Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"physiological models"”.
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An IIOP architecture for Web-enabled physiological models
… information architecture to serve complex physiological information models and a means of delivering these models in a manner that allows interactive and distributed use. By redesign of existing models for distributed use, the HOP architecture provides general access across the Internet; …
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Extracting clinically-actionable information from wearable physiological monitors
… so as to help make clinical decisions. Wearable physiological sensors are developing rapidly, and pose a possible part of the solution to the demands of an aging population and rising health care costs. It is important that the data produced by such sensors be processed into information that is …
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Pacing strategy optimization for time trial cyclists with physiological constraints
… for time-trial cyclists by integrating physiological constraints with course-specific environmental factors. Two complementary methods are developed: one directly optimizes velocity profiles using total energy expenditure as a proxy for current energy, while the other optimizes power …
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Neuropsychological and psychophysiological correlates of anger expression styles
… anger expression style on cerebrally lateralized physiological responses to a neuropsychological stressor and a painful stimulus. Specifically, this research examined changes in systole and grip strength in response to a verbal fluency task, a figural fluency task and exposure to a cold pressor. …
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The design and numerical analysis of a microfluidicssystem for osteogenic differentiation of mesenchymal stemcells.
… tissue/organ in order to built more accurate physiological models. Allowing forcomplete control of key parameters such as mass flow, temperature, pH levels mechanicalstresses and more in a tightly controlled and defined three dimensional physio-chemicalenvironment.This thesis investigates …
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Development of Active Artificial Hair Cell Sensors
… behavior as the living cochlea. Two sets of physiological models are also examined: one set based on outer hair cell somatic motility and the other set inspired by active hair bundle motility. Compared to passive AHCs, simulation and experimental results for active AHCs show an amplified …
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Psychological Monitoring: Detecting Real-Time Emotional Changes
… levels comparable to those of traditional physiological models. Additionally, these emotional dimensions can be used to produce reasonable, discrete emotion probabilities based solely on theory (without requiring training data). These findings support a new model of emotion based on …
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Design of low complexity fault tolerance for life critical situation awareness systems
… and checking expected responses based on patho-physiological models. The proposed protocol organizes the medical information concisely and comprehensively to help medical staff validate treatments.The proposed protocol dynamically adapts to the patient conditions and side effects of treatments. …
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Development and analysis of a simple grey-box model of central sleep apnea
… physiology that brings together many existing physiological models. We perform a sensitivity analysis, concluding that signals of interest in PNEUMA are insensitive to changes in all but approximately twenty parameters. This justifies our goal of developing a small, simple model that captures …
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Mitochondrial Structure-Function in health and disease
… completely understood. We used a combination of physiological models, mitochondrial imaging, and biomimetic membrane studies to test the hypothesis that elamipretide and RYKF-cardiolipin interactions improved mitochondrial structure-function. Post-ischemic treatment with elamipretide sustained …
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Modulation of Transcription Factor Chromatin Association and Gene Transcription Program in Embryonic Stem Cell and Triple Negative Breast Cancer by Poly (ADP-Ribose) Polymerase 1
… PARP-1-Sox2 interplay is conserved in different physiological models. Interestingly, inhibiting PARylation activity causes gain of Sox2 binding to a set of genomic locations in TNBC cells, indicating that PARylation activity plays an antagonizing role in PARP-1-regulated Sox2 chromatin …
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ADAP1 Promotes Latent HIV-1 Reactivation by Tuning the KRAS-ERK-AP-1 Signaling-Transcriptional Axis
… human CD4+ T cell signaling programs. Using physiological models, I characterize ADAP1 expression is low in naïve and memory CD4+ T cells, but largely induced upon immune stimulation where it interacts with the immune signalosome. Using complementary biochemical and cellular assays, I …
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The Influence of Human Umbilical Vein Endothelial Cells in the Formation of Glioblastoma Spheroids in Three-Dimensional Microwells
… (2D) cell cultures have been used as physiological models for understanding the cellular and molecular behavior of the GBM tumors. They are also highly desirable for virus studies. However they may not provide threedimensional (3D) characteristics of the tumors. Therefore, there is an …
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A human spatial-chromatic vision model for evaluating electronic displays
… analysis. Rather, it is based on more veridical models of the human visual system (HVS), including multi-channel models of spatial vision, the zone theory of color vision, physiological models of retinal processes, and models of the optics of the eye. A display evaluation system consisting of the …
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The effects of tonic muscle pain on the sympathetic and somatic motor systems in humans
… the formulation of a multitude of theories and physiological models to postulate these mechanisms in humans. The vicious cycle theory – a popularised but unsupported theory in humans – suggests that muscle metabolites produced by static muscle contractions stimulate group III and IV muscle …
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Incorporating microclimate into habitat suitability analysis for plethodonitd salamanders
… Furthermore, commonly used species distribution models may not account for mechanistic aspects, like physiology, that are relevant to the biology and performance of a species. This dissertation integrates aspects from three main components of a species’ niche (the habitat, trait, and performance …
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Targeting anti-androgen resistance in prostate cancer using preclinical models with physiological nutrient levels
… therapies. This could be partially due to non-physiological nutrient levels in traditional cell culture media such as RPMI, which could mask therapeutic effects or resistance mechanisms. The culture media Plasmax, formulated with nutrients at physiological levels, was able to maintain the …
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Modelling cardiopulmonary interactions. Towards anatomically detailed and physiologically accurate cardiorespiratory models
… a growing interest in understanding the complex physiological mechanisms that regulate the cardiovascular and respiratory systems and their interactions, due to the increasing healthcare burden related to cardiorespiratory diseases. To this end, physiologically accurate mathematical and …
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Astrocytic Sonic Hedgehog signalling in development and disease
… mechanism, demonstrating significant efficacy in models of neonatal stroke (Nguyen et al., 2021), hypoxic injury (Heine et al., 2011), and neurodegenerative disease (Li et al., 2020). In these settings, Shh signalling has been shown to mitigate neuronal damage, enhance cell survival, and support …