Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"piperazine"”.
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Corrosion study of iron using piperazine derivatives as inhibitors
… and lack of strain on the bonds in the ring. Piperazine, a cyclic six membered ring CHNH, has not been studied as a corrosion inhibitor. This poor base and some of its simple derivatives were chosen to study as inhibitors because of the possibility of dual adsorption through both nitrogen …
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Modeling of carbon dioxide absorption/stripping by aqueous methyldiethanolamine/piperazine
Rigorous thermodynamic and kinetic models were developed in Aspen Plus® Rate SepTM for 8 m PZ, 5 m PZ, 7 m MDEA/2 m PZ, and 5 m MDEA/5 m PZ. Thermodynamic data was regressed using a sequential regression methodology, and incorporated data for all amine, amine/water, and amine/water/CO₂ systems. The …
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Modular Synthesis and Hydroalkylation of Vicinally Functionalized Ketopiperazines: A solution to the Piperazine Problem
The stereocontrolled synthesis of functionalized piperazines is of great interest to pharmaceutical companies owing to their multiple biological activities such as antidepressant, antiparasitic, anticancer and antiretroviral. Current methods towards functionalized piperazines include intramolecular …
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In silico-guided design, synthesis and antimicrobial activity of piperazine-linked 8-hydroxyquinoline-isatin hybrids
… The aim of the study was to synthesize piperazine-linked 8-hydroxyquinoline-isatin hybrids, with and without the thiosemicarbazide unit, and to evaluate their antimicrobial activities. In silico studies of the hybrids were done using open-source absorption, distribution, metabolism, …
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Random search conformational analysis of piperazine and piperadine analogs of GBR12909 : implicit aqueous solvation effects
The object of this work was to study the effect of solvent on the conformational potential energy surface (PES) of GBR12909 analogs. Local minima on the PES's were found by the Random Search algorithm using the Sybyl molecular modeling package from Tripos, Inc., and an implicit solvent model. Two …
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Piperazine-based pyrido[1,2-a]benzimidazoles: synthesis and pharmacological evaluation as potential antimalarial and antischistosomal agents
… derivative composed of a cyclohexyl piperazine side-chain (33), showed improved in vitro activity against the NF54 strain of P. falciparum (IC50 = 0.012 µM) and enhanced solubility (Figure A). Compounds with methylene or ethylene linkers at the R1 position (Figure A) showed comparable …
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Synthesis of Bicyclic and Tricyclic Analogues of Oxazolidinone
… the design and synthesis of the fused tricyclic piperazine analogues and tricyclic triazole analogues of ANB-22 and ANB-40. </p><p>By employing the aziridine-ring-opening and the Mitsunobu reaction, a series of fused bicyclic and tricyclic oxazolidinone-piperazine derivatives have been prepared. …
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Structure-Based Drug Design in Medicinal Chemistry I. Development of Translesion Synthesis Inhibitors II. Synthesis and Biological Evaluation of Sulfonyl Piperazine Derivatives for LpxH Inhibition
<p>The identification of a promising lead compound is a crucial step for the drug development. Despite of a number of approaches, the optimization of promising hit compounds is still challenging. Structure-based drug design approach is a well established and widely used strategy based on the 3D …
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Design and Synthesis of Novel Cage-Functionalized Crown Ethers: A New Class of Ag Complexants.
… overall complexation ability of the host system. Piperazine groups may cooperate, and the piperazine nitrogen atoms provide unshared electrons, which may form a complex with Ag+. In addition, relatively soft donor atoms (e.g., Br) are well-suited for complexation with Ag+, which is a softer Lewis …
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A comparative study of gastrointenstinal nematode infection in traditional and commercial chickens and efforts of anthelminthic treatment on production
… of a commonly used anthelmintic in Zambia, piperazine (lOOOmg P.HC1) in comparison with two other anthelmintics i.e. albendazole (75% m/v) and levamisole (25% m/v). Percentage efficacy against Ascaridia galli was 100%, 100% and 52.4%, for albendazole, levamisole and piperazine respectively. …
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A comparative study of gastrointenstinal nematode infection in traditional and commercial chickens and efforts of anthelminthic treatment on production
… of a commonly used anthelmintic in Zambia, piperazine (lOOOmg P.HC1) in comparison with two other anthelmintics i.e. albendazole (75% m/v) and levamisole (25% m/v). Percentage efficacy against Ascaridia galli was 100%, 100% and 52.4%, for albendazole, levamisole and piperazine respectively. …
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Modeling of flexible drug-like molecules : qsar of GBR 12909 analog dat/sert selectivity
… reuptake inhibitor GBR 12909 and related dialkyl piperazine and piperidine analogs have been studied as agonist substitution therapies acting on the dopamine transporter (DAT) to treat cocaine addiction. Undesirable binding to the serotonin transporter (SERT) can vary greatly depending on the …
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Application of Chemiluminescent Detection to a Capillary Electrophoresis System Contained on a Glass Slide and the Development of Non-Flowing Electrogenerated Chemiluminescence Probes
… and its major metabolite 1-(2-pyrimidyl)piperazine were added to a human plasma matrix. The drug and metabolite were then separated from this matrix and detected.
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New lithiation methodologies to 2-substituted nitrogen heterocycles
… an N-Boc acetal piperidine, N-Boc-Nʹ-benzyl piperazine, N-Boc-Nʹ-i-Pr imidazolidine and an O-alkyl carbamate in diethyl ether using s-BuLi and the diamines TMEDA, (–)-sparteine, or the (+)-sparteine surrogate. Chapter 3 describes the expansion of a previously reported two-ligand catalytic …
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Automated Synthesis of Duplex-Forming Recognition-Encoded Oligomers
… oligomers (REMOs) composed of alternating piperazine and triazine units, equipped with phenol and phosphine oxide hydrogen-bonding groups, have been shown to form sequence- and length- selective duplexes and are a promising candidate for such a system. An automated solid-phase synthesis …
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Fragment-based approaches to targeting EthR from mycobacterium tuberculosis
… was explored was a 4-(4-(trifluoromethyl)phenyl)piperazine using fragmentgrowing from the NH of the piperazine to probe deeper into the EthR binding pocket. In addition to this, SAR around the 4-(trifluoromethyl)phenyl group was assessed to explore the interactions with EthR. These modifications …
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