Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 179 for “"physiological role"”.
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Biochemistry and physiological role of otoferlin
Beim Menschen kann Taubheit durch Umwelteinflüsse, aber auch durch genetische Faktoren verursacht werden. Mutationen im Gen für otoferlin, die zu DFNB9, einer autosomal-rezessive nicht-syndromalen Schwerhörigkeit führen, sind eine genetische Ursache der Taubheit. Die Funktion von otoferlin ist noch …
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Exploring the Physiological Role of Vibrio fischeri PepN
… competed normally at 24 hours. To address the role of PepN in colonization initiation and establish additional phenotypes for the pepN mutant strain, stress response and other physiological assays were employed. Marked differences were found between pepN mutant and wildtype strain in response …
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The physiological role of P2X4 receptors in lysosome function
… The main aim of this study was to identify physiological regulators of lysosomal P2X4Rs and to examine their role in lysosome Ca2+ signalling and fusion. The first candidate I investigated was P2X7R, which is typically co-expressed with P2X4R in immune and epithelial cells, and which has …
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Understanding the physiological role of the small RNA RydC
This project aims to understand the physiological role of the small RNA (sRNA) RydC and the signals controlling RydC production. RydC was previously shown to stabilize cfa (cyclopropane fatty acid synthase) mRNA, resulting in higher levels of cyclopropane fatty acids in the cell membrane. Here, we …
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Understanding the physiological role of cofactor F 420 in mycobacterium
… a KO-mutant of F420 in M. bovis BCG to study the physiological significance of this cofactor in mycobacteria. Using nitric oxide sensitivity and hypoxia models, both immensely relevant in tuberculosis research, we discovered that the F420 KO-mutants were very highly susceptible to death by …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
The role of the neurotransmitter serotonin (5-HT) in the taste bud is not well understood. Serotonin was long thought to be the neurotransmitter of taste signals from taste receptor cells (TRCs) to the gustatory afferent nerves, but the surprising discovery that this transmission is actually …
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Physiological role of mixed nitrogen nutrition in enhancing productivity of maize
… can optimize productivity. However, the physiological processes that are beneficially altered by mixed N have not been elucidated. Therefore, studies were conducted to compare plant productivity traits under mixed N or predominantly NO$\sb3\sp-$ nutrition. Mixed N nutrition enhanced early …
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The physiological role and characterization of melanin produced by Shewanella algae BrY
<p>Shewanella algae BrY is a Gram negative, facultative anaerobe isolated from the Great Bay Estuary of New Hampshire. This member of the gamma Proteobacteria demonstrates extensive versatility in the variety of terminal electron acceptors it uses for anaerobic respiration. Since the natural …
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Physiological role and quantitative aspects of human Nonsense-mediated mRNA decay (NMD)
… Despite the progress in the understanding of the role and mechanism of this pathway, the physiological impact of NMD on humans is not yet fully uncovered. To explore the functions of NMD in humans, I combined RNAi against the essential NMD factor UPF1 with genome-wide microarray analysis. My …
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The sweet taste study - Physiological role of sweet taste in glucose metabolism
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… growth factor receptor (EGFR) plays a pivotal role in physiological cellular processes, but its aberrant activation is linked to cancer progression. Endocytosis is a critical regulator of EGFR activity. We have previously identified a novel endocytic route of the EGFR, non-clathrin endocytosis …
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The physiological role of the two isoforms of DNA topoisomerase II in human cells
Unique functions of DNA topoisomerase IIalpha and IIbeta have been suggested. A human cell line which carries a homozygeous mutation of the nuclear localization sequence of the topoisomerase IIalpha gene expresses the isoform outside the nucleus at the onset of mitosis. At mitosis topoisomerase …
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The effects of elevated mitochondrial hydrogen peroxide in S. cerevisiae : a physiological role for cytochrome c peroxidase
The role of cytochrome c peroxidase (CCP), found in yeasts and some bacteria, is not clear. However, it is believed to play a role in H 2 O 2 detoxification. To probe the physiological role of CCP, a yeast strain deficient in the gene encoding CCP (x ccp1 ) was engineered and characterized with …
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Physiological Role of the α<sub>2</sub>-Isoform of the Na, K-ATPase in the Regulation of Cardiovascular Function
… expression pattern suggesting a tissue-specific role for the α-subunits. The α<sub>2</sub>-isoform of the Na,K-ATPase (α<sub>2</sub>) is the minor isoform of the Na,K-ATPase expressed in the cardiovascular system but is thought play a critical role in the regulation of systolic blood pressure …
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The Life of Prion: an investigation into the physiological role of a prion-like protein in the nematode Caenorhabditis elegans
… has led to an enlightened appreciation of the role of such proteins throughout the biota of life. Prion-like proteins subvert the dogma of the one-to-one structure-function relationship traditionally held onto when considering the physiology of proteins. Instead, these proteins display …
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The physiological role of relaxin in the pregnant gilt: The effects of relaxin on the physical and biochemical properties of the cervix and on mammary development in ovariectomized hormone-treated pregnant gilts
The purpose of this research was to determine the physiological roles of relaxin in pregnant gilts by ovariectomizing gilts during the last third of gestation followed by hormone replacement therapy. Nara and coworkers demonstrated that in pigs ovariectomized in late pregnancy a prolonged delivery …
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Identification, Characterization and Mechanism of the Estrogen Regulation of the Gene Encoding the Sodium /Hydrogen Exchanger -Regulatory Factor (nhe-Rf)
… studies were designed to help define the physiological role of estrogen-induction of the NHE-RF gene using two model systems. Immunocytochemistry was used to visualize NHE-RF in MCF-7 cells. Secondly, we created adenovirus that express the wild type or anti-sense NHE-RF RNA. By infecting …
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