Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"pi-stacking"”.
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Role of aromatic pi-stacking on the aggregation of human islet amyloid polypeptide (hIAPP)
… Aggregation is thought to be mediated by pistacking interactions between phenylalanine residues of hIAPP. In this study, the hIAPP 1-19 sequence was modified by replacing phenylalanine with alanine and naphthylalanine, to study if the modification of the aromatic side chain alters …
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Platinum Complexes and Zinc Finger Proteins: From Target Recognition to Fixation
… in a loss of cytotoxic properties due to rapid deactivation through binding to S-containing proteins. This enhanced reactivity yields new opportunities to study the reactions between proteins and DNA. One of the first crosslinking experiments used transplatin to crosslink NCp7 to viral RNA …
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Synthesis and Applications of Novel Responsive Materials
… polymerization or macrocyclization and pi-stacking depending on the length of the oligomer. The supramolecular properties of these responsive polymers are attributed to the palladium-pyridine coordination and pi-pi stacking. A responsive hydrogel, sensitive to changes in pH, was coupled …
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Part I. Molecular Tweezers: Synthetic Receptors for Nucleotide Bases. Part II. Molecular Self-Assembly: Design of a Helical Aggregate
… The cooperativity of hydrogen bonding and $\pi$-stacking interactions resulted in the efficient complexation of 9-propyladenine by 28, a association constant of 25,000 M$\sp{-1}$ was measured. The nucleoside selectivity of 28 was also studied. Studies suggested that the unique …
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Molecular tweezers: Synthetic receptors for the DNA base adenine
… through a combination of hydrogen bonding and $\pi$-stacking interactions. They were synthesized in a convergent fashion that was fast and efficient. A new methodology for 9-substituted acridines was developed to facilitate the syntheses of molecular tweezers containing acridine chromophores. A …
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Electron- and ion-conducting metal-organic frameworks
… H₄TTFTB, a ligand with a high propensity toward [pi]-stacking. Because understanding intermolecular [pi]-stacking interactions is important for designing through-space charge transport materials, we studied the significance of how the organic secondary building unit (SBU), which is energetically …
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Synthesis towards synthetic adenosine receptor
… was done to synthesize two clamps, namely the [pi]-[pi] stacking clamp and the hydrogen bonding clamp for the proposed tweezer. These two clamps in coordination with Zn^{+2} ions intended to form a pre-organized tweezers molecule for more favorable complexation with adenosine.
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Induced pi-facial discrimination in the alkylation of chiral derivatives of glycine.
… when reacting electrophiles of increasing pi-character. When the chiral auxiliary contained a naphthyl group the stereoselectivity was >80% for every electrophile used. Part B. The alkylation of the trans 2-phenylcyclohexylamide of methyl glycinate with a series of electrophiles was …
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Structural studies of coordination networks based on multitopic organic ligands and silver(I) salts
… Based on the complexes of silver(I) with multitopic ligands, certain recurrent relationships have been identified between topicity of the organic ligand and the network connectivity that can be used as guidelines for the construction of supramolecular structures. When crystallized from non-polar …
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Synthesis of guanidinium-functionalized amphiphiles for the exploration of chaotropic supramolecular nanoribbons
… in engineered assemblies are often bio-inspired, where structures are highly dynamic to respond to changes in their environment. Molecules within dynamic assemblies move rapidly due to molecular exchange and rearrangement, and the supramolecular structure is often only retained for a …
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Eine molekulare Fliegenfalle zur Erkennung von biologisch relevanten (poly)-anionischen Substraten
… werden, dass Flexibilität, Hydroxy-Funktionen, pi-Stacking und Symmetrie bei den Substraten Einfluss auf die Bindungskonstanten zeigen, wobei vor allem die unpolaren Wechselwirkungen und die zusätzliche Hydroxy-Funktionen einen hohen Anteil an der Bindung zu haben scheinen. Neben der selektiven …
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IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS
… with G4. This conformation is ideal for both pi-stacking with the guanine decks and polar interactions with the phosphate backbone of quadruplex DNA.
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IMPROVED SYNTHESIS OF 3-ARYL-ISOXAZOLES AS INTERMEDIATES FOR NOVEL G-QUADRUPLEX BINDING ANTI-TUMOR AGENTS
… with G4. This conformation is ideal for both pi-stacking with the guanine decks and polar interactions with the phosphate backbone of quadruplex DNA.
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Functional Materials From Self-Assembled Macrocycles
… devices. These assembled materials are typically held by non-covalent interactions such as hydrogen bonds, pi-pi stacking and dipole-dipole interactions. We are interested in developing supramolecular macrocyclic self-assemblies that could be utilized for a variety of applications. A …
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Fullerene-acene chemistry: Part I Studies on the regioselective reduction of acenes and acene quinones; Part II Progress toward the synthesis of large acenes and their Diels-Alder chemistry with [60]fullerene
… on the NMR time scale, suggesting that internal pi-pi stacking between [60]fullerenes locks the molecule into the cis conformation.</p>
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Biomimetic models for redox enzyme systems
… such molecules. Hydrogen bonds, electrostatics, pi-stacking, hydrophobic effects, solvatophobic effects and van der Waals forces are all types of noncovalent interactions. Biological systems have provided much of the inspiration for the development of supramolecular chemistry, and many synthetic …
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Synthesis, Properties, and Reactivity of Pentafluorophenyl Substituted Cyclopentadienes and Their Transition Metal Complexes
… is also characterized by infrared spectroscopic analysis of substituted CpM(CO)3 (M = Mn(I) and Re(I)) and electrochemical analysis of substituted ferrocenes. X-ray crystal structures of several C6F5-substituted Cp complexes reveal interesting structural motifs, including pi-stacking of the …
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Comparison of conventional and super-glassy polymers
… to a microporous, high performance polymer, PIM-1. PIMs are Polymers with Intrinsic Microporosity and were firstly introduced by Budd and McKoewn in the early 2000s. PIM-1 was the first synthesized PIM and, even if many more PIMs followed , PIM-1 shows the most promising gas transport …
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Diphenylalanine self-assembly- kinetics, thermodynamics and its relevance to amyloidogenesis
… properties such as high stiffness and piezoelectricity and have emerged as attractive candidates for functional nanomaterials. In addition, these structures can be made conductive or used as scaffolds for organising functional entities which do not on their own possess a propensity …
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SYNTHESIS OF CONJUGATED SMALL MOLECULES AND POLYMERS BY A PALLADIUM CATALYZED CYCLOPENTANNULATION STRATEGY – TOWARDS NEW ORGANIC SEMICONDUCTORS
… stability in comparison to n-type materials. Despite recent research into the development of n-type materials, fullerene (C60 and C70) and its derivatives are still the predominant materials used as electron acceptors for OPV applications. By taking advantage of the electron accepting behavior of …
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