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Showing 1 to 20 of 78 for “"piperidine"”.
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Synthesis and Characterization of 1-Methyl-4-Substituted-3-Piperidine-Carboxylic Acid N, N-Diethyamide.
Following the suggestion by Smythies that the major hallucinogens, mescaline, N,N-dimethyltryptamine (DMT) and d-lysergic acid diethylamide (d-LSD) all act at the same site, namely, the serotonin (5-hydroxytryptamine) receptor in the brain, it was found that 1-methyl-1,2,5, …
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Piperidine alkyl para amino benzoates and derivatives; Synthesis of compounds homologous to eccaine and cocaine
Made available in DSpace on 2017-11-30T21:03:38Z (GMT). No. of bitstreams: 2 2320410.pdf: 4062644 bytes, checksum: 247999062d688938a0b77be1a99e12e8 (MD5) license.txt: 4813 bytes, checksum: 715c4321821a960fa1a1e91d2ac7ebce (MD5) Previous issue date: 1927
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Studies on the monoamine oxidase substrate/inactivator properties of piperidine analogs of the neurotoxin MPTP
… saturated analogs. Several 1,4-disubstituted piperidine derivatives were synthesized and their interactions with MAO-A and MAO-B were characterized. These compounds displayed poor substrate properties toward MAO-A and MAO-B and led to the expected α-carbon oxidized metabolites which were fully …
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The Chemistry of Aroyl Azides in Piperidine- and Steroid-Separated Bichromophoric System: Photoinduced Long-Distance Intramolecular Electron Transfer Reactions
The photochemistry and photophysics of piperidine- and steroid- separated bichromophoric systems containing an aroyl azide as the electron acceptor and secondary aromatic amines as the electron donors was examined. We report the first example of unique photochemical reactivity associated with …
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Functional Block Copolymers via Anionic Polymerization for Electroactive Membranes
… crosslinked materials. 4-Vinylbenzyl piperidine is a novel styrenic compound that observably autopolymerizes. In situ FTIR spectroscopy monitored styrene and 4-vinylbenzyl piperidine thermal polymerizations. A pseudo-first-order kinetic treatment of the thermal polymerization data …
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A Conductometric Study of the Reaction Velocities of 2, 4-Dinitrochloro, Bromo, and Iodobenzene with Piperidine in Dimethylsulfoxide at Various Concentrations and Temperatures
… of the reaction of 2,4-dinitrohalobenzene with piperidine in ethanol using a conductometric method. L. E. Youngberg concluded that this method permits greater precision than either the titrimetric or spectrophotometric techniques which involve quenching of reaction aliquots. Significant reaction …
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Alpha-lithioamine synthetic equivalents from N-Boc secondary amines: Piperideine, pyrrolidine, and perhydroazepine
… from unactivated cyclic secondary amines; piperidine, pyrrolidine, and perhydroazepine to provide $\alpha$-lithioamine synthetic equivalents. The Boc group can be easily introduced on the nitrogen, stable to strong alkyllithium bases, and easily cleaved after elaborations. Determination of …
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SOME CHEMICAL CONSTITUENTS OF THE BROWN ALGA, AGARUM CRIBOSUM AND THE EFFECT OF ELECTROSTATIC INTERACTIONS ON THE STEREOCHEMISTRY OF THE S(N)2' REACTION
… The substrate was reacted with two nucleophiles, piperidine and sodium propanethiolate. To the extent that transition state electrostatic interactions can influence the direction of nucleophilic attack, it was expected that piperidine would attack anti to the leaving group while propanethiolate …
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Asymmetric Synthesis of 1,3-Amino Alcohols and Tropinone Derivatives From Enantiopure Sulfinimines
Heterocycles that contain nitrogen, such as piperidine, pyrrolidine and tropane, are widespread as natural product alkaloids and serve as templates for many bioactive drugs and drug candidates. The intent of this research is to the develop asymmetric syntheses of piperidine-containing syn and anti …
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The electronic absorption spectra of di- and tri-arylmethane dyes containing fluorine
… known dimethylamino- analogues. The readiness of Piperidine Violet and its 2'-trifluoromethyl derivative to protonate when in strongly acidic media was not shared by their pyrrolidine analogues. This behaviour was illustrated by the production of Piperidine Green type spectra for these dyes when …
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Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs)
… made on the aryl ring, the ester moiety and the piperidine nitrogen of meperidine. Potent analogues of the aryl substituted series that included 4-iodophenyl, 2-naphthyl, 3,4-dichlorophenyl and 4-biphenyl meperidine derivatives were synthesized and chosen for further optimization of the benzyl …
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Tandem Double Intramolecular [4+2]/[3+2] Cycloaddition of Nitro Olefins: Part I: Construction of Piperidine Rings. Part II: Construction of Vicinal Quaternary Stereogenic Centers. Part III: Progress Toward a Total Synthesis of Daphnilactone B
The fully functionalized nitroalkene intermediate for the total synthesis of daphnilactone has also been prepared and participated in the high yielding tandem double-intramolecular [4+2]/[3+2] cycloaddition to provide a mixture of two epimeric nitroso acetals. Ozonolysis of the cycloadducts, …
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Part One: Epr, Thermodynamic, and Hydrogen Bonding Studies of Cobalt Dioxygen Complexes and Part Two: Structural, Spectral, and Magnetic Properties of a Copper(ii) Bimetallomer
… were determined for the bases piperidine, 1-methylimidazole, pyridine, and tetrahydrothiophene. The enthalpies were fit to the E and C correlation, allowing E(,A) and C(,A) parameters to be calculated for Co(4,6-CH(,3)Osal-4-CF(,3)oph).
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Cytotoxic Alkaloids from Microcos paniculata with Activity at Neuronal Nicotinic Receptors
… countries in South and Southeast Asia. Three new piperidine alkaloids, microgrewiapines A-C, and a number of known compounds were isolated from cytotoxic fractions of the separate chloroform-soluble extracts of the stem bark, branches, and leaves of M. paniculata. Comprehensive structure …
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HYPERVALENT IODINE-MEDIATED HETEROCYCLIC GROUP TRANSFER REACTIONS TO OXIDATIVE OLEFIN DIFUNCTIONALIZATION
… scaffolds can be used as precursors to valuable piperidine derivatives and have recently emerged as important cross coupling handles for metal-catalyzed processes. Unfortunately, current methods to access pyridinium salts are limited; they require harsh conditions, rely on the presence of an …
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