Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"physiologically-based pharmacokinetic model"”.
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Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Fentanyl in Dogs
… of the bioequivalence analysis indicated the model was not equivalent. The model was examined using time averaged inputs of tissue blood flows and using stepped changes in tissue blood flow representing measured changes in individual experimental subjects. Analysis of partial areas under the …
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In Vivo Fluorometric Assessment of the Skin Microcirculation
A tissue uptake model was developed to describe the fluorescein dermofluorometer signal in terms of the local blood flow and capillary permeability. The fluorescein signal is characterized by a wash-in time constant dependent on both the blood flow and permeability. Under flow-limited conditions …
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Development of a PBPK-based health risk assessment framework for exposure to cerium, gold, silver and titanium engineered nanoparticles
… frameworks. The study managed to apply a physiologically based pharmacokinetic model for ceria nanoparticles to determine biokinetics of ceria nanoparticles, establish whether physiologically based pharmacokinetic models are a good risk assessment tool for ceria, gold, silver and titanium …
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Computational Evaluation and Structure-based Design for Potentiation of Nicotine Vaccines
… are explored. The first approach applied physiologically-based pharmacokinetic (PBPK) modeling to better assess NV potential. Rat and human physiological and pharmacological parameters were obtained from literature and used to construct compartmentalized models for nicotine and cotinine …
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Preclinical evaluation of dissolvable microarray patches for allergy treatment: key factors governing in vitro and in silico assessment
… first-pass metabolism and unpredictable pharmacokinetics. Skin delivery represents a promising alternative, with innovative platforms such as dissolvable microarray patches (MAP), offering the potential for targeted local and systemic drug effects. However, no dissolvable MAP have yet …