Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"physiological model"”.
-
Development and characterization of an in vitro culture system as a physiological model for chronic Hepatitis B infection
Human Hepatitis B virus (HBV) is the prototype member of the family Hepadnaviridae that consists of enveloped, partially double stranded DNA viruses that specifically target hepatocytes for viral replication. Although a vaccine has been available for more than 20 years chronic HBV infection …
-
Experimental evaluation of subjective ratings of drowsiness and development of drowsiness definitions
… many different indicators, such as different physiological measures. This thesis consists of two separate, but related, experiments to determine an optimal method of determining whether or not an individual is drowsy via physiological and observed measures. The first part of the experiment …
-
An analog VLSI vocal tract
Increasingly, circuit models of biology are being used to improve performance in engineering systems. For example, silicon-cochlea-like models have led to improved speech recognition in noise and low-power cochlear-implant processors for the deaf. A promising approach to improve the naturalness of …
-
Aristotle’s On Memory and Recollection: Concepts, Sources, and Innovations of Aristotle’s Account of Mnemonic Capacities and Activities
… it gave Aristotle some ideas (e.g. the wax block model) he assumed as his physiological model of memory. However, some of these intuitions were already present in previous reflections, both in poetry and in the political debate. What can be recognized from the comparison between those sources is …
-
Development of an ‘artificial human’ for clothing research
… has the primary im-pact on thermal comfort, physiological response of the human body and environmental strain. On the other hand, the clothing microenvironment is affected by physiological reactions (sweating, temperature distribution, body movement). Nowadays, thermal sweating manikins used …
-
Homeostasis and volume regulation in the Plasmodium falciparum infected red blood cell
… by comparison with predictions from a detailed physiological model of the homeostasis and volume regulation of infected cells, providing broad support to the view that excess haemoglobin consumptions by the parasite was necessary for the integrity of infected cells (the colloidosmotic …
-
Approximate credibility intervals on electromyographic decomposition algorithms within a Bayesian framework
… to extend ICA both to incorporate prior physiological information, thus making it in effect a semi-blind source separation (SBSS) algorithm, and to quantify the uncertainties around the values of the sources as estimated by ICA. To this end, this thesis also presents a way to put a prior …
-
The degradation of gel-spun poly(beta-hydroxybutyrate) fibrous matrix
… procedure was used in an accelerated degradation model which accurately monitored the degradation of the undegraded and degraded fractions of a fibrous matrix and the degradation of its PHB component. The in vitro degradation mechanism was also monitored using phase contrast and scanning electron …
-
A novel device for interrogation of neuron connectivity in acute brain slices
… in different functional regions, can provide a physiological model of appropriate neuronal behaviour. This could potentially be used to identify neuronal behaviours indicative of pathological states such as Alzheimer's disease.;Advancements in imaging technologies, such as calcium imaging and …
-
Incorporating microclimate into habitat suitability analysis for plethodonitd salamanders
… planning. However, current approaches to modeling suitable habitat typically rely on climate data that do not account for important buffering effects of vegetation on near-surface microclimates and are produced at spatiotemporal scales irrelevant to a variety of organisms that thrive in …
-
Defining Epithelial Cell Fate Dynamics of the Oesophagus during Postnatal Development and Homeostasis
… Postnatal development provides an ideal physiological model of rapid but restricted tissue growth, in which cells switch from a state of expansion to the steady state of homeostasis. In this project, I investigated the cellular and molecular mechanisms that govern this transition in the …
-
Dendrochronological investigations of living and relict yew trees from eastern England
… from the same region. I then develop an eco-physiological model based on dual isotopic signal from stable oxygen and carbon isotopes (δ18O and δ13C) to reconstruct hydroclimatic changes on interannual to centennial timescales between 5220 and 4150 years ago. Juxtaposing the pre-industrial and …
-
Parametric heart modelling and in silico closed-loop validation of implantable devices
… in silico closed-loop system, incorporating a physiological environment model, is likely to reveal safety risks at the early stage of development before animal testing and clinical trials. However, the closed-loop validation of implantable cardiac device is yet to be thoroughly investigated. …
-
The Role of Resveratrol and Sirtuin1 in Skeletal Muscle Under a Nutrient Stress
… reductions in cancer incidence. Despite these physiological improvements, the regulation of skeletal muscle mass is extremely sensitive to alterations in nutrients [reviewed in (Sharples et al., 2015)] and as such has been reported to reduce regenerative potential and increase atrophy in …
-
Hydrogen peroxide from photosynthesis: Theory and experiments linking elevated atmospheric CO2 with C3 plant chemical defense
… output of reactive oxygen under variable CO2. To model this effect, the metabolic pathway responsible for generating hydrogen peroxide in plant chloroplasts was incorporated into the e-Photosynthesis in silico model of photosynthesis. At the same time, soybean grown at the soyFACE (Free Air CO2 …
-
Astrocytic Sonic Hedgehog signalling in development and disease
… mechanism, demonstrating significant efficacy in models of neonatal stroke (Nguyen et al., 2021), hypoxic injury (Heine et al., 2011), and neurodegenerative disease (Li et al., 2020). In these settings, Shh signalling has been shown to mitigate neuronal damage, enhance cell survival, and support …
-
Electroencephalography of premature infants
… We used cohort 1 to develop a multimodal model for the prediction of neurodevelopmental outcome. This model incorporated simultaneous multi-channel electroencephalography (EEG), peripheral oxygen saturation (SpO2), and heart rate (HR) recordings. One-hour epochs of EEG, HR and SpO2 were …