Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"phototoxicity"”.
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Mechanistic, Biochemical, and Theoretical Studies of Phototoxicity and Photobluing
… classes that add toxicity above and beyond the phototoxicity. The photooxidation of prenyl phenol leads to primary products dihydrobenzofuran, hydrogen peroxide, and ‘ene’ allylic hydroperoxides. On extended photolysis, secondary products were detected by 1D and 2D NMR techniques, including …
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Selenium-induced Enhancement of Hematoporphyrin Derivative Phototoxicity in Murine Bladder Tumor Cells
<p>The phototoxicity of hematoporphyrin derivative (Hpd) to murine bladder tumor (MBT-2) cells was studied in vitro. It was observed that selenium in the form of sodium selenite enhanced Hpd-sensitized photodamage in MBT-2 cells under conditions where the selenite alone was non-toxic. Sodium …
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A study of the phototoxicity induced in rats by pyropheophorbide a and related derivatives of chlorophyll
Thesis (M.S.)--Michigan State University. Dept. of Food Science, 1969
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Phototoxic target lipid model for predicting the toxicity of polycyclic aromatic hydrocarbons and petroleum to aquatic life
… is to develop a model to predict the phototoxicity of petroleum and petroleum components to aquatic organisms. Petroleum contains polycyclic aromatic hydrocarbons (PAHs), alkylated PAHs and heterocyclic PAHs some of which absorb light in the ultraviolet light (UV) and visible (VIS) …
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Quantified phenotype analysis in a cell model for Autosomal Dominant Retinitis Pigmentosa
… and accelerated cellular death, we assessed phototoxicity caused by blue light illumination. We quantified motility and division rates in PC3 and GMK mammalian cell cultures, respectively. A surprisingly low phototoxicity threshold of 13.9 J/cm2 was determined for imaging unlabelled GMK cells …
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Targeted nanoparticle platforms for selective photodynamic therapy of cancer
… to the non-conjugated particles. Similarly, the phototoxicity of the HT-29 cells incubated with the jacalin conjugates was dramatically improved following irradiation at 633 nm, as compared to treatment using the non-conjugated particles. The PDT efficacy of the lectin-photosensitising …
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Synthesis, Characterization, and Evaluation of Novel BODIPY Dyes With Theranostic Applications
… of BODIPY were found to influence the phototoxicity of diiodo-BODIPYs, with some possessing phototoxicity while others were non-toxic. The photophysical properties of these compounds were also explored computationally in collaboration with Dr. Petia Bobadova-Parvanova of Rockhurst …
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Quantitative analysis of axon elongation : a novel application of stochastic modeling techniques to long-term, high-resolution time-lapse microscopy of cortical axons
… imaged once every few minutes for up to weeks if phototoxicity is minimized. Looking at the data, the trajectories of axon growth cones seem to alternate between long, straight segments and sudden turns. I first rigorously test the idea that the straight segments are generated from a biased random …
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A Role For Reactive Oxygen Species In Photodynamic Therapy
… levels from 20% to 1% did not alter the phototoxicity of NPe6. WST11 phototoxicity was reduced in the 1% oxygen. </p> <p>In a cell-free system, the initial rate of formation of singlet oxygen from NPe6 was independent of the oxygen content. For both NPe6 and WST11, formation of hydroxyl …
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Methods for optical microscopy beyond conventional limits
… microscopy while reducing photodamage and phototoxicity. Measurements of the structures of fluorescent shells with 10 nm precision, derived from conventional wide-field micrographs and a quantitative image analysis routine, are presented and used to study bacterial spore coats. A design for …
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DISSECTING THE ROLE OF REACTIVE OXYGEN SPECIES IN EARLY MAMMALIAN EMBRYOGENESIS
… after 20 minutes imaging, suggesting that phototoxicity may contribute to this rise during the image acquisition procedure. Nevertheless, both oocytes and zygotes exposed to a prooxidant (tBOOH) exhibited higher H2O2 levels than the control group, validating the sensor's capacity to …
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Singlet oxygen generating luminescent lanthanide complexes with naphthalimide-based and oligothiophene-based sensitizers
… their emission in vitro, determining their phototoxicity and dark toxicity, and the resulting cell death mechanism. With these combined data, the usefulness of these compounds as potential therapeutics with dual activity can be assessed and optimized. The complex with the highest …
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Two-Color Fluorescent Analysis of Connexin 36 Turnover and Trafficking – Relationship to Functional Plasticity
… was impaired when laser power was focused and phototoxicity may be responsible. To better understand mechanisms of turnover we studied the role of cytoskeletal elements, actin filaments in particular, in Cx36 vesicle trafficking and GJ mobility. Phalloidin labeling showed that thick actin …
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Effects of Nutrients and Minerals on Growth and Detoxification in Phytophagous Insects
… a generalist herbivore, vitamin A ameliorates phototoxicity caused by ingesting citral, an insecticidal monoterpene. As an antioxidant, vitamin A may protect against UV-mediated citral damage by scavenging free radicals or quenching singlet oxygen. Vitamin C, a water-soluble antioxidant, had a …
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Investigating non-canonical vertebral development in the zebrafish model system
… to target the chordoblasts for KillerRed-induced phototoxicity. I demonstrated that intact chordoblasts are necessary for chordacentrum formation, but that vertebral arches are unaffected. Fused perichordal centra are still able to form, but the underlying sheath has a very different structure. …
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Synthesis of Fluorescent Molecules and their Applications as Viscosity Sensors, Metal Ion Indicators, and Near-Infrared Probes
… for near-IR emission and reduce photodamage and phototoxicity that is characteristic of common fluorphores that are excited by UV or visible light. A 30-fold enhancement of fluorescence intensity of dU-BZ was achieved in a viscous environment. Values of fluorescence quantum yields in 99% …
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Mathematical Imaging Tools in Cancer Research - From Mitosis Analysis to Sparse Regularisation
… on phase contrast microscopy, hence avoiding phototoxicity and influence on cell behaviour. As a drawback, the common halo- and shade-off effect impede image analysis. We present a novel workflow uniting both automated mitotic cell detection with the Hough transform and subsequent cell …
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Biochemical Investigations of Macular Degeneration: The Significance of Protein Oxidation including Novel Methods for Its Study
… in chapter 2. The accumulation, composition and phototoxicity of MLF were analyzed to assess MLF's origin and possible contribution to AMD. These results are reported in chapter 3. Because protein oxidation is possibly a common posttranslational modification to proteins which accumulate in …
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Photoimmunotheranostic targeting of CSPG4-positive melanoma cells using SNAP-tag technology
… IRDye 700DX (IR700) has produced no phototoxicity as of yet. In light of the convincing binding analysis, it is concluded that inefficient solubilization of the lyophilized product resulted in inadequate conjugation of BG-IR700 with SNAP-tag. Nonetheless, steps have been planned to …
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Development of the multi-scale dynamic modeling techniques for multi-modal brain recordings
… STED-beam power, the resulting photodamage and phototoxicity are major issues for real-world applications of STED microscopy. In Chapter 4, I demonstrated that, with 50% less STED-beam power, the STED image resolution can be improved up to 1.45-fold using the separation of photons by a lifetime …
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