Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"physiological pH"”.
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Development of an antirheumatic drug
… were synthesised and characterised using the physical techniques, NMR, mass- and infrared spectrometry. The stability constants of the complexes of Mg, Ca, Zn and several first transition metal-ions with the ligands were determined potentiometrically. The solution conformation of the CuII …
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The use of aminoglycoside antibiotic therapy in neutropaenic patients with haematological disease
… A review of the literature on aminoglycoside Pharmacology and clinical use is essential to determine therapeutic guidelines for this population. Aminoglycosides are amino sugars in glycosidic linkage and are polycations at physiological PH. The antibiotic effect is mediated through inhibition …
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Characterization of the Genes Involved in Biosynthesis and Transport of Schizokinen, a Siderophore Produced by <em>Rhizobium leguminosarum</em> IARI 917.
… as a cofactor for many enzymes; however, at physiological pH and aerobic conditions iron forms insoluble ferric oxyhydroxide polymers. Siderophores are low molecular weight compounds that scavenge ferric ions, bind with high affinity, and transport it into the cell via multicomponent …
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Immunological synapse arrays : patterned protein surfaces that modulate immunological synapse structure formation in T cells
… (IS). It remains unresolved whether the unique physical structure of the synapse itself impacts the functional response of T cells, independent of the quantity and quality of ligands encountered by the T cell. As a first step toward addressing this question, we fabricated multicomponent protein …
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Functional polymers for biomedical application : synthesis and applications
Aromatic and aliphatic diacid chlorides were used to condense naturally occurring diamino acids and their esterified derivatives. It was anticipated the resulting functional polyamides would biodegrade to physiologically acceptable compounds and show pH dependant solubility could be used for …
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Design of novel copper(II) based anti-inflammatory drugs for the elevation associated with Rheumatoid Arthritis
… that CU(I1) formed far more stable complexes at physiological pH with PCUL than the in vivo competitor Zn(I1). In this study the IR spectroscopic analysis was used to determine the Cu(I1)-PCUL complexation sequence. The IR spectra show that the central amines are coordinated to the metal ion …
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Direct conversion of chemical energy to mechanical work using a phosphate charged protein
… mechanical work under modest conditions, i.e., physiological pH and ambient temperature and pressure. One of the most interesting systems is muscle modeled as the "sliding filament" system. The sliding filament system is a combination of a thin actin filament and a thick myosin filament that …
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The role of potential antioxidant in medicinal drug-induced oxidative stress
… However, the negative charge of NAC at physiological pH limits its bioavailability. N-acetylcysteineamide (NACA) is neutral in charge and is believed to have higher lipophilicity than NAC. Experiments were designed to determine the potential protective ability of NACA against different …
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Great Expectations: Phosph(On)Ate Prodrugs In Drug Design—Opportunities and Limitations
<p>Phosphate and phosphonates are chemical moieties with historical precedence in anticancer and antiviral nucleotide analogues. Synchronous to modern efforts identifying novel therapeutic targets in cancer, such chemical moieties are being investigated in the design of novel inhibitors with …
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Liposome drug delivery systems for anticancer agents
<p>Development of liposome formulation of an amphiphilic anticancer peptide using the ANTS/DPX leakage assay. The effects of lipid composition on the liposomes' resistance to an amphiphilic cyclic peptide c[KS.S.S.KWL W] were studied by the ANTS/DPX leakage assay. One or more unsaturated acyl …
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Multiscale Simulations of Phosphatidylinositol Bisphosphate: Understanding Its Biological Role Through Physical Chemistry
… are zwitterionic or have a charge of -1 at physiological pH, but some lipids such as phosphatidylinositol bisphosphate (PtdInsP2) bear a net charge of -4. The ability of these highly charged lipids to interact with monovalent and divalent cations affects their spatial organization and …
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Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles
… rendered PGAAs buffering capacity around physiological pH. To test the feasibility of the mechanism for PGAAs, new no buffering capacity guanidine or methylguanidine containing poly(glycoamidoguanidine)s (PGAGs) were synthesized. PGAGs formed stable polyplexes with pDNA from N/P (# …
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The activity of pH membrane disruptive pseudopeptides and their subcellular fate in mammalian cells cultured in-vitro
… In nature, disruption of this membrane by amphiphilic peptides plays a central role in the pathogenesis by bacterial and toxin infections. These amphiphilic peptides contain both hydrophobic and weakly charged hydrophilic amino acid residues and upon activation they become integrated into the …
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Computational Studies on Nucleic Acid-Ion Interactions in Droplets and Bulk Solution
… of cancer. Nucleic acids are polyions under physiological pH of 7.4. Thus, DNA always associates with cations in the living cell. These cations are essential for maintaining DNA functions and structural stability. Experimental techniques showed that alkali metal cations are either diffused in …
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Haem and xenosiderophore mediated iron acquisition by sinorhizobium meliloti and pseudomonas aeruginosa
… due to the formation of insoluble hydroxides at physiological pH. To surmount these obstacles bacteria have evolved several mechanisms of iron acquisition. Sinorhizobium meliloti 2011, the endosymbiont of Medicago sativa, is capable of utilising several xenosiderophores and the haem compounds …
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Synthesis and characterization of phosphorous containing macromolecular polyether compounds
… is used in positron emission tomography. Neutral crown ethers and cryptands have been studied as carrier ligands for Rb<sup>+</sup> but exhibit low ion carrying capacity and high toxicity. The present study involved investigating a lariat ether containing an ionizable phosphoryl …
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Carnosine metabolism and function in the thoroughbred horse
… would produce a rapid decline in intra-cellular pH with a concomitant impairment of the contractile process. Carnosine (ß-alanyl-L-histidine, pK<sup>a</sup> 6.83) occurs at high concentration in equine muscle where it functions as an effective H<sup>+</sup> ion buffer at physiological pH. …
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Direct detection of homocysteine and syntheses of lanthanide complexes as biosensors
… determination of specific saccharides at physiologically relevant pH. Inspired by calcium-dependent recognition of saccharides by C-type lectins, a water-soluble salophene-lanthanum complex was synthesized. It can be used in the detection of neutral sugars at physiological pH. Anionic …
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Structural and Functional Characterization of GAPR-1, a Mammalian Plant Pathogenesis-related Protein in Lipid-enriched Microdomains of the Golgi Complex
… of 9.4, suggesting that GAPR-1 is a highly hydrophilic protein (Eberle, H. B. et al. 2002). In this thesis, this structural information, was used to i) study the interaction of GAPR-1 with membranes, ii) to obtain structural information on the protein, and iii) to identify proteins that interact …
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Synthesis and Characterization of Polymeric Materials as Sequestrants for Biological Applications
… (PMA) resins to electrostatically bind Dox at physiological pH. Comparative capture studies with uncharged PMA at low-pH conditions confirmed an 18-fold increase in Dox capture efficacy due to ionic interactions. Crosslink density and polymer flexibility also played pivotal roles, with more …
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