been reported that this down-regulation of specific areas of the genome plays a role in male fertility. …
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Small RNA studies in Drosophila melanogaster, Stylophora pistillata and Symbiodinium sp.
Small non-coding RNAs such as microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs) play a big role in regulating gene expression in cells. In my work, I focus primarily on miRNAs, which represses the expression of the mRNA targets post-transcriptionally. For …
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Sequence and structure requirements of Y RNA-derived small RNA biogenesis
Numerous small non-coding RNAs have been identi�ed in mammalian cells, including microRNAs and piwi-interacting RNAs. The patterns of gene expression within cells can be altered in response to cellular stress. To examine the e�ects of cellular stress on all small RNA types, a number of human cell …
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Functional analysis of the Argonaute family proteins during early embryonic and germ cell development in the mouse
… through their association with small non-coding RNAs. Specifically in mammals, microRNAs (miRNA) and short interfering RNAs (siRNAs) bind to Ago-like subclade of the Argonaute family to regulate gene expression, while Piwi-interacting RNAs (piRNAs) associate with PIWI proteins to silence …
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Exploiting the Conflict Within: Examining Tripartite Interactions for Development of Next Generation Mosquito Microbiome Vector Control Strategies.
… lead to dramatic increases in short interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs). Additionally, 17 host miRNAs had altered levels across multiple time points. Finally, the mosquito RNAi response to ZIKV targeted the NS5 region, while ZIKV in response produced virus-derived …
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Studies on the mammalian piRNA pathway in cancer cells
Piwi-interacting RNAs (piRNAs) are a subset of noncoding RNAs that complex with members of the Argonaute protein family, the Piwi proteins. The Piwi/piRNA pathway is highly conserved in animals and is implicated in spermatogenesis, germline stem cell maintenance, and transposon suppression in the …
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Modulation of Alphaviruses by Small RNAs
… intermediates (RIs) into small interfering RNAs (siRNAs; ~21-24 nucleotides). One strand of the siRNA duplex guides the targeting and destruction of complementary viral RNAs when loaded and retained in a multi-protein complex called the RNA-induced silencing complex. Here, we show that …
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The Role of Hiwi in Stem Cell Maintenance and Sarcomagenesis
… have identified elevated expression of the human Piwi homolog--called Hiwi--in a variety of human cancers, including gastric cancer, pancreatic cancer, gliomas and, most relevant for this dissertation, sarcomas. In sarcomas, Hiwi is highly expressed and elevated Hiwi prognosticates shorter patient …
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Microhabitat, microbiota, mitochondria and the epigenome shape the biparental legacy of heat exposure in a tropical arthropod
… through targeted destruction by non-coding RNAs known as PIWI-interacting RNAs. Approximately 70% of the C. scorpioides genome consists of transposable elements/highly repetitive regions, an unusually high level for an arthropod species, making transposable element expression a likely factor …