Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"physical stability"”.
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Evaluation and enhancement of physical stability of amorphous solid dispersions
… primary reason for this is a combination of the stability and scale up issues associated with this approach, which has been reported by several authors.[13-15] Hot-melt extrusion currently stands as the most promising approach for solving the scale up issues associated with amorphous solid …
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Investigation of glucose hydrate formation and loss: Parameters, mechanisms, and physical stability
… it is important to determine the chemical and physical stability of α-AG and GM during storage. This research investigated hydrate formation in α-AG and hydrate loss in GM. Under dynamic conditions, hydrate formation occurs before deliquescence in both α-AG and GM. Therefore, this research …
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Investigation of the factors contributing to the physical stability of biological therapeutics
… The mechanisms behind such losses in physical stability, which is itself sensitive to a wide range of factors, can result in batches of the same therapeutic displaying different aggregation behaviour. Glucagon-like peptide 1 (GLP-1) is 31-residue peptide that, along with its analogues, …
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Investigating the Structure and Physical Stability of Glp1-Like Peptides Using Mass Spectrometry
… shelf-life. In addition to chemical degradation, physical aggregation of peptides into oligomers and fibrils can compromise the safety, efficacy and bioavailability of peptide therapeutics. It is imperative that we understand these processes, not only to mitigate for them, but so we can develop a …
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Applicability of Using Physical Stability Data and Advanced Visualization Methods in Protein Comparability Studies
… ability of using multiple protein conformational stability studies (combined with novel data visualization approaches) as surrogates for evaluating and comparing different proteins's higher-order structure are explored in the context of comparability. Empirical phase diagrams (EPDs) and radar …
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Studies of the Physical Stability of GLP-1 & Chemically Modified Forms of GLP-1
… problems, such as short lifetimes and low stability. Lipidation of peptides is widely established as a means of increasing stability in vivo. However, relatively little is known about the effect of lipidation on peptide self-assembly and other aggregation phenomena in vitro. The aim of this …
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Studies on the physical stability of a C-terminally amidated variant of GLP-1
… concentrations. In addition, the long-term physical stability of therapeutic peptides is essential for storage and use of these drugs, and also influences their half-lives in vivo. Therefore, aggregation of peptide-based therapeutics remains a great challenge for the pharmaceutical industry. …
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The effect of additives on the molecular mobility, physical stability and dissolution of amorphous solid dispersions
… testing method for predicting the solid-state physical stability of drugs in amorphous solid dispersions (ASD), (ii) gain a mechanistic understanding of the stabilization in the amorphous state brought about by small molecule excipients, and (iii) investigate the relationship between …
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Developing a rapid method for assessing the physical stability of streams in Minnesota's Agassiz beach ridges
<p> This thesis assessed the physical characteristics and stability of selected western Minnesota streams that cross the eastern beach ridges of glacial Lake Agassiz. Stream and river channels in this area host unusually diverse aquatic habitat and biodiversity, but incompatible land use along …
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Development of Methods to Predict and Enhance the Physical Stability of Hot Melt Extruded Solid Dispersions
… because of their meta-stable nature, the physical stability of amorphous solid dispersions has been considered to be the main obstacle for their formulation development and commercialisation by the pharmaceutical industry. The aim of this project was to understand, predict and enhance the …
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Chemical and physical stability of spray-dried and glass encapsulated spray-dried flavors stored below their glass transition temperatures
… for spray-dried (SD) flavors to further enhance stability and extend shelf life. The objectives of this research were to: 1) compare and contrast the chemical and physical stability of SD and two MET flavors, 2) compare the chemical and physical stability at all storage temperatures (Ts) and …
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Further exploring the pharmaceutical applications of novel microwave-induced in situ amorphization
… solubilizing technology to tackle the persistent physical stability and problematic downstream processing issues of amorphous solid dispersions (ASDs). However, the current available research in this field is limited and some issues identified in the existing studies require further exploration. …
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Production of stable bcs class ii drug suspensions by melt emulsification and subsequent incorporation into polymer strip films
… polymers and surface-active agents) on particle stability is investigated. Moreover, different agitation techniques during cooling are studied for their impact on the physical stability and recrystallization of molten drug particles. The use of both nonionic surfactant Pluronic F68 and …
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Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer
… was optimized to maximize drug loading and physical stability. Cholesterol and saturated lipid content showed a negative influence on paclitaxel loading. Short-term stability studies showed that optimum drug-lipid ratio is necessary for adequate physical stability. Biodistribution studies in …
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The development of PVP-based solid dispersions using hot melt extrusion for the preparation of immediate release formulations
… commercially limited due to the concerns of its physical instability, unpredictability and inconsistency formulation performance. This is attributed to the lack of fundamental understanding on the processing method, physicochemical properties of the obtained solid dispersion. Therefore, better …
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Assessment of nanocomposites vs. amorphous solid dispersions for dissolution enhancement of bcs class ii drugs
… general stabilization strategy for ensuring the physical stability of five different wet-milled drug nanosuspensions via combined use of a polymer (HPC: hydroxypropyl cellulose)-anionic surfactant (SDS: sodium dodecyl sulfate). A microhydrodynamic model is used for enhanced process understanding …
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Physical analysis of solid solution formulations
… rate of drugs with low aqueous solubility. The physical stability of the amorphous solid dispersion is the main challenge for their formulation development and commercialisation by pharmaceutical industry. The aims of the project were to prepare amorphous solid solution of a poorly aqueous …
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Polymer drug dispersions: understanding structure and dynamics
Poor physical stability is a limiting factor in the pharmaceutical development of APIs. Amorphous drugs are attractive due to increased dissolution; however can unpredictably revert to the thermodynamically stable crystalline form. Accurate prediction of molecular level physical stability would be …
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Novel derivatives of sporopollenin for potential applications in solid phase organic synthesis and drug delivery
… is exceptionally resistant to chemical and physical attack and is perhaps one of the most chemically resistant, naturally occurring organic materials known. Its stability to chemical and physical stress is illustrated by its survival in ancient sedimentary rock of around 3.7 billion years …
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Lipid Bilayer Formation in Aqueous Solutions of Ionic Liquids
… the ionic liquids have negligible effects on the physical stability and electrical properties of the bilayer. It is also shown that the magnitude of the conductance levels of Alamethicin peptide are altered by some ionic liquids.
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