Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"pigment cell"”.
-
Regulation of fate specification in stem cells of the planarian Schmidtea mediterranea
… mechanisms for producing a wide array of cell types. Neoblasts are stem cells of the planarian Schmidtea mediterranea that undergo fate specification to produce over 125 adult cell types. Fate specification in neoblasts can be regulated through expression of fate-specific transcription …
-
Studies on the cone pigment, iodopsin
… have been found against iodopsin and other cone pigments in chicken retina: (1) specifically against iodopsin (cell line of 7D3); (2) against iodopsin and another cone pigment (cell lines of 2D4, 4G2, and 5E3); and (3) against iodopsin and other three cone pigments (cell line of 2C3). One …
-
Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores
Understanding genetic and cellular bases of adult form remains a fundamental goal at the intersection of developmental and evolutionary biology. The skin pigment cells of vertebrates, derived from embryonic neural crest, are a useful system for elucidating mechanisms of fate specification, pattern …
-
Evolution and Development of Pigmentation Patterns in East African Cichlid fishes
… (xanthophores) and iridescent (iridophores) pigment cell types. The functional origin of egg-spots has been implicated in courting behaviour and sexual selection. I wish to understand the genetic, developmental, and hormonal factors that contribute to the emergence and vast variation in …
-
Evolution of Endothelin Signaling and Diversification of Adult Pigment Patterns
… evolutionary changes and mechanisms at the cellular level which drive differences in adult morphology. Pigmentation is an especially tractable trait to study mechanisms of diversification in form. Fishes of the genus Danio exhibit diverse pigment patterns that serve as useful models for …
-
Functional studies of <i>Ci-Gsx</i> gene in the developing central nervous system of <i>Ciona intestinalis</i>
… developing CNS, including the precursors of the ocellus photoreceptor cells. Clana ocellus, a pigmented multicellular photoreceptive organ, despite its simplicity, possesses functional and molecular similarities to vertebrate eye, thus representing a valuable tool to study the basic mechanisms of …
-
Evolutionary and Developmental Survey of Genes Involved in Chordate Pigmentation
The pigmentation represents one of the most interesting topics in animal life because it is a decisive factor for the evolutionary success and the conquest of new ecological niches. Through the combination of developmental biology and comparative genomics, some aspects of pigmentary dynamics have …
-
Regeneration and maintenance of the planarian nervous system
… eyes. This process depends on a population of cells in the adult, the neoblasts, that includes pluripotent stem cells. Whether the neoblast population also includes progenitors specialized for forming specific lineages has not been demonstrated. This thesis describes the identification of …
-
Role Of Type Ii Phosphatidylinositol 4-Kinases In Endosomal Tubule Dynamics During Melanosome Biogenesis
Melanosomes are pigment cell-specific lysosome-related organelles (LROs) in which melanin pigments are synthesized and stored. Melanosome maturation requires biosynthetic delivery of melanogenic enzymes (e.g. TYRP1), transporters (e.g. OCA2), and SNAREs (e.g. VAMP7) from early endosomes (EEs). One …
-
The cloning and characterisation of the chicken tyrosinase-related protein gene family
… the molecular and genetic mechanisms controlling pigmentation within the bird kingdom. The aim therefore, of this study was to contribute towards the understanding of the genetic regulation of avian pigmentation by the cloning and characterisation of the chicken Tyrosinase-related protein (TRP) …
-
Cell type-specific regulation of the chicken tyrosinase promoter
Melanin, the pigment found in the eyes and coats of vertebrates, is synthesised by two main cell types: melanocytes and retinal pigment epithelial (RPE) cells. These two cell populations. which arise from distinct embryological origins, differ with respect to the rate at which they produce melanin …
-
Understanding cornea stem cells during homeostasis and wound healing in Xenopus
… wound healing are supported by specialized stem cells, that include the cornea epithelial stem cells (CESCs). Damage to or loss of these cells results in blindness and other debilitating ocular conditions. Here, we focus on cornea epithelial stem cell deficiency (commonly called limbal stem cell …
-
Colouration evo-devo: the developmental basis of intra-specific variation in cichlid pigmentation
… (GWAS) identified oca2, a gene required for pigment synthesis in melanophores, as a candidate associated with egg-spot number variation. I present a study of A. calliptera egg-spot development and the developmental basis of intra-specific variation in egg-spot number. First, I characterise …