Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"pioneer factors"”.
-
Pioneer Factors Compete for Epigenetic Factors in Switching Stem Cell Fates
… malignancy. At the crossroads of fate-switching, pioneer factors are a class of transcription factors equipped to bind cognate motifs in closed chromatin. Once they access the closed chromatin, pioneer factors can either act as transcriptional activators or repressors of cell fates by recruiting …
-
Molecular mechanisms of pioneer factor ELF2 interactions with the nucleosome
Pioneer factors are a subset of transcription factors (TFs) that can bind to nucleosomes and regulate gene expression at closed chromatin regions. Pioneer factors are important for stem cell pluripotency, cell reprogramming and differentiation. ETS family TFs are a large subfamily of TFs consisting …
-
INTEGRATIVE GENOMICS UNVEILS TRANSCRIPTION FACTOR ROLES IN CELLULAR FATEAND SPATIALLY RESOLVED TRIPLE-NEGATIVE BREAST CANCER IMMUNITY CAPACITY
… projects. The first investigates transcription factors (TFs) in cellular differentiation, addressing the inefficiency in current cellular conversion strategies due to the complex TF regulatory landscape. We developed a comprehensive screening of 130 developmental TFs, comparing their dosages in …
-
Defining oncogenic determinants in prostate cancer initiation and progression
… We have delineated critical roles of the pioneer factors ASCL1 and NEUROD1 in neuroendocrine transdifferentitation and uncovered their abilities to silence AR expression and signaling by remodeling chromatin at the somatically acquired AR enhancer and global AR binding sites with enhancer …
-
The role of transcription factors in somatic cell nuclear reprogramming by eggs and oocytes
… by overexpression of combinatorial Yamanaka factors (iPS, Takahashi et al., 2006). Although both approaches aim to derive cells with highest plasticity, the mechanisms and differences between these procedures are not yet clear. In my thesis, I used quantitative polymerase chain reaction …
-
The role of FOXK transcription factors in Wnt signal transduction
… is tethered to enhancers by T-cell transcription factors (TCF), and core components include the chromatin reader Pygopus as well as the transcriptional repressor Groucho/TLE3. While much is known about the basic interactions within the enhanceosome, it remains elusive how the enhanceosome accesses …
-
Steroid receptor crosstalk in breast cancer cells.
… the genomic response of the well-established pioneer factor FoxA1. Genome-wide analysis of FoxA1 binding, upon treatment of E2 or Dex, shows that both ER and GR can recruit FoxA1 to specific binding sites within the genome through a DynaLoad mechanism. These results indicate that there is not …
-
Dissecting the role of cathepsin V in breast cancer
… Importantly, FoxA1 and GATA3, the crucial pioneer factors of ERα transcription, were also altered in cathepsin V depleted cells; therefore, it is plausible that cathepsin V may regulate ERα expression by mediating the expression of FoxA1 and GATA3. While the molecular mechanism by which …