Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"pimelate"”.
-
Biotin synthesis in Bacillus subtilis
… lies in the first stage of synthesis of a pimelate thioester moiety. Bacillus subtilis represents a group of microorganisms that follow a different pathway for biotin synthesis. Genetic and biochemical studies identified bioW and bioI as two genes required for pimeloyl-CoA and pimeloyl-ACP …
-
Biotin synthesis in Escherichia coli
… the mechanism whereby E. coli assembles this pimelate intermediate was unclear. Genetic analyses identified only two genes of unknown functions, bioC and bioH, which are required for pimelate synthesis. BioC is annotated as an S-adenosyl-L-methionine (SAM) dependent methyltransferase, whereas …
-
Metabolite biosynthetic enzymes: catalysis, substrate specificity and protein engineering
… of CoA to the seven-carbon dicarboxylate pimelate, a biotin precursor. The reaction takes place in two steps, first is the activation of the carboxylate through an adenylate intermediate followed by a thioesterification reaction to co-A resulting in pimeloyl-CoA. In the biotin biosynthetic …