Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"piperidine derivatives"”.
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Sythesis and Biological Screening of a Series of Novel Chemokine Receptor CCR5 Antagonists
… of cancers and AIDS. A series of novel piperidine derivatives were designed, synthesized, and evaluated as CCR5 antagonists. The ability of the new ligands to inhibit the increment of intracellular calcium level stimulated by endogenous ligand CCL5 was measured in the calcium …
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Studies on the monoamine oxidase substrate/inactivator properties of piperidine analogs of the neurotoxin MPTP
… saturated analogs. Several 1,4-disubstituted piperidine derivatives were synthesized and their interactions with MAO-A and MAO-B were characterized. These compounds displayed poor substrate properties toward MAO-A and MAO-B and led to the expected α-carbon oxidized metabolites which were fully …
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HYPERVALENT IODINE-MEDIATED HETEROCYCLIC GROUP TRANSFER REACTIONS TO OXIDATIVE OLEFIN DIFUNCTIONALIZATION
… scaffolds can be used as precursors to valuable piperidine derivatives and have recently emerged as important cross coupling handles for metal-catalyzed processes. Unfortunately, current methods to access pyridinium salts are limited; they require harsh conditions, rely on the presence of an …
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Novel, High Activity Hydroprocessing Catalysts: Iron Group Phosphides
… by comparing the HDN activity of a series of piperidine derivatives of different structure. It was found that piperidine adsorption involved an a-H activation and nitrogen removal proceeded mainly by means of a b-H activation though an elimination (E2) mechanism. The relative elimination rates …
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Stereoselektive Totalsynthese verschiedener Cassia- und Microcos-Piperidinderivate : Synthese des (-)-Cassins
Unser Ziel war es, einen neuen Zugang zu den sehr ähnlichen Cassia- und Microcos-artigen Piperidinalkaloiden zu finden. Aus dem „chiral pool“ wurde der L-Zucker Rhamnose als Ausgangsmaterial gewählt. Diese wurde zunächst in einen Azidoaldehyd, einem flexiblen Synthesebaustein zur Darstellung von …