Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"pilocarpine"”.
-
Sweating After Repeated Intradermal Injections or Iontophoresis of Pilocarpine or Acetyl Beta-Methylcholine
Made available in DSpace on 2014-12-09T23:34:01Z (GMT). No. of bitstreams: 1 6910740.pdf: 3066275 bytes, checksum: 4caa6469732971f10b539d15d2a1475d (MD5) Previous issue date: 1968
-
Functional Redistribution of Hippocampal Cannabinoid Cb1 Receptors in the Rat Pilocarpine Model of Acquired Epilepsy
… of seizures and epilepsy, including the rat pilocarpine model of acquired epilepsy. However, the distribution of CBl receptor expression and function in brains of epileptic rats has not been characterized. Therefore, this dissertation was initiated to evaluate the effect of epileptogenesis on …
-
Post-Juvenile Brain Development Modulates Seizure Characteristics and Diazepam Efficacy in the Rat Pilocarpine-SE Model
… the acute discrete seizure phase of the rat pilocarpine-SE model. Results for this study showed that Racine behavioral severity score, spike frequency, and seizure severity during the acute discrete seizure phase change in relation to post-juvenile brain developmental stages. The second study …
-
The Effect of Feeding, Bilateral Parotidectomy, and Pilocarpine Treatment on Parotid Hormone Secretion in the Pig
… effect of feeding, bilateral parotidectomy, pilocarpine treatment, visual and olfactory, and masticatory stimuli on parotid hormone (PH) secretion is reported. Feeding a regular chow was shown to be a potent stimulus for PH secretion. The parotid endocrine system is highly sensitive to the …
-
Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures
… 1 (CB<sub>1</sub>) in muscarinic agonist pilocarpine-induced seizures. Previous work showed that pilocarpine-induced seizures require activation of M<sub>1</sub> receptors; activation of these receptors also increases release of endocannabinoids which act at CB<sub>1</sub> receptors to …
-
Status Epilepticus Results in a Duration-Dependent Increased Protein Kinase A Activity in the Rat Pilocarpine Model
… excitability. SE was induced by injection of pilocarpine after which rats were monitored both electrographically and behaviorally. After various lengths of time in SE, specific brain regions were isolated for biochemical study. SE resulted in an early maintenance of PKA activity in both …
-
Epileptogenesis Causes Long-Term Plasticity Changes in Calbindin D-28k in the Rat Pilocarpine Model of Acquired Epilepsy
… in epileptic rats even up to one year following pilocarpine treatment. The goal of this research effort was to determine if epileptogenesis alters basal calcium levels by producing a long-term change in the expression of the major calcium binding protein in neurons, calbindin D-28k. …
-
Topical Formulation For Stimulating Sweat Secretion as an Alternative to Iontophoresis
Sweat test or pilocarpine iontophoresis test is the existing method for diagnosis of cystic fibrosis that is recommended to perform at 48 hours after birth. However, the current method is painful, with several side effects such as full thickness skin burn, skin rash, erythema etc. Therefore, the …
-
The Role of Microtubules in Secretion
… secretion in response to a known secretagogue, Pilocarpine. The in vitro model .demonstrated an interaction between microtubules and the membrane of zymogen granules. Attachment was produced by the micro-tubule side arms and possibly a membrane component. This morphological observation was …
-
Metabotropic glutamate receptors as targets for antiepileptic drug therapy: a behavioral and electroencephalographic analysis
… one is characterized by convulsive seizures (pilocarpine model) and the other is characterized by the lack of convulsive seizure, or an "absence" seizure (GBL model). Mice were given mGluR2/3 active drugs either before or after seizure onset and behavioral observations relating to seizure were …
-
Variations in the amylolytic power and compostition of the saliva
… The well known effects of Atropine and Pilocarpine on the salivary glands, as regards quantity, should be extended to include the composition and digestive properties of the secretions as well. In the present paper I shall present some results obtained from studying the variations in the …
-
Indagine etnofarmacologica su Casimiroa edulis Llave et Lex
… activity) and convulsion lithium-pilocarpine induced, while it significantly prolonged pentobarbital-induced hypnosis. The extract of leaves produced a like-anxyolitic action in the elevated plus maze test; in the FST it was as effective as fluoxetine in inducing shortening of …
-
The Effects of 5-Fluorouracil on The Secretory Process of The Rat Parotid Gland (Protein)
… following stimulation with either 5 mg/kg pilocarpine or 5 mg/kg isoproterenol in experimental, pair-fed, and control animals. Saliva from experimental animals was significantly lower in volume, amylase and protein content than both control groups. Sodium dodecyl sulfate, anionic and …
-
Development and Characterisation of Solid-State Ion-Selective Electrodes, and their Application to Sweat Analysis for Cystic Fibrosis Diagnosis
… diagnostic test for CF is the Quantitative Pilocarpine Iontophoresis Test (QPIT) for the sweat electrolytes sodium and chlorideii. In the QPIT, the sweat glands are artificially stimulated, a sweat sample is collected, and the concentrations of sodium and chloride ions determined separately …
-
Exploiting muscarinic acetylcholine receptors as an insecticidal target to enhance the toxicity of gamma-amino butyric acid channel blockers and the continued challenges with resistance
… Drosophila melanogaster where mAChR agonism by pilocarpine enhanced the toxicity of insecticides targeting gamma-aminobutyric acid (GABA)-gated chloride channels, indicating the potential of insect mAChRs as a target for developing novel insecticides/synergists to control resistant pests. A …
-
Formulation, Scaled & Controlled Engineering of Fibrous Dosage Technologies for Ocular Drug Delivery
… distance enabled the successful encapsulation of pilocarpine HCl into PLGA nanofibers and ovalbumin into PVP nanofibers highlighting the platforms potential in the fabrication of controlled, biodegradable ocular drug delivery systems. Novel multilayered polymeric drug delivery systems were …
-
Transcriptional response to spatial learning and foraging in honey bees: molecular bases for adult neuroplasticity
… and foraging behavior, and treatment with pilocarpine, a muscarinic cholinergic receptor agonist, produces growth of the mushroom body neuropil comparable to that produced by maturation and foraging. I have examined molecular processes associated with flight and foraging experience in the …
-
Pathological Upregulation of a Calcium-Stimulated Phosphatase, Calcineurin, in Two Models of Neuronal Injury
… brain injury.Status epilepticus was induced by pilocarpine injection. NMDA-dependent increases in calcineurin activity were observed in cortical and hippocampal homogenates. Upon closer examination, the most profound increases in activity were found to be present in crude synaptoplasmic membrane …
-
The daily rhythm of Paneth cells in <i>Mus musculus </i>
… vivo</em>, by a combination of feeding and pilocarpine stimulation (Trier <em>et al</em>, 1966, Linss 1967). In fed, pilocarpine stimulated mice, the transit time was 3 to 6 hours.</p> <p>This polar morphology of basal rough endoplasmic reticulum and apical accumulation of storage forms of a …
Page 1 of 2