Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"photorelease"”.
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Peptide/Protein Stapling and Unstapling: Introduction and Photorelease of Isobutylene Graft
Intramolecular side-chain-to-side-chain crosslinking, also termed “stapling”, is an important technology in the development of bioactive peptide-based therapeutics. Among all of the tools, S-alkylation is one of the most flexible approaches, as a wide range of bis-thiol-reactive linkers are …
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Design, synthesis and characterization of photocage molecules for light-activated release: Applications in polymer chemistry and phototherapeutics
… chemical yields and good quantum yield of photorelease. But the releasing efficiency of the photocages with an array of leaving groups were also found to be dependent on the nature of the leaving group, any of the linker used and the photocages. The plot of pKa against the quantum yield of …
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOACTIVE MOLECULES LINKED TO PHOTOREMOVABLE PROTECTING GROUPS FOR SPATIO-TEMPORAL CONTROL OF THEIR ACTIVITY THROUGH PHOTOACTIVATION
… due to the presence of esterases. Moreover, the photorelease of tertiary amines has been only rarely reported for such PPGs. A notable exception is represented by derivatives of 8-cyano-7-hydroxyquinolin-2-ylmethyl (8CyHQ), which have been specifically developed and optimized for the release of …
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Second Generation Photoactivated Insulins
… a transcutaneous irradiation. Since the insulin photorelease is a photochemical reaction, the amount released can be tightly controlled by varying the duration of irradiation. PAD is beneficial for diabetics as it can deliver insulin in a continuously variable fashion and can be automated as an …
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Novel Photochemical Methodologies for Diversity Oriented Synthesis and Screening of Combinatorial Libraries
… of solution phase libraries based on the photorelease of externally sensitized photolabile tags. The encoding tags can be released into solution only when a binding event occurs between the ligand and the receptor, equipped with an electron transfer sensitizer. The released tags are …
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Activatable photoacoustic contrast agents for sensing and delivering nitric oxide, and development of small molecule photoacoustic platforms with improved properties for in vivo imaging
Molecular imaging is a rapidly expanding and highly interdisciplinary field which strives to visualize and (ideally) quantify chemical and biological processes in living systems. Fortunately, the accessibility of microscopy instrumentation, the commercial availability of a variety of fluorescent …